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All times are CEST (UTC + 2)
| West Ham – Tottenham | 2:3 (end) | | | Burnley – Huddersfield Town | 0:0 (end) | | | Everton – Bournemouth | 2:1 (end) |
| Manchester City – Crystal Palace | 5:0 (end) | | | Southampton – Man Utd. | 0:1 (end) | | | Stoke – Chelsea | 0:4 (end) |
| Swansea – Watford | 1:2 (end) | | | Leicester – Liverpool | 2:3 (end) |
| Atlético – Sevilla | 2:0 (end) | | | Alavés – Real | 1:2 (end) | | | Malaga – Bilbao | 3:3 (end) |
| Girona – Barcelona | 0:3 (end) |
| RB Leipzig – Frankfurt | 2:1 (end) | | | Hoffenheim – Schalke | 2:0 (end) | | | Bremen – Freiburg | 0:0 (end) |
| Mohuč – Hertha | 1:0 (end) | | | Stuttgart – Augsburg | 0:0 (end) | | | Dortmund – Mönchengladbach | 6:1 (end) |
| Willem II – Heerenveen | 1:2 (end) | | | Feyenoord – Breda | 0:2 (end) | | | Heracles – Kerkrade | 2:1 (end) |
| Den Haag – Sparta Rotterdam | 1:0 (end) |
| Genk – Oostende | 1:1 (end) | | | Mouscron – Eupen | 3:2 (end) | | | Mechelen – Sint-Truiden | 2:0 (end) |
| Waasland-Beveren – Anderlecht | 1:2 (end) |
| Estoril – Chaves | 0:2 (end) | | | Moreirense – Sporting | 1:1 (end) | | | SL Benfica – FC Ferreira | 2:0 (end) |
| Rapid – Wolfsberger | 4:2 (end) | | | Sturm Graz – Rheindorf Altach | 0:0 (end) | | | St. Pölten – Admira | 1:1 (end) |
| Linec – Mattersburg | 2:2 (end) |
| Dynamo – CSKA Moskva | 0:0 (end) | | | Spartak – Machačkala | 2:2 (end) |
| Zlín – Slavia | 1:1 (end) | | | Bohemians 1905 – Jablonec | 0:1 (end) | | | Olomouc – Dukla Praha | 3:0 (end) |
| Mladá Boleslav – Plzeň | 0:2 (end) |
| Zlaté Moravce – Podbrezová | 1:0 (end) | | | Senica – Trnava | 1:3 (end) |
final
Southampton FC
0:1
(0:1)
Manchester United
|
90+3
|
Manchester United substitution: Marcus Rashford is replaced by Daley Blind.
|
|
|
83
|
Southampton FC substitution: Cédric Soares is replaced by James Ward-Prowse.
|
|
|
83
|
Southampton FC substitution: Shane Long is replaced by Charlie Austin.
|
|
|
75
|
Manchester United substitution: Henrich Mchitarjan is replaced by Chris Smalling.
|
|
|
73
|
Southampton FC substitution: Steven Davis is replaced by Manolo Gabbiadini.
|
|
|
63
|
Manchester United substitution: Juan Mata is replaced by Ander Herrera.
|
Goals:
20. R. Lukaku
Ball possession: 61 % : 39 %.
Shots on target: 4:4. Shots off target: 6:3. Corners: 8:4. Offsides: 3:2. Fouls: 12:9.
Referees: Pawson – Hussin, Hatzidakis
Attendance:
Cards: 37. S. Long (SOT) – 43. Young (MAN), 70. A. Valencia (MAN), 82. R. Lukaku (MAN), 88. A. Herrera (MAN)
Penalty missed:
Ball possession: 61 % : 39 %.
Shots on target: 4:4. Shots off target: 6:3. Corners: 8:4. Offsides: 3:2. Fouls: 12:9.
Southampton FC:
Forster – Soares (83. Ward-Prowse), Hoedt, Jošida, Bertrand – Lemina, Romeu – Tadić, S. Davis (C) (73. Gabbiadini), Redmond – S. Long (83. Ch. Austin).
Subs: A. McCarthy – Gabbiadini, Ch. Austin, P.-E. Höjbjerg, Pied, V. van Dijk, Ward-Prowse.
Coach:
Manchester United: de Gea – A. Valencia (C), Bailly, P. Jones, Young – N. Matić, Fellaini – Mata (63. A. Herrera), Mchitarjan (75. Smalling), Rashford (90+3. Blind) – R. Lukaku.
Subs: Romero – Blind, Carrick, A. Herrera, Lingard, Martial, Smalling.
Coach:
Subs: A. McCarthy – Gabbiadini, Ch. Austin, P.-E. Höjbjerg, Pied, V. van Dijk, Ward-Prowse.
Coach:
Manchester United: de Gea – A. Valencia (C), Bailly, P. Jones, Young – N. Matić, Fellaini – Mata (63. A. Herrera), Mchitarjan (75. Smalling), Rashford (90+3. Blind) – R. Lukaku.
Subs: Romero – Blind, Carrick, A. Herrera, Lingard, Martial, Smalling.
Coach:
Referees: Pawson – Hussin, Hatzidakis
Attendance: