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All times are CEST (UTC + 2)
| Burnley – Arsenal | 1:3 (end) | | | Crystal Palace – Bournemouth | 5:3 (end) | | | Leicester – Chelsea | 0:0 (end) |
| Liverpool – Wolverhampton | 2:0 (end) | | | Southampton – Huddersfield Town | 1:1 (end) | | | Tottenham – Everton | 2:2 (end) |
| Watford – West Ham | 1:4 (end) |
| Bilbao – Celta Vigo | 3:1 (end) | | | Atlético – Sevilla | 1:1 (end) | | | Barcelona – Getafe | 2:0 (end) |
| Betis – Huesca | 2:1 (end) | | | Girona – Levante | 1:2 (end) | | | Leganés – Espanyol | 0:2 (end) |
| Real Sociedad – Real | 3:1 (end) | | | Valencia – Alavés | 3:1 (end) | | | Rayo Vallecano – Valladolid | 1:2 (end) |
| Villarreal – Eibar | 1:0 (end) |
| Frankfurt – Mohuč | 0:2 (end) |
| Ajax – Utrecht | 4:1 (end) | | | Alkmaar – Eindhoven | 1:0 (end) | | | Feyenoord – Den Haag | 0:2 (end) |
| Groningen – Sittard | 3:0 (end) | | | Heerenveen – Breda | 2:1 (end) | | | Heracles – Excelsior | 4:5 (end) |
| Arnhem – Graafschap | 6:1 (end) | | | Willem II – Emmen | 2:3 (end) | | | Zwolle – Venlo | 2:4 (end) |
| Antwerp – Anderlecht | 1:1 (end) | | | Club Bruggy – Genk | 3:2 (end) | | | Sint-Truiden – Eupen | 2:2 (end) |
| Guimarães – Belenenses | 5:1 (end) | | | Chaves – Setúbal | 1:2 (end) | | | Nacional – Porto | 0:4 (end) |
| Rio Ave – SL Benfica | 2:3 (end) |
| Wolfsberger – St. Pölten | 4:0 (end) | | | Sturm Graz – Austria | 1:3 (end) | | | Salzburg – Linz | 2:1 (end) |
| Spartak – Ufa | 1:0 (end) | | | FC Zenit – CSKA Moskva | 3:1 (end) |
| Kayserispor – Kasımpaşa | 2:1 (end) | | | Konyaspor – Trabzonspor | 2:2 (end) | | | Başakşehir – Ankaragücü | 2:1 (end) |
| Yeni Malatyaspor – BB Erzurumspor | 3:1 (end) |
Goals:
30. Koke – 70. Sarabia (F. Vázquez)
Ball possession: 48 % : 52 %.
Shots on target: 4:5. Shots off target: 5:4. Corners: 5:7. Offsides: 7:5. Fouls: 16:12.
Referees:
Attendance:
Cards: 68. Partey (ATM), 71. Morata (ATM), 81. Koke (ATM), 88. Lemar (ATM) – 59. Mesa (SEV), 75. Aleix Vidal (SEV), 85. Rog (SEV), 89. Navas (SEV)
Penalty missed:
Ball possession: 48 % : 52 %.
Shots on target: 4:5. Shots off target: 5:4. Corners: 5:7. Offsides: 7:5. Fouls: 16:12.
Atlético Madrid:
Oblak – Juanfran, Godín, Montero, Luís – Koke, Rodri (57. Á. Correa), Partey, Saúl Ñíguez – Morata (79. Lemar), Griezmann.
Subs: Adán – Arias, Á. Correa, Lemar, Mollejo, Vitolo, Moya.
Coach:
Sevilla FC: Vaclík – Navas, Kjaer (47. Aleix Vidal), Sergi Gómez, Gnagnon – Sarabia, Gonalons (36. Amadou), Mesa (78. Rog), F. Vázquez – Ben Yedder, Munir.
Subs: Soriano – Aleix Vidal, Rog, Gil, Escudero, Nolito, Amadou.
Coach:
Subs: Adán – Arias, Á. Correa, Lemar, Mollejo, Vitolo, Moya.
Coach:
Sevilla FC: Vaclík – Navas, Kjaer (47. Aleix Vidal), Sergi Gómez, Gnagnon – Sarabia, Gonalons (36. Amadou), Mesa (78. Rog), F. Vázquez – Ben Yedder, Munir.
Subs: Soriano – Aleix Vidal, Rog, Gil, Escudero, Nolito, Amadou.
Coach:
Referees:
Attendance:
Scorer is PABLO SARABIA. Assisted by Franco Vázquez.