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All times are CEST (UTC + 2)
| Bournemouth – Man Utd. | 1:2 (end) | | | Newcastle – Watford | 1:0 (end) | | | West Ham – Burnley | 4:2 (end) |
| Arsenal – Liverpool | 1:1 (end) | | | Wolverhampton – Tottenham | 2:3 (end) |
| Leganés – Atlético | 1:1 (end) | | | Real – Valladolid | 2:0 (end) | | | Valencia – Girona | 0:1 (end) |
| Rayo Vallecano – Barcelona | 2:3 (end) |
| Augsburg – Norimberk | 2:2 (end) | | | Bayern – Freiburg | 1:1 (end) | | | Leverkusen – Hoffenheim | 1:4 (end) |
| Schalke – Hannover | 3:1 (end) | | | Wolfsburg – Dortmund | 0:1 (end) | | | Hertha – RB Leipzig | 0:3 (end) |
| Breda – Heracles | 2:1 (end) | | | Eindhoven – Arnhem | 1:0 (end) | | | Ajax – Willem II | 2:0 (end) |
| Alkmaar – Graafschap | 1:0 (end) |
| Genk – Club Bruggy | 1:1 (end) | | | Gent – Kortrijk | 3:1 (end) |
| Portimonense – Belenenses | 1:1 (end) | | | Marítimo – Porto | 0:2 (end) | | | Boavista – Guimarães | 0:0 (end) |
| Admira – Hartberg | 2:3 (end) | | | St. Pölten – Linec | 2:2 (end) | | | Sturm Graz – Wacker | 1:1 (end) |
| Lok. Moskva – Arsenal Tula | 3:1 (end) | | | Dynamo – CSKA Moskva | 0:0 (end) |
| Ostrava – Plzeň | 0:1 (end) | | | Příbram – Slovácko | 0:3 (end) | | | Dukla Praha – Jablonec | 2:6 (end) |
| Olomouc – Opava | 2:2 (end) | | | Zlín – Karviná | 2:1 (end) |
| Žilina – Ružomberok | 3:0 (end) | | | Trnava – Podbrezová | 2:0 (end) | | | Slovan Bratislava – Michalovce | 6:0 (end) |
| Senica – Zlaté Moravce | 3:0 (end) |
Goals:
76. M. Seuntjens
Ball possession: 71 % : 29 %.
Shots on target: 6:0. Shots off target: 10:2. Corners: 7:1. Offsides: 0:2. Fouls: 8:8.
Referees:
Attendance:
Cards: 90+4. Midtsjö (ALK)
Penalty missed:
Ball possession: 71 % : 29 %.
Shots on target: 6:0. Shots off target: 10:2. Corners: 7:1. Offsides: 0:2. Fouls: 8:8.
AZ Alkmaar:
Bizot – J. Svensson, Vlaar (61. A. Gudmundsson), Hatzidiakos, Ouwejan – Midtsjö, Til (C), Koopmeiners – Stengs (69. Johnsen), M. Seuntjens (86. Vejinović), Idrissi.
Subs: Velthuizen – A. Gudmundsson, Johnsen, Maher, Rotariu, van Rhijn, Vejinović.
Coach:
BV De Graafschap: Jurjus – Owusu (80. F. Narsingh), Straalman, Nieuwpoort (69. Abena), Nieuwpoort (C), Tutuarima – Olijve, E. Bakker, Klaasen – Serrarens, El Jebli (65. van Mieghem).
Subs: Rondeel – Abena, F. Narsingh, Nijland, Thomassen, van de Pavert, van Mieghem, Vet.
Coach:
Subs: Velthuizen – A. Gudmundsson, Johnsen, Maher, Rotariu, van Rhijn, Vejinović.
Coach:
BV De Graafschap: Jurjus – Owusu (80. F. Narsingh), Straalman, Nieuwpoort (69. Abena), Nieuwpoort (C), Tutuarima – Olijve, E. Bakker, Klaasen – Serrarens, El Jebli (65. van Mieghem).
Subs: Rondeel – Abena, F. Narsingh, Nijland, Thomassen, van de Pavert, van Mieghem, Vet.
Coach:
Referees:
Attendance:
BV De Graafschap substitution: Lars Nieuwpoort is replaced by Myenty Abena.