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All times are CEST (UTC + 2)
| West Ham – Southampton | 0:3 (end) |
| Leganés – Valencia | 1:2 (end) | | | Atlético – La Coruňa | 1:0 (end) | | | Villarreal – Osasuna | 3:1 (end) |
| Espanyol – Celta Vigo | 0:2 (end) |
| Hoffenheim – Schalke | 2:1 (end) | | | Kolín nad Rýnem – RB Leipzig | 1:1 (end) |
| Nijmegen – Willem II | 0:0 (end) | | | Utrecht – Sparta Rotterdam | 2:0 (end) | | | Twente – Arnhem | 2:1 (end) |
| Feyenoord – Kerkrade | 5:0 (end) |
| Standard – Eupen | 3:0 (end) | | | Kortrijk – Genk | 4:1 (end) | | | Anderlecht – Westerlo | 1:2 (end) |
| Braga – Setúbal | 2:1 (end) | | | Marítimo – Tondela | 2:0 (end) | | | FC Ferreira – Rio Ave | 2:1 (end) |
| Moreirense – Guimarães | 0:1 (end) |
| Rheindorf Altach – Salzburg | 0:0 (end) |
| Orenburg – Ural | 0:1 (end) | | | Arsenal Tula – Grozny | 0:0 (end) | | | Spartak – Ufa | 0:1 (end) |
| Machačkala – FC Zenit | 2:2 (end) |
| Sparta – Slavia | 0:2 (end) |
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86
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1. FC Köln substitution: Anthony Modeste is replaced by Sehrou Guirassy.
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83
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1. FC Köln substitution: Konstantin Rausch is replaced by Filip Mladenović.
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82
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RasenBallsport Leipzig substitution: Oliver Burke is replaced by Timo Werner.
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72
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1. FC Köln substitution: Juja Osako is replaced by Artjoms Rudņevs.
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63
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RasenBallsport Leipzig substitution: Davie Selke is replaced by Yussuf Poulsen.
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46
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RasenBallsport Leipzig substitution: Benno Schmitz is replaced by Bernardo.
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Goals:
25. Osako (Rausch) – 5. Burke (Sabitzer)
Ball possession: 47 % : 53 %.
Shots on target: 2:2. Shots off target: 6:6. Corners: 1:6. Offsides: 3:0. Fouls: 10:15.
Referees:
Attendance:
Cards: 54. Osako (KLN) – 40. Orban (RBL), 90+2. Bernardo (RBL)
Penalty missed:
Ball possession: 47 % : 53 %.
Shots on target: 2:2. Shots off target: 6:6. Corners: 1:6. Offsides: 3:0. Fouls: 10:15.
1. FC Kolín nad Rýnem:
Horn – F. Sørensen, Mavraj, Heintz, Rausch (83. Mladenović) – Risse, Hector, Lehmann, Zoller – Modeste (86. Guirassy), Osako (72. Rudņevs).
Subs: Müller – Rudņevs, S. Özcan, Olkowski, Mladenović, Jojić, Guirassy.
Coach:
RB Leipzig: Gulácsi – Schmitz (46. Bernardo), Orban, Compper, Halstenberg – Ilsanker, Keïta – Burke (82. Werner), Kaiser, Sabitzer – Selke (63. Y. Poulsen).
Subs: Müller – Demme, Bernardo, R. Khedira, Kalmár, Werner, Y. Poulsen.
Coach:
Subs: Müller – Rudņevs, S. Özcan, Olkowski, Mladenović, Jojić, Guirassy.
Coach:
RB Leipzig: Gulácsi – Schmitz (46. Bernardo), Orban, Compper, Halstenberg – Ilsanker, Keïta – Burke (82. Werner), Kaiser, Sabitzer – Selke (63. Y. Poulsen).
Subs: Müller – Demme, Bernardo, R. Khedira, Kalmár, Werner, Y. Poulsen.
Coach:
Referees:
Attendance: