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All times are CEST (UTC + 2)
| Tottenham – West Ham | 0:1 (end) | | | Crystal Palace – Everton | 0:0 (end) | | | Southampton – Bournemouth | 3:3 (end) |
| Watford – Wolverhampton | 1:2 (end) |
| Bilbao – Alavés | 1:1 (end) | | | Atlético – Valladolid | 1:0 (end) | | | Leganés – Celta Vigo | 0:0 (end) |
| Barcelona – Levante | 1:0 (end) |
| Dortmund – Schalke | 2:4 (end) | | | Düsseldorf – Bremen | 4:1 (end) | | | Frankfurt – Hertha | 0:0 (end) |
| Hannover – Mohuč | 1:0 (end) | | | RB Leipzig – Freiburg | 2:1 (end) | | | Stuttgart – Mönchengladbach | 1:0 (end) |
| Oostende – Charleroi | 2:2 (end) | | | Westerlo – Eupen | 1:0 (end) | | | Mouscron – Kortrijk | 2:3 (end) |
| Waasland-Beveren – St.Gilloise | 3:2 (end) | | | Gent – Genk | 0:1 (end) |
| Santa Clara – Setúbal | 0:0 (end) | | | Portimonense – Feirense | 1:0 (end) | | | Sporting – Guimarães | 2:0 (end) |
| Aves – Belenenses | 3:0 (end) |
| Rheindorf Altach – Wacker | 1:4 (end) | | | Rapid – Hartberg | 3:4 (end) | | | Mattersburg – Admira | 1:1 (end) |
| Machačkala – Rostov | 1:1 (end) | | | Dynamo – Grozny | 0:0 (end) |
| Slovácko – Bohemians 1905 | 1:1 (end) | | | Teplice – Příbram | 0:0 (end) | | | Jablonec – Ostrava | 4:0 (end) |
| Plzeň – Dukla Praha | 4:0 (end) | | | Karviná – Liberec | 2:1 (end) | | | Opava – Sparta | 0:3 (end) |
| Slavia – Olomouc | 2:1 (end) | | | Mladá Boleslav – Zlín | 3:0 (end) |
| Dunajská Streda – Slovan Bratislava | 1:0 (end) | | | Michalovce – Žilina | 2:1 (end) | | | Senica – Trenčín | 4:0 (end) |
| Zlaté Moravce – Trnava | 1:1 (end) |
| Rennes – PSG | 2:2 (6:5 after SO) |
| Rizespor – Sivasspor | 0:0 (end) | | | Antalyaspor – BB Erzurumspor | 1:1 (end) | | | Fenerbahce – Trabzonspor | 1:1 (end) |
Goals:
12. Castaňeda, 67. Tesija (Ramírez), 90. Ramírez (Petshi), 90+4. Petshi
Referees: I. Kružliak – Somoláni, Bednár – Očenáš
Attendance: 742
Cards: 20. Ramírez (SEN), 53. Da Graca (SEN) – 45+2. Zubairu (TRE), 74. van Arnhem (TRE)
Penalty missed:
FK Senica:
Taborda – Krč, Da Graca, Dias (C), Klapan (89. Otrísal) – Asmah, Petshi – El Moudane, Tesija (71. Dangubič), Castaňeda (83. Zezinho) – Ramírez.
Subs: Vorel – Otrísal, Dubois, Zezinho, Deretti, Dangubič, Azankpo.
Coach:
AS Trenčín: Šemrinec – Keston (68. Kvocera), Kleščík (C), Skovajsa, Yem – Zubairu, van Arnhem, Čataković – Bukari, Sleegers (46. Paur), Roguljić (46. Corryn).
Subs: Chudý – Paur, Slávik, Pišoja, Mbombo, Kvocera, Laczkó, Corryn.
Coach:
Subs: Vorel – Otrísal, Dubois, Zezinho, Deretti, Dangubič, Azankpo.
Coach:
AS Trenčín: Šemrinec – Keston (68. Kvocera), Kleščík (C), Skovajsa, Yem – Zubairu, van Arnhem, Čataković – Bukari, Sleegers (46. Paur), Roguljić (46. Corryn).
Subs: Chudý – Paur, Slávik, Pišoja, Mbombo, Kvocera, Laczkó, Corryn.
Coach:
Referees: I. Kružliak – Somoláni, Bednár – Očenáš
Attendance: 742
AS Trenčín substitution: Ante Roguljić is replaced by Milan Corryn.