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All times are CEST (UTC + 2)
| Tottenham – Manchester City | 4:1 (end) | | | Leicester – Arsenal | 2:5 (end) | | | Liverpool – Aston Villa | 3:2 (end) |
| Stoke – Bournemouth | 2:1 (end) | | | West Ham – Norwich | 2:2 (end) | | | Man Utd. – Sunderland | 3:0 (end) |
| Southampton – Swansea | 3:1 (end) | | | Newcastle – Chelsea | 2:2 (end) |
| Barcelona – Las Palmas | 2:1 (end) | | | Real – Malaga | 0:0 (end) | | | Sevilla – Rayo Vallecano | 3:2 (end) |
| Villarreal – Atlético | 1:0 (end) | | | Eibar – Celta Vigo | 1:1 (end) |
| Wolfsburg – Hannover | 1:1 (end) | | | Stuttgart – Mönchengladbach | 1:3 (end) | | | Augsburg – Hoffenheim | 1:3 (end) |
| Bremen – Leverkusen | 0:3 (end) | | | Mohuč – Bayern | 0:3 (end) | | | Hamburg – Schalke | 0:1 (end) |
| Heerenveen – Arnhem | 0:0 (end) | | | Utrecht – Cambuur | 3:3 (end) | | | Ajax – Groningen | 2:0 (end) |
| Alkmaar – Heracles | 3:1 (end) | | | Eindhoven – Nijmegen | 2:1 (end) |
| Waasland-Beveren – Gent | 1:3 (end) | | | Mechelen – Charleroi | 0:1 (end) | | | Mouscron – Oostende | 2:2 (end) |
| Standard – Leuven | 2:2 (end) |
| SL Benfica – FC Ferreira | 3:0 (end) | | | Boavista – Sporting | 0:0 (end) |
| Ried – Rapid | 0:1 (end) | | | Salzburg – Mattersburg | 4:2 (end) | | | Rheindorf Altach – Grödig | 1:0 (end) |
| Austria – Wolfsberger | 1:0 (end) |
| CSKA Moskva – Lok. Moskva | 1:1 (end) | | | Machačkala – Ufa | 1:1 (end) | | | Spartak – FC Zenit | 2:2 (end) |
| Olomouc – Zlín | 1:1 (end) | | | Dukla Praha – Brno | 1:2 (end) | | | Příbram – Jihlava | 4:1 (end) |
| Slovácko – Bohemians 1905 | 1:0 (end) | | | Teplice – Ostrava | 1:0 (end) | | | Plzeň – Liberec | 2:1 (end) |
| Senica – Myjava | 0:1 (end) | | | Trenčín – Skalica | 3:0 (end) | | | Ružomberok – Dunajská Streda | 1:0 (end) |
Goals:
23. Gameiro (Trémoulinas), 45+1. N'Zonzi (J. A. Reyes), 86. Konopljanka – 52. Bébé, 68. Guerra
Ball possession: 49 % : 51 %.
Shots on target: 7:5. Shots off target: 4:9. Corners: 6:5. Offsides: 2:0. Fouls: 9:15.
Referees: Hernández – Sobrino, Naranjo
Attendance:
Cards: 17. Iborra (SEV) – 15. D. Llorente (VLL), 17. Amaya (VLL), 87. Trashorras (VLL) 83. Amaya (VLL)
Penalty missed:
Ball possession: 49 % : 51 %.
Shots on target: 7:5. Shots off target: 4:9. Corners: 6:5. Offsides: 2:0. Fouls: 9:15.
Sevilla FC:
S. Rico – Coke (75. Mariano), Andreolli, Kolodziejczak, Trémoulinas – Krychowiak, N'Zonzi (74. Cristóforo), Iborra (63. Konopljanka) – J. A. Reyes, Gameiro, Krohn-Dehli.
Subs: Soria – Immobile, Cristóforo, Luismi, Konopljanka, F. Llorente, Mariano.
Coach:
Rayo Vallecano: Toño – N. Martínez, Amaya, D. Llorente, Raţ – Baena, Trashorras (85. Dorado) – Bébé, Jo. Sánchez, Embarba (65. Bangoura) – Guerra (80. Manucho).
Subs: Carlos – Dorado, Fedor, Manucho, Fariña, Quini, Bangoura.
Coach:
Subs: Soria – Immobile, Cristóforo, Luismi, Konopljanka, F. Llorente, Mariano.
Coach:
Rayo Vallecano: Toño – N. Martínez, Amaya, D. Llorente, Raţ – Baena, Trashorras (85. Dorado) – Bébé, Jo. Sánchez, Embarba (65. Bangoura) – Guerra (80. Manucho).
Subs: Carlos – Dorado, Fedor, Manucho, Fariña, Quini, Bangoura.
Coach:
Referees: Hernández – Sobrino, Naranjo
Attendance:
Scorer is JEVHEN KONOPLJANKA.
Scorer is JAVI GUERRA.
Scorer is BÉBÉ.
Scorer is STEVEN N'ZONZI. Assistant José Antonio Reyes.
Scorer is KÉVIN GAMEIRO. Assistant Benoît Trémoulinas.
Antonio Amaya (Rayo Vallecano) is shown a yellow card.