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All times are CEST (UTC + 2)
| Tottenham – Huddersfield Town | 4:0 (end) | | | Southampton – Wolverhampton | 3:1 (end) | | | Man Utd. – West Ham | 2:1 (end) |
| Espanyol – Alavés | 2:1 (end) | | | Huesca – Barcelona | 0:0 (end) | | | Atlético – Celta Vigo | 2:0 (end) |
| Sevilla – Betis | 3:2 (end) |
| Bremen – Freiburg | 2:1 (end) | | | Hannover – Mönchengladbach | 0:1 (end) | | | RB Leipzig – Wolfsburg | 2:0 (end) |
| Stuttgart – Leverkusen | 0:1 (end) | | | Dortmund – Mohuč | 2:1 (end) |
| Alkmaar – Den Haag | 2:3 (end) | | | Ajax – Excelsior | 6:2 (end) | | | Feyenoord – Heracles | 2:1 (end) |
| Sittard – Venlo | 1:1 (end) |
| Beerschot – Eupen | 2:0 (end) | | | Waregem – Mouscron | 2:2 (end) | | | Kortrijk – St.Gilloise | 0:1 (end) |
| Sint-Truiden – Oostende | 1:0 (end) | | | Gent – Antwerp | 1:2 (end) |
| Santa Clara – Moreirense | 1:1 (end) | | | Portimonense – Porto | 0:3 (end) | | | Aves – Sporting | 1:3 (end) |
| Hartberg – Rheindorf Altach | 0:1 (end) | | | Wacker – Admira | 1:3 (end) | | | Rapid – Mattersburg | 2:1 (end) |
| Jenisej – Ufa | 0:0 (end) | | | Arsenal Tula – Ural | 0:0 (end) | | | CSKA Moskva – Orenburg | 2:3 (end) |
| Grozny – Lok. Moskva | 1:3 (end) |
| Slovácko – Příbram | 2:0 (end) | | | Opava – Olomouc | 2:1 (end) | | | Karviná – Zlín | 2:0 (end) |
| Plzeň – Ostrava | 2:1 (end) |
| Sereď – Dunajská Streda | 0:5 (end) | | | Ružomberok – Michalovce | 1:0 (end) | | | Trenčín – Zlaté Moravce | 1:0 (end) |
| Senica – Nitra | 4:1 (end) | | | Podbrezová – Trnava | 0:0 (end) |
| Rizespor – Göztepe | 1:0 (end) | | | Konyaspor – Sivasspor | 1:1 (end) | | | Beşiktaş – Başakşehir | 2:1 (end) |
final
Southampton FC
3:1
(2:1)
Wolverhampton Wanderers
Goals:
2. Redmond (Sims), 30. Redmond (Ings), 71. S. Long (Jošida) – 28. Boly (Moutinho)
Ball possession: 29 % : 71 %.
Shots on target: 6:2. Shots off target: 6:7. Corners: 4:9. Offsides: 0:2. Fouls: 11:6.
Referees: Jonathan Moss – Marc Perry, Constantine Hatzidakis
Attendance:
Cards: 67. Bertrand (SOT) – 40. Moutinho (WOS), 45+2. Jiménez (WOS), 75. Saïss (WOS)
Penalty missed:
Ball possession: 29 % : 71 %.
Shots on target: 6:2. Shots off target: 6:7. Corners: 4:9. Offsides: 0:2. Fouls: 11:6.
Southampton FC:
Gunn – Bednarek, Jošida, Vestergaard – Valery (84. J. Stephens), Ward-Prowse, P.-E. Höjbjerg (C), Bertrand – Sims (61. Romeu), Redmond – Ings (61. S. Long).
Subs: A. McCarthy – Armstrong, Ch. Austin, S. Long, Romeu, J. Stephens, Targett.
Coach:
Wolverhampton Wanderers: Patrício – Saïss, Coady (C), Boly – Doherty (60. Traoré), Dendoncker, Neves (70. Gibbs-White), Moutinho, J. Castro – Jiménez, Diogo Jota (87. Costa).
Subs: Ruddy – R. Bennett, Cavaleiro, Costa, Gibbs-White, Traoré, Vinagre.
Coach:
Subs: A. McCarthy – Armstrong, Ch. Austin, S. Long, Romeu, J. Stephens, Targett.
Coach:
Wolverhampton Wanderers: Patrício – Saïss, Coady (C), Boly – Doherty (60. Traoré), Dendoncker, Neves (70. Gibbs-White), Moutinho, J. Castro – Jiménez, Diogo Jota (87. Costa).
Subs: Ruddy – R. Bennett, Cavaleiro, Costa, Gibbs-White, Traoré, Vinagre.
Coach:
Referees: Jonathan Moss – Marc Perry, Constantine Hatzidakis
Attendance:
Southampton FC substitution: Joshua Sims is replaced by Oriol Romeu.