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All times are CEST (UTC + 2)
| Burnley – Arsenal | 1:3 (end) | | | Crystal Palace – Bournemouth | 5:3 (end) | | | Leicester – Chelsea | 0:0 (end) |
| Liverpool – Wolverhampton | 2:0 (end) | | | Southampton – Huddersfield Town | 1:1 (end) | | | Tottenham – Everton | 2:2 (end) |
| Watford – West Ham | 1:4 (end) |
| Bilbao – Celta Vigo | 3:1 (end) | | | Atlético – Sevilla | 1:1 (end) | | | Barcelona – Getafe | 2:0 (end) |
| Betis – Huesca | 2:1 (end) | | | Girona – Levante | 1:2 (end) | | | Leganés – Espanyol | 0:2 (end) |
| Real Sociedad – Real | 3:1 (end) | | | Valencia – Alavés | 3:1 (end) | | | Rayo Vallecano – Valladolid | 1:2 (end) |
| Villarreal – Eibar | 1:0 (end) |
| Frankfurt – Mohuč | 0:2 (end) |
| Ajax – Utrecht | 4:1 (end) | | | Alkmaar – Eindhoven | 1:0 (end) | | | Feyenoord – Den Haag | 0:2 (end) |
| Groningen – Sittard | 3:0 (end) | | | Heerenveen – Breda | 2:1 (end) | | | Heracles – Excelsior | 4:5 (end) |
| Arnhem – Graafschap | 6:1 (end) | | | Willem II – Emmen | 2:3 (end) | | | Zwolle – Venlo | 2:4 (end) |
| Antwerp – Anderlecht | 1:1 (end) | | | Club Bruggy – Genk | 3:2 (end) | | | Sint-Truiden – Eupen | 2:2 (end) |
| Guimarães – Belenenses | 5:1 (end) | | | Chaves – Setúbal | 1:2 (end) | | | Nacional – Porto | 0:4 (end) |
| Rio Ave – SL Benfica | 2:3 (end) |
| Wolfsberger – St. Pölten | 4:0 (end) | | | Sturm Graz – Austria | 1:3 (end) | | | Salzburg – Linz | 2:1 (end) |
| Spartak – Ufa | 1:0 (end) | | | FC Zenit – CSKA Moskva | 3:1 (end) |
| Kayserispor – Kasımpaşa | 2:1 (end) | | | Konyaspor – Trabzonspor | 2:2 (end) | | | Başakşehir – Ankaragücü | 2:1 (end) |
| Yeni Malatyaspor – BB Erzurumspor | 3:1 (end) |
Goals:
73. Medrán (Á. García) – 6. Ünal (pen.), 80. Guardiola (Ünal)
Ball possession: 69 % : 31 %.
Shots on target: 4:6. Shots off target: 10:2. Corners: 4:2. Offsides: 3:2. Fouls: 13:8.
Referees:
Attendance:
Cards: 69. Á. Moreno (VLL), 76. Pozo (VLL) – 78. Olivas (RVL), 86. Plano (RVL)
Penalty missed:
Ball possession: 69 % : 31 %.
Shots on target: 4:6. Shots off target: 10:2. Corners: 4:2. Offsides: 3:2. Fouls: 13:8.
Rayo Vallecano:
Dimitrievski – Tito (C) (66. Guerra), A. Ba, Dorado (87. Comesaña), Á. Moreno (75. Trejo) – Agbo, Medrán – Bébé, Pozo, Á. García – De Tomás.
Subs: Alberto García – Advíncula, Akieme, Amat, Comesaña, Guerra, Trejo.
Coach:
Real Valladolid: Masip – Moyano (C), Olivas, F. Calero, Nacho Martínez – Plano, Míchel, Alcaraz, Rubio (61. Antoñito) – Ünal (90+1. Čop), Guardiola (82. Fernández).
Subs: Y. Rodríguez – Čop, Antoñito, T. Villa, Keko, Fernández, B. Fernández.
Coach:
Subs: Alberto García – Advíncula, Akieme, Amat, Comesaña, Guerra, Trejo.
Coach:
Real Valladolid: Masip – Moyano (C), Olivas, F. Calero, Nacho Martínez – Plano, Míchel, Alcaraz, Rubio (61. Antoñito) – Ünal (90+1. Čop), Guardiola (82. Fernández).
Subs: Y. Rodríguez – Čop, Antoñito, T. Villa, Keko, Fernández, B. Fernández.
Coach:
Referees:
Attendance:
Scorer is SERGI GUARDIOLA. Assisted by Enes Ünal.
Scorer is ÁLVARO MEDRÁN. Assisted by Álvaro García.
Scorer from a penalty shot is ENES ÜNAL..