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All times are CEST (UTC + 2)
| Levante – Atlético | 2:2 (end) | | | Espanyol – Real Sociedad | 2:0 (end) | | | Getafe – Villarreal | 2:2 (end) |
| Sevilla – Bilbao | 2:0 (end) | | | Valladolid – Valencia | 0:2 (end) | | | Alavés – Girona | 2:1 (end) |
| Celta Vigo – Rayo Vallecano | 2:2 (end) | | | Huesca – Leganés | 2:1 (end) |
| Bayern – Frankfurt | 5:1 (end) | | | Bremen – RB Leipzig | 2:1 (end) | | | Düsseldorf – Hannover | 2:1 (end) |
| Freiburg – Norimberk | 5:1 (end) | | | Hertha – Leverkusen | 1:5 (end) | | | Mohuč – Hoffenheim | 4:2 (end) |
| Mönchengladbach – Dortmund | 0:2 (end) | | | Schalke – Stuttgart | 0:0 (end) | | | Wolfsburg – Augsburg | 8:1 (end) |
| Heracles – Utrecht | 0:2 (end) | | | Groningen – Arnhem | 2:1 (end) |
| Charleroi – Eupen | 2:0 (end) | | | Beerschot – Oostende | 1:2 (end) | | | Sint-Truiden – Westerlo | 2:1 (end) |
| Feirense – Aves | 2:1 (end) | | | Marítimo – Boavista | 0:1 (end) | | | Setúbal – Rio Ave | 1:3 (end) |
| SL Benfica – Santa Clara | 4:1 (end) | | | Porto – Sporting | 2:1 (end) |
| Admira – Wacker | 3:2 (end) | | | Rheindorf Altach – Hartberg | 3:1 (end) | | | Mattersburg – Rapid | 1:0 (end) |
| Ufa – Orenburg | 0:2 (end) | | | CSKA Moskva – Grozny | 1:0 (end) | | | Samara – Spartak | 1:2 (end) |
| Michalovce – Slovan Bratislava | 3:3 (end) | | | Sereď – Žilina | 2:3 (end) | | | Ružomberok – Dunajská Streda | 1:0 (end) |
| Senica – Zlaté Moravce | 3:1 (end) | | | Nitra – Trnava | 0:1 (end) | | | Trenčín – Podbrezová | 4:0 (end) |
| Manchester City – Watford | 6:0 (end) |
| Antalyaspor – Yeni Malatyaspor | 3:0 (end) | | | Trabzonspor – Beşiktaş | 2:1 (end) |
Goals:
62. Edinho, 77. João Silva – 31. Jorge Fellipe
Referees: Andre Filipe Domingues Narciso
Attendance:
Cards: 41. Tiago Silva (FEI), 74. Farias (FEI) – 83. Galo (CDA)
Penalty missed:
CD Feirense:
Secco – Nascimento, Mesquita (46. Edinho), V. Bruno, Briseňo – Soares (46. L. Machado), Babanco – Tiago Silva, João Silva, Farias – Anderson (76. Crivellaro).
Subs: Brigido – Ghazal, Crivellaro, Cris, L. Machado, Petkov, Edinho.
Coach:
CD Aves: A. Ferreira (78. Fábio) – Jorge Fellipe, Miloš, Galo – Rodrigo, V. Gomes (60. Lourenço), Falcao, Rodrigues – Luquinhas (60. Derley), Varela, Tavares.
Subs: Fábio – Erik, Ponck, Diallo, Braga, Derley, Lourenço.
Coach:
Subs: Brigido – Ghazal, Crivellaro, Cris, L. Machado, Petkov, Edinho.
Coach:
CD Aves: A. Ferreira (78. Fábio) – Jorge Fellipe, Miloš, Galo – Rodrigo, V. Gomes (60. Lourenço), Falcao, Rodrigues – Luquinhas (60. Derley), Varela, Tavares.
Subs: Fábio – Erik, Ponck, Diallo, Braga, Derley, Lourenço.
Coach:
Referees: Andre Filipe Domingues Narciso
Attendance:
CD Aves substitution: Luquinhas is replaced by Derley.
CD Feirense substitution: Tiago Mesquita is replaced by Edinho.