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All times are CEST (UTC + 2)
| Southampton – Chelsea | 2:3 (end) | | | Burnley – Leicester | 2:1 (end) | | | Huddersfield Town – Watford | 1:0 (end) |
| Swansea – Everton | 1:1 (end) | | | Liverpool – Bournemouth | 3:0 (end) | | | Tottenham – Manchester City | 1:3 (end) |
| Sevilla – Villarreal | 2:2 (end) | | | Barcelona – Valencia | 2:1 (end) | | | Las Palmas – Real Sociedad | 0:1 (end) |
| Leganés – Celta Vigo | 1:0 (end) | | | Bilbao – La Coruňa | 2:3 (end) |
| Hoffenheim – Hamburg | 2:0 (end) | | | Hertha – Kolín nad Rýnem | 2:1 (end) | | | Leverkusen – Frankfurt | 4:1 (end) |
| Stuttgart – Hannover | 1:1 (end) | | | Bayern – Mönchengladbach | 5:1 (end) |
| Den Haag – Twente | 2:1 (end) | | | Arnhem – Sparta Rotterdam | 7:0 (end) | | | Venlo – Heerenveen | 0:2 (end) |
| Zwolle – Excelsior | 1:1 (end) |
| Waregem – Mouscron | 5:1 (end) | | | Lierse – Kortrijk | 0:2 (end) | | | Lokeren – Eupen | 3:0 (end) |
| Waasland-Beveren – Leuven | 0:2 (end) | | | Standard – Gent | 1:0 (end) |
| Portimonense – Estoril | 0:1 (end) | | | Aves – Feirense | 1:0 (end) | | | Boavista – Chaves | 3:3 (end) |
| Guimarães – Setúbal | 1:1 (end) |
| Sturm Graz – Mattersburg | 3:0 (end) | | | Rheindorf Altach – Wolfsberger | 2:1 (end) | | | St. Pölten – Linec | 1:3 (end) |
| Perm – Kazaň | 0:3 (end) | | | Dynamo – Lok. Moskva | 0:4 (end) | | | FC Zenit – Machačkala | 1:0 (end) |
| FK Krasnodar – Arsenal Tula | 3:0 (end) |
| Jablonec – Olomouc | 0:0 (end) | | | Ostrava – Bohemians 1905 | 2:0 (end) | | | Slovácko – Brno | 1:0 (end) |
| Dukla Praha – Liberec | 2:0 (end) |
| Slovan Bratislava – Trenčín | 1:3 (end) | | | Dunajská Streda – Žilina | 3:1 (end) | | | Michalovce – Zlaté Moravce | 2:0 (end) |
| Podbrezová – Senica | 3:1 (end) |
final
Tottenham Hotspur
1:3
(1:2)
Manchester City
Goals:
42. Eriksen – 22. Jesus (Kompany), 25. Gündoğan (pen.), 72. Sterling
Ball possession: 48 % : 52 %.
Shots on target: 3:6. Shots off target: 1:5. Corners: 5:7. Offsides: 5:1. Fouls: 11:12.
Referees: Jonathan Moss – Simon Bennett, Andy Halliday
Attendance: 80811
Cards: 24. Lloris (TOT), 27. Davies (TOT), 70. M. Dembélé (TOT) – 41. De Bruyne (MAC), 45+1. Jesus (MAC), 66. Kompany (MAC), 77. Delph (MAC)
Penalty missed:
Ball possession: 48 % : 52 %.
Shots on target: 3:6. Shots off target: 1:5. Corners: 5:7. Offsides: 5:1. Fouls: 11:12.
Tottenham Hotspur:
Lloris (C) – Trippier, D. Sánchez, Vertonghen, Davies – Dier, M. Dembélé (73. Lucas Moura) – Eriksen, Alli (84. Moussa Sissoko), Lamela (64. Son) – Kane.
Subs: Vorm – Aurier, Wanyama, Moussa Sissoko, Lucas Moura, Son, Sterling.
Coach:
Manchester City: Ederson – Walker, Laporte, Kompany (C), Delph – Gündoğan, D. Silva, De Bruyne (89. Y. Touré) – Sterling, Jesus (76. B. Silva), Sané (64. Otamendi).
Subs: Bravo – B. Silva, Otamendi, Zinčenko, Y. Touré, Foden, Díaz.
Coach:
Subs: Vorm – Aurier, Wanyama, Moussa Sissoko, Lucas Moura, Son, Sterling.
Coach:
Manchester City: Ederson – Walker, Laporte, Kompany (C), Delph – Gündoğan, D. Silva, De Bruyne (89. Y. Touré) – Sterling, Jesus (76. B. Silva), Sané (64. Otamendi).
Subs: Bravo – B. Silva, Otamendi, Zinčenko, Y. Touré, Foden, Díaz.
Coach:
Referees: Jonathan Moss – Simon Bennett, Andy Halliday
Attendance: 80811
Manchester City substitution: Leroy Sané is replaced by Nicolás Otamendi.