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All times are CEST (UTC + 2)
| Tottenham – Arsenal | 2:2 (end) | | | Manchester City – Aston Villa | 4:0 (end) | | | Newcastle – Bournemouth | 1:3 (end) |
| Swansea – Norwich | 1:0 (end) | | | Chelsea – Stoke | 1:1 (end) | | | Southampton – Sunderland | 1:1 (end) |
| Everton – West Ham | 2:3 (end) | | | Watford – Leicester | 0:1 (end) |
| Real – Celta Vigo | 7:1 (end) | | | Villarreal – Las Palmas | 0:1 (end) | | | Getafe – Sevilla | 1:1 (end) |
| La Coruňa – Malaga | 3:3 (end) |
| Wolfsburg – Mönchengladbach | 2:1 (end) | | | Stuttgart – Hoffenheim | 5:1 (end) | | | Augsburg – Leverkusen | 3:3 (end) |
| Bremen – Hannover | 4:1 (end) | | | Frankfurt – Ingolstadt | 1:1 (end) | | | Kolín nad Rýnem – Schalke | 1:3 (end) |
| Dortmund – Bayern | 0:0 (end) |
| Zwolle – Graafschap | 2:1 (end) | | | Groningen – Eindhoven | 0:3 (end) | | | Heerenveen – Utrecht | 0:4 (end) |
| Club Bruggy – Sint-Truiden | 3:0 (end) | | | Standard – Genk | 2:1 (end) | | | Oostende – Charleroi | 2:1 (end) |
| Mouscron – Anderlecht | 2:1 (end) | | | Lokeren – Westerlo | 2:1 (end) | | | Kortrijk – Waregem | 1:0 (end) |
| Waasland-Beveren – Mechelen | 0:0 (end) |
| Sporting – SL Benfica | 0:1 (end) |
| Salzburg – Grödig | 3:0 (end) | | | Austria – Ried | 3:1 (end) | | | Admira – Wolfsberger | 0:2 (end) |
| Mattersburg – Sturm Graz | 1:0 (end) |
| Samara – Rostov | 0:1 (end) | | | Kazaň – Kuban Krasnodar | 1:0 (end) | | | FK Krasnodar – FC Zenit | 0:0 (end) |
| Brno – Zlín | 2:0 (end) | | | Jihlava – Olomouc | 2:1 (end) | | | Bohemians 1905 – Teplice | 1:1 (end) |
| Mladá Boleslav – Slavia | 2:1 (end) |
| Skalica – Trenčín | 1:2 (end) | | | Podbrezová – Slovan Bratislava | 0:1 (end) | | | Dunajská Streda – Ružomberok | 1:1 (end) |
Goals:
33. Bittencourt – 2. Huntelaar (pen.), 24. Meyer (Højbjerg), 76. Di Santo (Aogo)
Referees:
Attendance:
Cards: 2. Maroh (KLN)
Penalty missed:
1. FC Kolín nad Rýnem:
Horn – F. Sørensen, Maroh, Heintz, Hector – Lehmann (C) – Risse, Gerhardt (85. Osako), Bittencourt, Mladenović (71. Hosiner) – Modeste.
Subs: Mesenhöler – Mavraj, Jojić, Hosiner, Olkowski, Osako, Vogt.
Coach:
Schalke 04: Fährmann – Caiçara, Matip, Neustädter, Aogo – Geis (78. Kolašinac), Højbjerg – Schöpf (61. Sané), Meyer, Belhanda – Huntelaar (C) (74. Di Santo).
Subs: Giefer – Di Santo, Kehrer, Kolašinac, Riether, Sam, Sané.
Coach:
Subs: Mesenhöler – Mavraj, Jojić, Hosiner, Olkowski, Osako, Vogt.
Coach:
Schalke 04: Fährmann – Caiçara, Matip, Neustädter, Aogo – Geis (78. Kolašinac), Højbjerg – Schöpf (61. Sané), Meyer, Belhanda – Huntelaar (C) (74. Di Santo).
Subs: Giefer – Di Santo, Kehrer, Kolašinac, Riether, Sam, Sané.
Coach:
Referees:
Attendance:
Scorer is FRANCO DI SANTO. Assisted by Dennis Aogo.
Scorer is MAX MEYER. Assisted by Pierre-Emile Højbjerg.
Scorer from a penalty shot is KLAAS-JAN HUNTELAAR..