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All times are CEST (UTC + 2)
| Man Utd. – Manchester City | 1:2 (end) | | | Bournemouth – West Brom | 1:0 (end) | | | Arsenal – Southampton | 2:1 (end) |
| Burnley – Hull City | 1:1 (end) | | | Middlesbrough – Crystal Palace | 1:2 (end) | | | Stoke – Tottenham | 0:4 (end) |
| West Ham – Watford | 2:4 (end) | | | Liverpool – Leicester | 4:1 (end) |
| Celta Vigo – Atlético | 0:4 (end) | | | Real – Osasuna | 5:2 (end) | | | Malaga – Villarreal | 0:2 (end) |
| Sevilla – Las Palmas | 2:1 (end) | | | Barcelona – Alavés | 1:2 (end) |
| Leverkusen – Hamburg | 3:1 (end) | | | Wolfsburg – Kolín nad Rýnem | 0:0 (end) | | | Ingolstadt – Hertha | 0:2 (end) |
| Darmstadt – Frankfurt | 1:0 (end) | | | Freiburg – Mönchengladbach | 3:1 (end) | | | RB Leipzig – Dortmund | 1:0 (end) |
| Alkmaar – Willem II | 2:0 (end) | | | Zwolle – Utrecht | 1:1 (end) | | | Nijmegen – Eindhoven | 0:4 (end) |
| Heerenveen – Twente | 3:1 (end) | | | Excelsior – Heracles | 3:1 (end) |
| Eupen – Oostende | 2:1 (end) | | | Kortrijk – Westerlo | 4:1 (end) | | | Mechelen – Sint-Truiden | 2:0 (end) |
| Mouscron – Waregem | 1:5 (end) |
| Belenenses – Nacional | 2:1 (end) | | | Sporting – Moreirense | 3:0 (end) | | | Porto – Guimarães | 3:0 (end) |
| Sturm Graz – Rapid | 1:1 (end) | | | Austria – Wolfsberger | 4:1 (end) | | | Rheindorf Altach – Mattersburg | 2:1 (end) |
| St. Pölten – Ried | 2:3 (end) |
| Perm – Tomsk | 1:0 (end) | | | Orenburg – Machačkala | 0:0 (end) | | | CSKA Moskva – Grozny | 3:0 (end) |
| Sparta – Mladá Boleslav | 2:2 (end) | | | Hr. Králové – Příbram | 2:0 (end) | | | Karviná – Jihlava | 3:0 (end) |
| Liberec – Plzeň | 1:2 (end) |
| Trenčín – Trnava | 3:3 (end) | | | Slovan Bratislava – Myjava | 1:2 (end) | | | Michalovce – Žilina | 0:2 (end) |
| Senica – Ružomberok | 1:1 (end) |
final
Arsenal FC
2:1
(1:1)
Southampton FC
Goals:
29. Koscielny, 90+5. Cazorla (pen.) – 18. Čech (own)
Ball possession: 57 % : 43 %.
Shots on target: 2:5. Shots off target: 7:4. Corners: 6:1. Offsides: 0:2.
Referees: R. Madley – M. Perry, E. Smart (S. Hooper)
Attendance:
Cards: 16. Monreal (ARS), 26. Cazorla (ARS) – 54. Forster (SOT), 86. Højbjerg (SOT), 90. Fonte (SOT), 90+3. van Dijk (SOT), 90+4. Bertrand (SOT)
Penalty missed:
Ball possession: 57 % : 43 %.
Shots on target: 2:5. Shots off target: 7:4. Corners: 6:1. Offsides: 0:2.
Arsenal FC:
Čech – Bellerín, Mustafi, Koscielny (C), Monreal – Cazorla, Coquelin – Walcott (75. Iwobi), Özil, Oxlade-Chamberlain (62. Alexis Sánchez) – Lucas (62. Giroud).
Subs: Ospina – Holding, Elneny, Xhaka, Iwobi, Alexis Sánchez, Giroud.
Coach:
Southampton FC: Forster – Soares, Fonte (C), van Dijk, Bertrand – Clasie (64. Højbjerg), S. Davis, Romeu – Tadić (80. Ward-Prowse), Jay Rodriguez (46. S. Long), Redmond.
Subs: A. McCarthy – Jošida, Targett, Højbjerg, Ward-Prowse, Austin, S. Long.
Coach:
Subs: Ospina – Holding, Elneny, Xhaka, Iwobi, Alexis Sánchez, Giroud.
Coach:
Southampton FC: Forster – Soares, Fonte (C), van Dijk, Bertrand – Clasie (64. Højbjerg), S. Davis, Romeu – Tadić (80. Ward-Prowse), Jay Rodriguez (46. S. Long), Redmond.
Subs: A. McCarthy – Jošida, Targett, Højbjerg, Ward-Prowse, Austin, S. Long.
Coach:
Referees: R. Madley – M. Perry, E. Smart (S. Hooper)
Attendance:
Arsenal FC substitution: Lucas is replaced by Olivier Giroud.