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All times are CEST (UTC + 2)
| Watford – Man Utd. | 3:1 (end) | | | Crystal Palace – Stoke | 4:1 (end) | | | Southampton – Swansea | 1:0 (end) |
| Tottenham – Sunderland | 1:0 (end) |
| Osasuna – Celta Vigo | 0:0 (end) | | | Bilbao – Valencia | 2:1 (end) | | | Villarreal – Real Sociedad | 2:1 (end) |
| Espanyol – Real | 0:2 (end) |
| Augsburg – Mohuč | 1:3 (end) | | | Hertha – Schalke | 2:0 (end) |
| Sparta Rotterdam – Nijmegen | 2:0 (end) | | | Zwolle – Alkmaar | 0:2 (end) | | | Eindhoven – Feyenoord | 0:1 (end) |
| Heracles – Ajax | 0:2 (end) |
| Genk – Anderlecht | 0:2 (end) | | | Lokeren – Standard | 0:1 (end) | | | Oostende – Gent | 1:0 (end) |
| Arouca – Chaves | 0:1 (end) | | | Boavista – Feirense | 1:2 (end) | | | Tondela – Porto | 0:0 (end) |
| Rio Ave – Sporting | 3:1 (end) |
| Salzburg – Austria | 4:1 (end) | | | Rapid – Mattersburg | 3:0 (end) |
| Samara – CSKA Moskva | 1:2 (end) | | | FK Krasnodar – Rostov | 2:1 (end) |
| Plzeň – Karviná | 2:0 (end) |
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43
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John Guidetti (Real Club Celta de Vigo) is shown a yellow card.
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37
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Fran Mérida (CA Osasuna) is shown a yellow card.
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32
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David García (CA Osasuna) is shown a yellow card.
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27
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Oier (CA Osasuna) is shown a yellow card.
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Goals:
Ball possession: 39 % : 61 %.
Shots on target: 2:4. Shots off target: 4:6. Corners: 3:5. Offsides: 0:7. Fouls: 18:13.
Referees: Trujillo – Álvarez, Escuela
Attendance:
Cards: 27. Oier (OSS), 32. D. García (OSS), 37. Mérida (OSS) – 43. Guidetti (CVG)
Penalty missed:
Ball possession: 39 % : 61 %.
Shots on target: 2:4. Shots off target: 4:6. Corners: 3:5. Offsides: 0:7. Fouls: 18:13.
CA Osasuna:
Fernández – Buñuel, U. García, Oier (C), D. García, C. Clerc – Mérida (62. R. Torres), García, de las Cuevas – O. Riera (86. León), Rivière (51. Romero).
Subs: N. Pérez – León, R. Torres, Berenguer, Fuentes, Romero, Olavide.
Coach:
Celta de Vigo: S. Álvarez – Mallo (C), Cabral, Roncaglia, J. Castro – Wass (86. Radoja), P. Hernández – Señé (77. Sisto), Aspas, Bongonda – Guidetti (62. Rossi).
Subs: Villar – Radoja, Sisto, Lemos, Naranjo, Sergi Gómez, Rossi.
Coach:
Subs: N. Pérez – León, R. Torres, Berenguer, Fuentes, Romero, Olavide.
Coach:
Celta de Vigo: S. Álvarez – Mallo (C), Cabral, Roncaglia, J. Castro – Wass (86. Radoja), P. Hernández – Señé (77. Sisto), Aspas, Bongonda – Guidetti (62. Rossi).
Subs: Villar – Radoja, Sisto, Lemos, Naranjo, Sergi Gómez, Rossi.
Coach:
Referees: Trujillo – Álvarez, Escuela
Attendance: