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All times are CEST (UTC + 2)
| Arsenal – Watford | 3:0 (end) | | | Bournemouth – Tottenham | 1:4 (end) |
| Espanyol – Real Sociedad | 2:1 (end) | | | Atlético – Celta Vigo | 3:0 (end) | | | Las Palmas – Villarreal | 0:2 (end) |
| Bilbao – Leganés | 2:0 (end) |
| Stuttgart – RB Leipzig | 0:0 (end) | | | Dortmund – Frankfurt | 3:2 (end) |
| Groningen – Zwolle | 2:0 (end) | | | Utrecht – Arnhem | 5:1 (end) | | | Ajax – Heerenveen | 4:1 (end) |
| Feyenoord – Alkmaar | 2:1 (end) |
| Anderlecht – Antwerp | 2:1 (end) | | | Genk – Gent | 1:2 (end) | | | Kortrijk – Charleroi | 2:0 (end) |
| Eupen – Mouscron | 4:0 (end) | | | Oostende – Standard | 2:3 (end) | | | Mechelen – Waasland-Beveren | 2:0 (end) |
| Lokeren – Waregem | 0:2 (end) | | | Sint-Truiden – Club Bruggy | 0:1 (end) |
| Portimonense – Guimarães | 2:1 (end) | | | Marítimo – Setúbal | 4:2 (end) | | | Belenenses – Tondela | 0:0 (end) |
| FC Ferreira – Porto | 1:0 (end) |
| Mattersburg – Salzburg | 2:2 (end) |
| Rostov – FC Zenit | 0:0 (end) | | | Grozny – CSKA Moskva | 0:3 (end) | | | Spartak – Chabarovsk | 1:0 (end) |
| Jablonec – Ostrava | 2:0 (end) | | | Slavia – Olomouc | 3:1 (end) | | | Plzeň – Liberec | 2:2 (end) |
| Žilina – Slovan Bratislava | 2:0 (end) |
Goals:
33. Boëtius, 73. N. Jörgensen – 90+2. Weghorst
Ball possession: 48 % : 52 %.
Shots on target: 4:4. Shots off target: 8:6. Corners: 2:8. Offsides: 3:1. Fouls: 16:17.
Referees:
Attendance:
Cards: 20. Toornstra (FEY), 61. van der Heijden (FEY) – 23. Jahanbakhsh (ALK), 25. Idrissi (ALK)
Penalty missed:
Ball possession: 48 % : 52 %.
Shots on target: 4:4. Shots off target: 8:6. Corners: 2:8. Offsides: 3:1. Fouls: 16:17.
Feyenoord Rotterdam:
Jones – Diks, van Beek, van der Heijden, Haps – El Ahmadi, Toornstra, Vilhena – S. Berghuis, N. Jörgensen, Boëtius.
Subs: Bijlow, Ten Hove – S. Amrabat, Basaçikoglu, Botteghin, Malacia, Nieuwkoop, Tapia, van Persie, Vente.
Coach:
AZ Alkmaar: Bizot – J. Svensson, Hatzidiakos (46. Vlaar), S. Wuytens, Ouwejan – Midstjö, Til (75. van Overeem), Koopmeiners – Jahanbakhsh, Weghorst, Idrissi (46. M. Seuntjens).
Subs: Coutinho – Bel Hassani, M. Seuntjens, van Overeem, van Rhijn, Vlaar, Wijndal.
Coach:
Subs: Bijlow, Ten Hove – S. Amrabat, Basaçikoglu, Botteghin, Malacia, Nieuwkoop, Tapia, van Persie, Vente.
Coach:
AZ Alkmaar: Bizot – J. Svensson, Hatzidiakos (46. Vlaar), S. Wuytens, Ouwejan – Midstjö, Til (75. van Overeem), Koopmeiners – Jahanbakhsh, Weghorst, Idrissi (46. M. Seuntjens).
Subs: Coutinho – Bel Hassani, M. Seuntjens, van Overeem, van Rhijn, Vlaar, Wijndal.
Coach:
Referees:
Attendance:
AZ Alkmaar substitution: Pantelis Hatzidiakos is replaced by Ron Vlaar.