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All times are CEST (UTC + 2)
| Watford – Man Utd. | 1:2 (end) | | | West Brom – Arsenal | 2:1 (end) | | | Everton – Aston Villa | 4:0 (end) |
| Swansea – Bournemouth | 2:2 (end) | | | Newcastle – Leicester | 0:3 (end) | | | Chelsea – Norwich | 1:0 (end) |
| Southampton – Stoke | 0:1 (end) | | | Manchester City – Liverpool | 1:4 (end) |
| Real Sociedad – Sevilla | 2:0 (end) | | | Real – Barcelona | 0:4 (end) | | | Espanyol – Malaga | 2:0 (end) |
| Valencia – Las Palmas | 1:1 (end) | | | La Coruňa – Celta Vigo | 2:0 (end) |
| Mönchengladbach – Hannover | 2:1 (end) | | | Wolfsburg – Bremen | 6:0 (end) | | | Frankfurt – Leverkusen | 1:3 (end) |
| Kolín nad Rýnem – Mohuč | 0:0 (end) | | | Stuttgart – Augsburg | 0:4 (end) | | | Schalke – Bayern | 1:3 (end) |
| Alkmaar – Heerenveen | 3:1 (end) | | | Kerkrade – Zwolle | 0:5 (end) | | | Ajax – Cambuur | 5:1 (end) |
| Willem II – Eindhoven | 2:2 (end) | | | Graafschap – Groningen | 1:2 (end) |
| Club Bruggy – Waregem | 3:0 (end) | | | Leuven – Genk | 1:3 (end) | | | Waasland-Beveren – Sint-Truiden | 2:1 (end) |
| Austria – Admira | 1:1 (end) | | | Rheindorf Altach – Wolfsberger | 2:1 (end) | | | Ried – Grödig | 1:0 (end) |
| Mattersburg – Rapid | 1:6 (end) |
| Perm – Kazaň | 1:2 (end) | | | CSKA Moskva – Samara | 0:2 (end) | | | FC Zenit – Ural | 3:0 (end) |
| Lok. Moskva – Machačkala | 0:2 (end) |
| Olomouc – Dukla Praha | 0:0 (end) | | | Slovácko – Slavia | 0:2 (end) | | | Příbram – Zlín | 1:2 (end) |
| Bohemians 1905 – Ostrava | 3:1 (end) | | | Plzeň – Mladá Boleslav | 1:0 (end) |
| Ružomberok – Trenčín | 0:3 (end) | | | Senica – Žilina | 2:0 (end) | | | Myjava – Podbrezová | 2:1 (end) |
| Zlaté Moravce – Skalica | 3:1 (end) |
Goals:
54. Falkenburg, 63. Falkenburg – 12. Pereiro, 74. L. de Jong
Ball possession: 50 % : 50 %.
Shots on target: 5:5. Shots off target: 4:7. Corners: 3:3. Offsides: 0:2. Fouls: 10:9.
Referees:
Attendance:
Cards: 54. D. Pröpper (PSV), 83. Bruma (PSV), 85. Pereiro (PSV)
Penalty missed:
Ball possession: 50 % : 50 %.
Shots on target: 5:5. Shots off target: 4:7. Corners: 3:3. Offsides: 0:2. Fouls: 10:9.
Willem II Tilburg:
Lamprou – Joppen, D. Wuytens, Peters (C), van der Struijk – Ojo, van der Velden, S. Wuytens – Živković (90+1. de Sa), Falkenburg, Andersen.
Subs: Meul – Braber, de Sa, Heerkens, Koppers, Ligeon, Nemec.
Coach:
PSV Eindhoven: Zoet – Arias, Bruma, Isimat-Mirin, Brenet – Guardado, Hendrix (66. Maher), D. Pröpper – Pereiro, L. de Jong (C), Locadia (66. L. Narsingh).
Subs: Pasveer – Bergwijn, Maher, H. Moreno, L. Narsingh, S. Poulsen, Schaars.
Coach:
Subs: Meul – Braber, de Sa, Heerkens, Koppers, Ligeon, Nemec.
Coach:
PSV Eindhoven: Zoet – Arias, Bruma, Isimat-Mirin, Brenet – Guardado, Hendrix (66. Maher), D. Pröpper – Pereiro, L. de Jong (C), Locadia (66. L. Narsingh).
Subs: Pasveer – Bergwijn, Maher, H. Moreno, L. Narsingh, S. Poulsen, Schaars.
Coach:
Referees:
Attendance:
PSV Eindhoven substitution: Jorrit Hendrix is replaced by Adam Maher.