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All times are CEST (UTC + 2)
| Stoke – Manchester City | 1:4 (end) | | | Swansea – Hull City | 0:2 (end) | | | Tottenham – Crystal Palace | 1:0 (end) |
| Watford – Chelsea | 1:2 (end) | | | West Brom – Everton | 1:2 (end) | | | Burnley – Liverpool | 2:0 (end) |
| Leicester – Arsenal | 0:0 (end) |
| Barcelona – Betis | 6:2 (end) | | | Granada – Villarreal | 1:1 (end) | | | Sevilla – Espanyol | 6:4 (end) |
| Kerkrade – Arnhem | 0:1 (end) | | | Ajax – Willem II | 1:2 (end) | | | Zwolle – Eindhoven | 0:4 (end) |
| Nijmegen – Heerenveen | 2:1 (end) |
| Kortrijk – Club Bruggy | 2:1 (end) | | | Mouscron – Sint-Truiden | 2:1 (end) | | | Waasland-Beveren – Mechelen | 2:2 (end) |
| Waregem – Oostende | 1:1 (end) |
| Marítimo – Guimarães | 0:2 (end) | | | FC Ferreira – Sporting | 0:1 (end) | | | Porto – Estoril | 1:0 (end) |
| Salzburg – Mattersburg | 3:1 (end) | | | Admira – Ried | 1:0 (end) | | | St. Pölten – Sturm Graz | 1:3 (end) |
| Ufa – Grozny | 1:3 (end) | | | FC Zenit – CSKA Moskva | 1:1 (end) | | | Rostov – Tomsk | 3:0 (end) |
| Slovácko – Bohemians 1905 | 2:0 (end) | | | Hr. Králové – Jihlava | 1:0 (end) | | | Karviná – Dukla Praha | 2:1 (end) |
| Plzeň – Zlín | 0:2 (end) |
| Slovan Bratislava – Žilina | 1:0 (end) | | | Senica – Podbrezová | 0:1 (end) | | | Michalovce – Dunajská Streda | 1:0 (end) |
| Myjava – Trnava | 1:1 (end) |
final
Tottenham Hotspur
1:0
(0:0)
Crystal Palace FC
Goals:
83. Wanyama (Kane)
Ball possession: 58 % : 42 %.
Shots on target: 5:1. Shots off target: 9:5. Corners: 10:4. Offsides: 2:0. Fouls: 17:7.
Referees: Oliver – Beswick, Burt.
Attendance:
Cards: 60. Walker (TOT), 68. Vertonghen (TOT), 77. Dier (TOT) – 26. Zaha (CRP), 66. Dann (CRP), 88. Townsend (CRP)
Penalty missed:
Ball possession: 58 % : 42 %.
Shots on target: 5:1. Shots off target: 9:5. Corners: 10:4. Offsides: 2:0. Fouls: 17:7.
Tottenham Hotspur:
Vorm – Walker, Alderweireld, Vertonghen, Rose – Dier, Wanyama – Lamela (90+5. Carroll), Kane (90. Onomah), Eriksen (68. Alli) – V. Janssen.
Subs: McGee – R. Mason, Onomah, Alli, Carroll, Carter-Vickers, Davies.
Coach:
Crystal Palace FC: Hennessey – J. Ward, Dann, Delaney (82. Tomkins), Souaré – Ledley (46. Cabaye), Puncheon – Townsend, Čung-Jong (82. Mutch), Zaha – Wickham.
Subs: Speroni – Tomkins, Mutch, Ladapo, Kelly, Anderson, Cabaye.
Coach:
Subs: McGee – R. Mason, Onomah, Alli, Carroll, Carter-Vickers, Davies.
Coach:
Crystal Palace FC: Hennessey – J. Ward, Dann, Delaney (82. Tomkins), Souaré – Ledley (46. Cabaye), Puncheon – Townsend, Čung-Jong (82. Mutch), Zaha – Wickham.
Subs: Speroni – Tomkins, Mutch, Ladapo, Kelly, Anderson, Cabaye.
Coach:
Referees: Oliver – Beswick, Burt.
Attendance:
Crystal Palace FC substitution: Damien Delaney is replaced by James Tomkins.