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All times are CEST (UTC + 2)
| Tottenham – Bournemouth | 4:0 (end) | | | Crystal Palace – Leicester | 2:2 (end) | | | Everton – Burnley | 3:1 (end) |
| Stoke – Hull City | 3:1 (end) | | | Sunderland – West Ham | 2:2 (end) | | | Watford – Swansea | 1:0 (end) |
| Southampton – Manchester City | 0:3 (end) |
| La Coruňa – Malaga | 2:0 (end) | | | Gijón – Real | 2:3 (end) | | | Atlético – Osasuna | 3:0 (end) |
| Barcelona – Real Sociedad | 3:2 (end) |
| Dortmund – Frankfurt | 3:1 (end) | | | Mohuč – Hertha | 1:0 (end) | | | Wolfsburg – Ingolstadt | 3:0 (end) |
| Augsburg – Kolín nad Rýnem | 2:1 (end) | | | Hoffenheim – Mönchengladbach | 5:3 (end) | | | RB Leipzig – Freiburg | 4:0 (end) |
| Leverkusen – Bayern | 0:0 (end) |
| Kerkrade – Sparta Rotterdam | 3:1 (end) | | | Den Haag – Eindhoven | 1:1 (end) | | | Excelsior – Arnhem | 1:0 (end) |
| Twente – Nijmegen | 3:0 (end) |
| Waasland-Beveren – Mechelen | 1:2 (end) | | | Eupen – Lokeren | 3:3 (end) | | | Roeselare – Mouscron | 3:5 (end) |
| Sint-Truiden – Lierse | 2:1 (end) |
| Arouca – Feirense | 2:0 (end) | | | Chaves – Guimarães | 2:3 (end) | | | Tondela – Rio Ave | 2:1 (end) |
| Braga – Porto | 1:1 (end) |
| Wolfsberger – Salzburg | 0:2 (end) | | | Rapid – Rheindorf Altach | 3:0 (end) | | | Admira – St. Pölten | 2:0 (end) |
| Sturm Graz – Ried | 1:0 (end) |
| Perm – Ufa | 1:1 (end) | | | CSKA Moskva – Rostov | 0:0 (end) | | | Machačkala – Samara | 1:3 (end) |
| Kazaň – FK Krasnodar | 0:1 (end) |
| Brno – Jablonec | 2:0 (end) | | | Příbram – Karviná | 4:2 (end) | | | Zlín – Teplice | 0:2 (end) |
| Mladá Boleslav – Bohemians 1905 | 1:1 (end) | | | Jihlava – Sparta | 1:0 (end) |
| Trenčín – Dunajská Streda | 0:1 (end) | | | Podbrezová – Michalovce | 1:4 (end) | | | Zlaté Moravce – Senica | 2:1 (end) |
final
Southampton FC
0:3
(0:0)
Manchester City
|
89
|
Manchester City substitution: Sergio Agüero is replaced by Kelechi Iheanacho.
|
|
|
86
|
Manchester City substitution: Leroy Sané is replaced by Raheem Sterling.
|
|
|
82
|
Southampton FC substitution: Shane Long is replaced by Jay Rodriguez.
|
|
|
81
|
Manchester City substitution: David Silva is replaced by Pablo Zabaleta.
|
|
|
60
|
Southampton FC substitution: Manolo Gabbiadini is replaced by Sofiane Boufal.
|
|
|
60
|
Southampton FC substitution: James Ward-Prowse is replaced by Shane Long.
|
Goals:
55. Kompany (Silva), 77. Sané (De Bruyne), 80. Agüero (De Bruyne)
Ball possession: 42 % : 58 %.
Shots on target: 1:5. Shots off target: 4:7. Corners: 4:8. Offsides: 0:0. Fouls: 9:8.
Referees: Swarbrick – Ledger, Holmes
Attendance:
Cards: 31. Højbjerg (SOT), 37. S. Davis (SOT), 41. Soares (SOT)
Penalty missed:
Ball possession: 42 % : 58 %.
Shots on target: 1:5. Shots off target: 4:7. Corners: 4:8. Offsides: 0:0. Fouls: 9:8.
Southampton FC:
Forster – Soares, Stephens, Jošida, Bertrand – S. Davis (C), Højbjerg – Ward-Prowse (60. S. Long, 82. Jay Rodriguez), Tadić, Redmond – Gabbiadini (60. Boufal).
Subs: Hassen – S. Long, Jay Rodriguez, Clasie, Cáceres, Martina, Boufal.
Coach:
Manchester City: Bravo – Navas, Kompany (C), Otamendi, Clichy – Y. Touré, Fernandinho – De Bruyne, Silva (81. Zabaleta), Sané (86. Sterling) – Agüero (89. Iheanacho).
Subs: Caballero – Fernando, Zabaleta, Sterling, Kolarov, Iheanacho, Aleix Garcia.
Coach:
Subs: Hassen – S. Long, Jay Rodriguez, Clasie, Cáceres, Martina, Boufal.
Coach:
Manchester City: Bravo – Navas, Kompany (C), Otamendi, Clichy – Y. Touré, Fernandinho – De Bruyne, Silva (81. Zabaleta), Sané (86. Sterling) – Agüero (89. Iheanacho).
Subs: Caballero – Fernando, Zabaleta, Sterling, Kolarov, Iheanacho, Aleix Garcia.
Coach:
Referees: Swarbrick – Ledger, Holmes
Attendance: