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All times are CEST (UTC + 2)
| Man Utd. – Stoke | 1:1 (end) | | | Leicester – Southampton | 0:0 (end) | | | Tottenham – Manchester City | 2:0 (end) |
| Burnley – Arsenal | 0:1 (end) |
| Valencia – Atlético | 0:2 (end) | | | Real – Eibar | 1:1 (end) | | | Espanyol – Villarreal | 0:0 (end) |
| Malaga – Bilbao | 2:1 (end) | | | Celta Vigo – Barcelona | 4:3 (end) |
| Wolfsburg – Mohuč | 0:0 (end) | | | Schalke – Mönchengladbach | 4:0 (end) |
| Ajax – Utrecht | 3:2 (end) | | | Willem II – Feyenoord | 0:2 (end) | | | Heracles – Twente | 1:1 (end) |
| Sparta Rotterdam – Alkmaar | 1:1 (end) |
| Club Bruggy – Gent | 1:0 (end) | | | Standard – Anderlecht | 0:1 (end) | | | Genk – Mechelen | 2:1 (end) |
| SL Benfica – Feirense | 4:0 (end) | | | Setúbal – Marítimo | 0:1 (end) | | | Boavista – Moreirense | 2:0 (end) |
| Arouca – Braga | 1:1 (end) |
| Salzburg – Sturm Graz | 0:1 (end) | | | Ried – Rapid | 4:2 (end) | | | Austria – St. Pölten | 2:1 (end) |
| Ufa – Perm | 1:1 (end) | | | FC Zenit – Spartak | 4:2 (end) | | | Rostov – CSKA Moskva | 2:0 (end) |
| FK Krasnodar – Kazaň | 1:0 (end) |
| Brno – Sparta | 3:3 (end) | | | Liberec – Teplice | 2:0 (end) | | | Plzeň – Hradec Králové | 4:1 (end) |
Goals:
42. Armenteros – 40. Klich
Ball possession: 48 % : 52 %.
Shots on target: 6:3. Shots off target: 8:3. Corners: 2:6. Offsides: 2:1. Fouls: 13:16.
Referees:
Attendance:
Cards: 31. Breukers (HRC), 45. Pelupessy (HRC) – 28. Ünal (TWE), 37. Celina (TWE), 64. Klich (TWE), 90+1. Bijen (TWE)
Penalty missed:
Ball possession: 48 % : 52 %.
Shots on target: 6:3. Shots off target: 8:3. Corners: 2:6. Offsides: 2:1. Fouls: 13:16.
Heracles Almelo:
B. Castro – te Wierik, R. Pröpper, Hoogma, Breukers – Bruns, Pelupessy, L. Duarte (77. van Ooijen) – Navrátil (59. Darri), Armenteros (87. Vermeij), Kuwas.
Subs: Brouwer, Fij – Droste, Darri, Kada, van Mieghem, van Ooijen, Vermeij, Vujičević.
Coach:
Twente Enschede: Marsman – ter Avest, Bijen, Thesker, Trajkovski – Klich, Ede (70. Seys), Mokotjo – Celina (59. Jensen), Ünal, Yeboah (86. Oosterwijk).
Subs: Drommel, Stevens – Ebecilio, George, Hölscher, Katsikas, Jensen, Oosterwijk, van der Heyden, van der Lely, Seys.
Coach:
Subs: Brouwer, Fij – Droste, Darri, Kada, van Mieghem, van Ooijen, Vermeij, Vujičević.
Coach:
Twente Enschede: Marsman – ter Avest, Bijen, Thesker, Trajkovski – Klich, Ede (70. Seys), Mokotjo – Celina (59. Jensen), Ünal, Yeboah (86. Oosterwijk).
Subs: Drommel, Stevens – Ebecilio, George, Hölscher, Katsikas, Jensen, Oosterwijk, van der Heyden, van der Lely, Seys.
Coach:
Referees:
Attendance:
Heracles Almelo substitution: Jaroslav Navrátil is replaced by Brahim Darri.