Penalty missed:

Heracles Almelo: B. Castro – Droste, D. Wuytens, Baas, Breukers – Niemeijer (88. Gladon), Pelupessy, Monteiro (88. Jakubiak) – Kuwas, Vermeij, Peterson (63. Darri).
Subs: Zeinstra, Brouwer – Jakubiak, Navrátil, Darri, Leemhuis, Gladon, van Ooijen, van de Berg.
Coach:

Sparta Rotterdam: Kortsmit – Holst, Breuer (78. Spierings), Fischer, Floranus – Sanusi (46. Brogno), Dougall, Duarte, Goodwin (83. Alhaft) – Proschwitz, Mühren.
Subs: Nienhuis, Craninx – Marfelt, Chabot, Veenhoven, Brogno, Alhaft, Verhaar, Spierings, van Moorsel, Ache, Harroui.
Coach:

Referees: Kamphuis – de Vries, Schaap

Attendance:

Penalty missed:

Ajax Amsterdam: Onana – Veltman, de Ligt, F. de Jong, Wöber (31. Dijks) – S. de Jong (72. Zeefuik), van de Beek, Ziyech – Neres (89. Eiting), Dolberg, Kluivert.
Subs: Lamprou – Eiting, Huntelaar, Dijks, Orejuela, Johnsen, Zeefuik, Mazraoui.
Coach:

SBV Excelsior: Zwarthoed – Fortes, Mattheij, De Wijs, Massop – Faik, Vermeulen (73. Messaoud), Koolwijk (90+2. Haspolat) – Caenepeel, van Duinen, Hadouir (73. El Azzouzi).
Subs: Havekotte, Kristinsson – Faes, Messaoud, El Azzouzi, Haspolat, Afaker.
Coach:

Referees: Janssen – van Dongen, van Zuilen

Attendance:

Penalty missed:

S. S. Lazio: Strakoša – Wallace, de Vrij, Patric – Basta, Murgia, Leiva, Lukaku – Milinković Savić – Anderson, Immobile (C)
Subs: Vargić, Guerrieri – Bastos, Parolo, Lulić, Caicedo, Radu, Felipe, Palombo, Neto, Jordão, Marušić
Coach:

AS Cittadella: Paleari – Pelagatti, Camigliano, Adorni, Pezzi – Settembrini, Bartolomei, Lora (C) – Chiaretti – Fasolo, Arrighini
Subs: Alfonso – Iori, Kouame, Litteri, Maniero, Pasa, Salvi, Scaglia, Schenetti, Varnier
Coach:

Referees:

Attendance: