Penalty missed:

Southampton FC: A. McCarthy – Bednarek, Vestergaard, Jošida (80. Ch. Austin) – Valery, Romeu (C), Lemina (87. M. Elyounoussi), Targett – Armstrong, Ings (62. S. Long), Redmond.
Subs: Gunn – Ramsay, Stephens, Ward-Prowse, M. Elyounoussi, S. Long, Ch. Austin.
Coach:

West Ham United: Fabiański – Antonio, Diop, Ogbonna, Cresswell (C) – Rice, Obiang – Diangana (55. Carroll), Snodgrass (90+2. Masuaku), Anderson – Lucas Pérez (78. Noble).
Subs: Adrián – Masuaku, Coventry, Noble, X. Silva, Carroll.
Coach:

Referees: Craig Pawson – Lee Betts, Ian Hussin

Attendance:

Penalty missed:

Sporting Lokeren: Verhulst – Deschacht (90+3. Symons), Diaby, Mareček, Filipović – Tičinović (74. A. Skúlason), Overmeire, Cevallos, Terki, de Ridder – Jovanović.
Subs: Mantel – Ben Harush, A. Skúlason, Benchaib, Michel, Saroka, Symons.
Coach:

Club Bruggy KV: Horvath – Poulain, Mitrović, Mechele, Mata (63. D. Cools) – Schrijvers, Nakamba (64. Vormer), Vanaken – Rits, Wesley, Dennis (88. Peres).
Subs: Letica – Peres, D. Cools, Denswil, Decarli, Vormer, Ngonge, Openda.
Coach:

Referees: Verboomen – Thijs, Wijns

Attendance:

Penalty missed:

RSC Anderlecht: Didillon – D. Appiah, Milić, Bornauw, Cobbaut – Kayembe, Kums – Najar (84. Saief), Morioka (83. Gerkens), Amuzu (90+1. Saelemaekers) – Dimata.
Subs: Boeckx – Doku, Gerkens, Lawrence, Saelemaekers, Saief, Santini, Trebel.
Coach:

Waasland-Beveren: Debaty – Caufriez, Moren, Vukotić – Schryvers (56. Badibanga), L. Verstraete, Bizimana (83. Jubitana), Massop – Ampomah, Lulič (63. Vellios), Forte.
Subs: Swolfs, Bleijenberg – Badibanga, Dierckx, Foulon, Gamboa, Jubitana, Keita, Vellios.
Coach:

Referees: Alen – Nijssen, Becquet

Attendance: