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All times are CEST (UTC + 2)
| West Brom – Arsenal | 3:1 (end) | | | Crystal Palace – Watford | 1:0 (end) | | | Everton – Hull City | 4:0 (end) |
| Stoke – Chelsea | 1:2 (end) | | | Sunderland – Burnley | 0:0 (end) | | | West Ham – Leicester | 2:3 (end) |
| Bournemouth – Swansea | 2:0 (end) |
| Eibar – Espanyol | 1:1 (end) | | | Bilbao – Real | 1:2 (end) | | | Alavés – Real Sociedad | 1:0 (end) |
| Betis – Osasuna | 2:0 (end) |
| Wolfsburg – Darmstadt | 1:0 (end) | | | Kolín nad Rýnem – Hertha | 4:2 (end) | | | Augsburg – Freiburg | 1:1 (end) |
| Bremen – RB Leipzig | 3:0 (end) | | | Hoffenheim – Leverkusen | 1:0 (end) | | | Frankfurt – Hamburg | 0:0 (end) |
| Groningen – Willem II | 1:1 (end) | | | Nijmegen – Utrecht | 0:3 (end) | | | Eindhoven – Arnhem | 1:0 (end) |
| Sparta Rotterdam – Heracles | 3:1 (end) |
| Belenenses – Braga | 1:2 (end) | | | Moreirense – Tondela | 1:1 (end) | | | Sporting – Nacional | 2:0 (end) |
| FC Ferreira – SL Benfica | 0:0 (end) |
| Rapid – Mattersburg | 1:1 (end) | | | Admira – Sturm Graz | 1:0 (end) | | | Wolfsberger – St. Pölten | 1:0 (end) |
| Ried – Rheindorf Altach | 2:0 (end) |
| Tomsk – Perm | 1:0 (end) | | | Ural – Kazaň | 1:0 (end) | | | Lok. Moskva – Spartak | 1:1 (end) |
| Teplice – Příbram | 3:0 (end) | | | Liberec – Slavia | 1:1 (end) | | | Slovácko – Mladá Boleslav | 2:1 (end) |
| Žilina – Ružomberok | 3:1 (end) | | | Slovan Bratislava – Zlaté Moravce | 1:1 (end) |
Goals:
4. R. Navarro (Mandi), 28. Rubén Castro (R. Navarro)
Referees: Álvarez – Barranco, Méndez
Attendance:
Cards: 51. Mérida (OSS), 60. Buñuel (OSS)
Penalty missed:
Real Betis:
Adán – R. Navarro, Mandi, Pezzella, Tosca, Durmisi – Brašanac, Pardo (82. Donk), D. Ceballos (88. Petros) – A. Sanabria, Rubén Castro (66. Joaquín).
Subs: D. Giménez – Á. Martínez, Martin, Petros, Donk, Joaquín, Alegría.
Coach:
CA Osasuna: Sirigu – Buñuel, Oier, Vujadinović, C. Clerc – R. Torres (75. De las Cuevas), Loé, Mérida (70. Čaušić), Romero – León (75. O. Riera), Kenan.
Subs: N. Pérez – D. García, Čaušić, O. Riera, Rivière, Fuentes, De las Cuevas.
Coach:
Subs: D. Giménez – Á. Martínez, Martin, Petros, Donk, Joaquín, Alegría.
Coach:
CA Osasuna: Sirigu – Buñuel, Oier, Vujadinović, C. Clerc – R. Torres (75. De las Cuevas), Loé, Mérida (70. Čaušić), Romero – León (75. O. Riera), Kenan.
Subs: N. Pérez – D. García, Čaušić, O. Riera, Rivière, Fuentes, De las Cuevas.
Coach:
Referees: Álvarez – Barranco, Méndez
Attendance:
Scorer is RUBÉN CASTRO. Assisted by Rafa Navarro.
Scorer is RAFA NAVARRO. Assisted by Aïssa Mandi.