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All times are CEST (UTC + 2)
| Southampton – Chelsea | 2:3 (end) | | | Burnley – Leicester | 2:1 (end) | | | Huddersfield Town – Watford | 1:0 (end) |
| Swansea – Everton | 1:1 (end) | | | Liverpool – Bournemouth | 3:0 (end) | | | Tottenham – Manchester City | 1:3 (end) |
| Sevilla – Villarreal | 2:2 (end) | | | Barcelona – Valencia | 2:1 (end) | | | Las Palmas – Real Sociedad | 0:1 (end) |
| Leganés – Celta Vigo | 1:0 (end) | | | Bilbao – La Coruňa | 2:3 (end) |
| Hoffenheim – Hamburg | 2:0 (end) | | | Hertha – Kolín nad Rýnem | 2:1 (end) | | | Leverkusen – Frankfurt | 4:1 (end) |
| Stuttgart – Hannover | 1:1 (end) | | | Bayern – Mönchengladbach | 5:1 (end) |
| Den Haag – Twente | 2:1 (end) | | | Arnhem – Sparta Rotterdam | 7:0 (end) | | | Venlo – Heerenveen | 0:2 (end) |
| Zwolle – Excelsior | 1:1 (end) |
| Waregem – Mouscron | 5:1 (end) | | | Lierse – Kortrijk | 0:2 (end) | | | Lokeren – Eupen | 3:0 (end) |
| Waasland-Beveren – Leuven | 0:2 (end) | | | Standard – Gent | 1:0 (end) |
| Portimonense – Estoril | 0:1 (end) | | | Aves – Feirense | 1:0 (end) | | | Boavista – Chaves | 3:3 (end) |
| Guimarães – Setúbal | 1:1 (end) |
| Sturm Graz – Mattersburg | 3:0 (end) | | | Rheindorf Altach – Wolfsberger | 2:1 (end) | | | St. Pölten – Linz | 1:3 (end) |
| Perm – Kazaň | 0:3 (end) | | | Dynamo – Lok. Moskva | 0:4 (end) | | | FC Zenit – Machačkala | 1:0 (end) |
| FK Krasnodar – Arsenal Tula | 3:0 (end) |
| Jablonec – Olomouc | 0:0 (end) | | | Ostrava – Bohemians 1905 | 2:0 (end) | | | Slovácko – Brno | 1:0 (end) |
| Dukla Praha – Liberec | 2:0 (end) |
| Slovan Bratislava – Trenčín | 1:3 (end) | | | Dunajská Streda – Žilina | 3:1 (end) | | | Michalovce – Zlaté Moravce | 2:0 (end) |
| Podbrezová – Senica | 3:1 (end) |
final
Southampton FC
2:3
(1:0)
Chelsea FC
Goals:
21. Tadić (Bertrand), 60. Bednarek (Ward-Prowse) – 70. Giroud (Alonso), 75. E. Hazard (Willian), 78. Giroud
Ball possession: 42 % : 58 %.
Shots on target: 7:5. Shots off target: 3:12. Corners: 4:7. Offsides: 1:2. Fouls: 13:14.
Referees: Dean – Hussin, Scholes
Attendance: 31 764
Cards: 42. P.-E. Höjbjerg (SOT), 44. Ward-Prowse (SOT), 65. Bertrand (SOT), 78. Romeu (SOT), 81. S. Long (SOT) – 64. E. Hazard (CHE), 82. Willian (CHE), 90+4. Cahill (CHE)
Penalty missed:
Ball possession: 42 % : 58 %.
Shots on target: 7:5. Shots off target: 3:12. Corners: 4:7. Offsides: 1:2. Fouls: 13:14.
Southampton FC:
A. McCarthy – Bednarek (90+2. Gabbiadini), Jošida, Hoedt – Soares, Romeu, P.-E. Höjbjerg, Bertrand (C) – Ward-Prowse (79. Ch. Austin), Tadić (83. Sims) – S. Long.
Subs: Forster – Ch. Austin, Gabbiadini, Boufal, Sims, Lemina, McQueen.
Coach:
Chelsea FC: Courtois – Azpilicueta, Cahill (C), Christensen – Zappacosta (61. Pedro), Fàbregas, Kanté, Alonso – Willian, E. Hazard (86. Moses) – Morata (61. Giroud).
Subs: Caballero – Barkley, Bakayoko, Giroud, Pedro, Moses, Emerson.
Coach:
Subs: Forster – Ch. Austin, Gabbiadini, Boufal, Sims, Lemina, McQueen.
Coach:
Chelsea FC: Courtois – Azpilicueta, Cahill (C), Christensen – Zappacosta (61. Pedro), Fàbregas, Kanté, Alonso – Willian, E. Hazard (86. Moses) – Morata (61. Giroud).
Subs: Caballero – Barkley, Bakayoko, Giroud, Pedro, Moses, Emerson.
Coach:
Referees: Dean – Hussin, Scholes
Attendance: 31 764
Scorer is OLIVIER GIROUD.
Scorer is EDEN HAZARD. Assisted by Willian.
Scorer is OLIVIER GIROUD. Assisted by Marcos Alonso.
Chelsea FC substitution: Davide Zappacosta is replaced by Pedro.