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All times are CEST (UTC + 2)
| Villarreal – Granada | 2:0 (end) | | | Alavés – Atlético | 0:0 (end) | | | Eibar – La Coruňa | 3:1 (end) |
| Leganés – Celta Vigo | 0:2 (end) |
| Wolfsburg – Augsburg | 1:2 (end) | | | Ingolstadt – Hamburg | 3:1 (end) | | | Bremen – Bayern | 1:2 (end) |
| Darmstadt – Kolín nad Rýnem | 1:6 (end) | | | RB Leipzig – Hoffenheim | 2:1 (end) | | | Leverkusen – Mönchengladbach | 2:3 (end) |
| GA Eagles – Utrecht | 0:1 (end) | | | Heracles – Eindhoven | 1:2 (end) | | | Kerkrade – Excelsior | 4:0 (end) |
| Kortrijk – Lokeren | 2:1 (end) | | | Waasland-Beveren – Westerlo | 0:0 (end) | | | Sint-Truiden – Oostende | 3:0 (end) |
| Mechelen – Genk | 1:0 (end) |
| Tondela – Chaves | 2:0 (end) | | | Nacional – Arouca | 1:1 (end) | | | Guimarães – Marítimo | 0:0 (end) |
| Estoril – Porto | 1:2 (end) | | | Sporting – FC Ferreira | 4:2 (end) |
| Liverpool – Wolverhampton | 1:2 (end) | | | Burnley – Bristol | 2:0 (end) | | | Crystal Palace – Manchester City | 0:3 (end) |
| Tottenham – Wycombe | 4:3 (end) | | | Middlesbrough – Accrington | 1:0 (end) | | | Southampton – Arsenal | 0:5 (end) |
| Burkina Faso – Tunisia | 2:0 (end) | | | Senegal – Cameroon | 0:0 (4:5 after SO) |
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89
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José Ángel Valdés (Villarreal CF) is shown a yellow card.
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75
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Gastón Silva (Granada CF) is shown a yellow card.
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48
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Sergi Samper (Granada CF) is shown a yellow card.
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40
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Roberto Soriano (Villarreal CF) is shown a yellow card.
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38
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Álvaro González (Villarreal CF) is shown a yellow card.
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Goals:
42. B. Soriano (Álvaro González), 73. Álvaro González (N. Sansone)
Ball possession: 70 % : 30 %.
Shots on target: 6:0. Shots off target: 9:4. Corners: 7:4. Offsides: 3:1. Fouls: 11:18.
Referees: Izquierdo – Trejo, Mateo
Attendance:
Cards: 38. Álvaro González (VLR), 40. R. Soriano (VLR), 89. Ángel Valdés (VLR) – 48. Samper (GRN), 75. G. Silva (GRN)
Penalty missed:
Ball possession: 70 % : 30 %.
Shots on target: 6:0. Shots off target: 9:4. Corners: 7:4. Offsides: 3:1. Fouls: 11:18.
Villarreal CF:
Asenjo – M. Gaspar, Álvaro González, Bonera, Ángel Valdés – Trigueros, B. Soriano – J. dos Santos, R. Soriano (63. Adrián López), Castillejo (80. Suárez) – N. Sansone (87. Hernández Cascante).
Subs: Andrés Fernández – Suárez, Antonio Rukavina, N'Diaye, Hernández Cascante, Borré, Adrián López.
Coach:
Granada CF: Ochoa – Foulquier, Hongla, Saunier (74. Kravec), Ingason, G. Silva – Cuenca, Samper, Malle (82. Atzili) – Ramos, Ponce (59. Boga).
Subs: da Silva – Atzili, Kravec, Krhin, Lombán, Boga, Tabanou.
Coach:
Subs: Andrés Fernández – Suárez, Antonio Rukavina, N'Diaye, Hernández Cascante, Borré, Adrián López.
Coach:
Granada CF: Ochoa – Foulquier, Hongla, Saunier (74. Kravec), Ingason, G. Silva – Cuenca, Samper, Malle (82. Atzili) – Ramos, Ponce (59. Boga).
Subs: da Silva – Atzili, Kravec, Krhin, Lombán, Boga, Tabanou.
Coach:
Referees: Izquierdo – Trejo, Mateo
Attendance: