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All times are CEST (UTC + 2)
| Manchester City – Tottenham | 1:0 (end) | | | Huddersfield Town – Watford | 1:2 (end) | | | West Ham – Leicester | 2:2 (end) |
| Newcastle – Southampton | 3:1 (end) |
| Celta Vigo – Girona | 2:1 (end) | | | Eibar – Atlético | 0:1 (end) | | | Rayo Vallecano – Huesca | 0:0 (end) |
| Barcelona – Real Sociedad | 2:1 (end) |
| Augsburg – Stuttgart | 6:0 (end) | | | Bayern – Bremen | 1:0 (end) | | | Leverkusen – Norimberk | 2:0 (end) |
| Mohuč – Düsseldorf | 3:1 (end) | | | Mönchengladbach – RB Leipzig | 1:2 (end) | | | Schalke – Hoffenheim | 2:5 (end) |
| Emmen – Utrecht | 2:0 (end) | | | Groningen – Ajax | 0:1 (end) | | | Arnhem – Zwolle | 4:1 (end) |
| Feyenoord – Alkmaar | 2:1 (end) | | | Venlo – Graafschap | 4:1 (end) |
| St.Gilloise – Waregem | 2:2 (end) | | | Westerlo – Oostende | 0:0 (end) | | | Eupen – Sint-Truiden | 1:1 (end) |
| Moreirense – Chaves | 0:1 (end) | | | Belenenses – Rio Ave | 1:3 (end) | | | Feirense – Braga | 0:2 (end) |
| Porto – Santa Clara | 1:0 (end) |
| Admira – Hartberg | 2:1 (end) | | | Rheindorf Altach – Rapid | 2:2 (end) | | | Mattersburg – Wacker | 3:1 (end) |
| Ufa – Arsenal Tula | 1:2 (end) | | | Orenburg – Rostov | 3:0 (end) | | | Dynamo – Samara | 1:0 (end) |
| Lok. Moskva – CSKA Moskva | 1:1 (end) | | | FK Krasnodar – FC Zenit | 2:3 (end) |
| Žilina – Sereď | 1:2 (end) | | | Michalovce – Dunajská Streda | 0:2 (end) | | | Trnava – Senica | 0:1 (end) |
| Podbrezová – Trenčín | 0:0 (end) | | | Nitra – Zlaté Moravce | 2:2 (end) |
| Trabzonspor – Yeni Malatyaspor | 2:1 (end) | | | Akhisarspor – Antalyaspor | 1:2 (end) | | | Galatasaray AŞ – Kayserispor | 3:1 (end) |
| Göztepe – BB Erzurumspor | 0:1 (end) |
final
Newcastle United
3:1
(2:0)
Southampton FC
Goals:
27. Ayoze Pérez (Hayden), 31. Ayoze Pérez (Rondón), 86. Ayoze Pérez (Ritchie) – 59. Lemina (Armstrong)
Ball possession: 43 % : 57 %.
Shots on target: 6:3. Shots off target: 3:7. Corners: 4:11. Offsides: 0:2. Fouls: 5:11.
Referees: Taylor – Beswick, Nunn
Attendance: 52 191
Cards: 23. Ward-Prowse (SOT), 62. Romeu (SOT)
Penalty missed:
Ball possession: 43 % : 57 %.
Shots on target: 6:3. Shots off target: 3:7. Corners: 4:11. Offsides: 0:2. Fouls: 5:11.
Newcastle United:
Dúbravka – Manquillo, Schär (69. F. Fernández), Lascelles (C), P. Dummett, Ritchie – Ayoze Pérez, Ki Song-jung, Hayden (78. Diamé), Almirón (64. Atsu) – Rondón.
Subs: Darlow – Shelvey, Diamé, Muto, F. Fernández, Yedlin, Atsu.
Coach:
Southampton FC: Gunn – Bednarek, Jošida, J. Stephens (46. Lemina) – Ward-Prowse, Romeu, P.-E. Höjbjerg (C), Bertrand – Sims (46. Armstrong), Ings (76. S. Long), Redmond.
Subs: Forster – S. Long, Ch. Austin, Armstrong, Lemina, Slattery, Ramsay.
Coach:
Subs: Darlow – Shelvey, Diamé, Muto, F. Fernández, Yedlin, Atsu.
Coach:
Southampton FC: Gunn – Bednarek, Jošida, J. Stephens (46. Lemina) – Ward-Prowse, Romeu, P.-E. Höjbjerg (C), Bertrand – Sims (46. Armstrong), Ings (76. S. Long), Redmond.
Subs: Forster – S. Long, Ch. Austin, Armstrong, Lemina, Slattery, Ramsay.
Coach:
Referees: Taylor – Beswick, Nunn
Attendance: 52 191
Southampton FC substitution: Jack Stephens is replaced by Mario Lemina.