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| Aston Villa – Tottenham | 0:2 (end) |
| Rayo Vallecano – Eibar | 1:1 (end) | | | Levante – Valencia | 1:0 (end) | | | Sevilla – Villarreal | 4:2 (end) |
| Bilbao – Betis | 3:1 (end) | | | Las Palmas – Real | 1:2 (end) |
| Leverkusen – Hamburg | 1:0 (end) | | | Dortmund – Mohuč | 2:0 (end) |
| Utrecht – Den Haag | 2:2 (end) | | | Heracles – Cambuur | 3:1 (end) | | | Arnhem – Feyenoord | 0:2 (end) |
| Ajax – Nijmegen | 2:2 (end) |
| Anderlecht – Kortrijk | 3:0 (end) | | | Genk – Oostende | 4:1 (end) | | | Mechelen – Standard | 4:0 (end) |
| Waregem – Mouscron | 3:0 (end) | | | Charleroi – Gent | 1:1 (end) | | | Leuven – Club Bruggy | 0:1 (end) |
| Westerlo – Waasland-Beveren | 1:0 (end) | | | Sint-Truiden – Lokeren | 1:1 (end) |
| Moreirense – Coimbra | 2:2 (end) | | | Arouca – Setúbal | 1:0 (end) | | | Nacional – Rio Ave | 1:0 (end) |
| Guimarães – FC Ferreira | 0:1 (end) | | | Belenenses – Braga | 3:0 (end) |
| Sturm Graz – Austria | 1:1 (end) |
| Saransk – FK Krasnodar | 0:1 (end) | | | Lok. Moskva – Ufa | 2:0 (end) | | | FC Zenit – Kazaň | 4:2 (end) |
| Olomouc – Sparta | 0:2 (end) |
| Michalovce – Trenčín | 1:3 (end) |
| Arsenal – Watford | 1:2 (end) | | | Man Utd. – West Ham | 1:1 (end) |
final
Sevilla FC
4:2
(1:2)
Villarreal CF
Goals:
23. Iborra (Gameiro), 52. V. Ruiz (own), 65. Konopljanka, 90+1. J. A. Reyes – 29. Bakambu, 37. Bakambu (Adrián López)
Ball possession: 55 % : 45 %.
Shots on target: 4:6. Shots off target: 9:3. Corners: 5:8. Offsides: 6:5. Fouls: 10:0.
Referees: Velasco – Alonso, Álvarez
Attendance:
Cards: 7. Banega (SEV), 73. Krohn-Dehli (SEV) – 25. Bonera (VLR) 80. Banega (SEV)
Penalty missed:
Ball possession: 55 % : 45 %.
Shots on target: 4:6. Shots off target: 9:3. Corners: 5:8. Offsides: 6:5. Fouls: 10:0.
Sevilla FC:
S. Rico – Mariano, Rami, Carriço, Trémoulinas – Iborra (74. Escudero), N'Zonzi (17. Cristóforo) – Krohn-Dehli, Banega, Konopljanka (71. J. A. Reyes) – Gameiro.
Subs: Soria – Cristóforo, Escudero, F. Llorente, Muñoz, J. A. Reyes.
Coach:
Villarreal CF: Aréola – M. Gaspar, Bonera, V. Ruiz, Bailly (46. Castillejo) – Antonio Rukavina, Pina, B. Soriano, Denis Suárez – Bakambu, Adrián López (71. Baptistão).
Subs: Asenjo – Baptistão, Castillejo, Hernández Cascante, Leiva, Marín, Trigueros.
Coach:
Subs: Soria – Cristóforo, Escudero, F. Llorente, Muñoz, J. A. Reyes.
Coach:
Villarreal CF: Aréola – M. Gaspar, Bonera, V. Ruiz, Bailly (46. Castillejo) – Antonio Rukavina, Pina, B. Soriano, Denis Suárez – Bakambu, Adrián López (71. Baptistão).
Subs: Asenjo – Baptistão, Castillejo, Hernández Cascante, Leiva, Marín, Trigueros.
Coach:
Referees: Velasco – Alonso, Álvarez
Attendance:
Scorer is JOSÉ ANTONIO REYES.
Scorer is JEVHEN KONOPLJANKA.
Own goal scorer is VÍCTOR RUIZ.
Scorer is CÉDRIC BAKAMBU. Assisted by Adrián López.