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All times are CEST (UTC + 2)
| Man Utd. – Arsenal | 1:1 (end) | | | Crystal Palace – Manchester City | 1:2 (end) | | | Everton – Swansea | 1:1 (end) |
| Southampton – Liverpool | 0:0 (end) | | | Stoke – Bournemouth | 0:1 (end) | | | Sunderland – Hull City | 3:0 (end) |
| Watford – Leicester | 2:1 (end) | | | Tottenham – West Ham | 3:2 (end) |
| La Coruňa – Sevilla | 2:3 (end) | | | Barcelona – Malaga | 0:0 (end) | | | Eibar – Celta Vigo | 1:0 (end) |
| Atlético – Real | 0:3 (end) |
| Mönchengladbach – Kolín nad Rýnem | 1:2 (end) | | | Mohuč – Freiburg | 4:2 (end) | | | Wolfsburg – Schalke | 0:1 (end) |
| Augsburg – Hertha | 0:0 (end) | | | Darmstadt – Ingolstadt | 0:1 (end) | | | Dortmund – Bayern | 1:0 (end) |
| Heerenveen – Arnhem | 1:1 (end) | | | Heracles – GA Eagles | 2:1 (end) | | | Willem II – Eindhoven | 0:0 (end) |
| Excelsior – Sparta Rotterdam | 3:2 (end) | | | Groningen – Den Haag | 2:1 (end) |
| Genk – Eupen | 2:0 (end) | | | Oostende – Westerlo | 5:0 (end) | | | Waasland-Beveren – Kortrijk | 1:1 (end) |
| Mouscron – Gent | 0:2 (end) |
| Rheindorf Altach – Sturm Graz | 1:1 (end) | | | Austria – Ried | 2:0 (end) | | | Admira – Wolfsberger | 4:1 (end) |
| St. Pölten – Mattersburg | 2:2 (end) |
| Orenburg – Lok. Moskva | 1:1 (end) | | | Machačkala – Ufa | 0:1 (end) |
| Mladá Boleslav – Plzeň | 0:0 (end) | | | Brno – Příbram | 2:2 (end) | | | Bohemians 1905 – Teplice | 0:1 (end) |
| Slovácko – Hr. Králové | 1:3 (end) | | | Jablonec – Liberec | 3:0 (end) |
| Michalovce – Podbrezová | 1:3 (end) | | | Senica – Zlaté Moravce | 1:3 (end) | | | Dunajská Streda – Trenčín | 2:0 (end) |
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88
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SBV Vitesse Arnhem substitution: Navarone Foor is replaced by Milot Rashica.
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87
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SC Heerenveen substitution: Younes Namli is replaced by Simon Thern.
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78
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SC Heerenveen substitution: Reza Ghoochanneijhad is replaced by Henk Veerman.
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78
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SC Heerenveen substitution: Morten Thorsby is replaced by Pelle van Amersfoort.
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35
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SBV Vitesse Arnhem substitution: Nathan is replaced by Adnane Tighadouini.
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Goals:
84. Veerman – 73. L. Baker
Ball possession: 55 % : 45 %.
Shots on target: 3:2. Shots off target: 5:8. Corners: 1:6. Offsides: 0:4. Fouls: 8:12.
Referees:
Attendance:
Cards: 61. Thorsby (HEE), 74. Mulder (HEE) – 57. Nakamba (ARN)
Penalty missed:
Ball possession: 55 % : 45 %.
Shots on target: 3:2. Shots off target: 5:8. Corners: 1:6. Offsides: 0:4. Fouls: 8:12.
SC Heerenveen:
Mulder – Marzo, St. Juste, van Aken, Bijker – Thorsby (78. van Amersfoort), Namli (87. Thern), Kobajaši – Zeneli, Ghoochanneijhad (78. Veerman), Sam Larsson.
Subs: Bekkema, van der Steen – Facey, van Amersfoort, Cavlan, Huizing, Thern, Veerman, Vlap, Slagveer.
Coach:
SBV Vitesse Arnhem: Room – Leerdam, Kašia, Kruiswijk, Ota – L. Baker, Yeini, Nakamba – Foor (88. Rashica), van Wolfswinkel, Nathan (35. Tighadouini).
Subs: Houwen – Lelieveld, Tighadouini, Dauda, Rashica, van Bergen, Korjan, Faye, M. Osman, Miazga.
Coach:
Subs: Bekkema, van der Steen – Facey, van Amersfoort, Cavlan, Huizing, Thern, Veerman, Vlap, Slagveer.
Coach:
SBV Vitesse Arnhem: Room – Leerdam, Kašia, Kruiswijk, Ota – L. Baker, Yeini, Nakamba – Foor (88. Rashica), van Wolfswinkel, Nathan (35. Tighadouini).
Subs: Houwen – Lelieveld, Tighadouini, Dauda, Rashica, van Bergen, Korjan, Faye, M. Osman, Miazga.
Coach:
Referees:
Attendance: