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All times are CEST (UTC + 2)
| Bournemouth – West Ham | 3:2 (end) | | | Everton – West Brom | 3:0 (end) | | | Hull City – Swansea | 2:1 (end) |
| Valencia – Gijón | 1:1 (end) | | | Sevilla – Leganés | 1:1 (end) | | | Malaga – Alavés | 1:2 (end) |
| Granada – Atlético | 0:1 (end) |
| Bayern – Frankfurt | 3:0 (end) | | | Hertha – Dortmund | 2:1 (end) | | | Darmstadt – Mohuč | 2:1 (end) |
| Freiburg – Hoffenheim | 1:1 (end) | | | RB Leipzig – Wolfsburg | 0:1 (end) | | | Ingolstadt – Kolín nad Rýnem | 2:2 (end) |
| Den Haag – Nijmegen | 1:0 (end) | | | GA Eagles – Eindhoven | 1:3 (end) | | | Heracles – Utrecht | 2:1 (end) |
| Excelsior – Heerenveen | 4:1 (end) |
| Setúbal – Feirense | 1:2 (end) | | | Chaves – Braga | 0:0 (end) | | | Tondela – Sporting | 1:4 (end) |
| St. Pölten – Ried | 1:0 (end) | | | Austria – Wolfsberger | 3:0 (end) | | | Admira – Salzburg | 1:1 (end) |
| Rheindorf Altach – Mattersburg | 3:0 (end) |
| Ufa – Samara | 1:0 (end) | | | CSKA Moskva – Tomsk | 4:0 (end) | | | Kazaň – Orenburg | 0:0 (end) |
| Příbram – Hr. Králové | 1:0 (end) | | | Zlín – Slovácko | 1:1 (end) | | | Jihlava – Karviná | 2:4 (end) |
| Dukla Praha – Jablonec | 1:0 (end) | | | Brno – Bohemians 1905 | 0:0 (end) | | | Plzeň – Liberec | 1:0 (end) |
| Dunajská Streda – Žilina | 2:2 (end) | | | Senica – Slovan Bratislava | 0:1 (end) |
| Middlesbrough – Manchester City | 0:2 (end) |
Goals:
43. Jovetić (F. Vázquez) – 3. Gabriel (El Zhar)
Referees: González – Sánchez, Martínez
Attendance:
Cards: 57. Sarabia (SEV), 75. Kranevitter (SEV) – 61. Gabriel (LGS), 67. Mantovani (LGS), 89. R. Pérez (LGS)
Penalty missed:
Sevilla FC:
S. Rico – Rami, Carriço, Lenglet (46. N'Zonzi) – Kranevitter – Mariano, F. Vázquez (69. Iborra), Sarabia – W. Montoya (46. Vietto), Jovetić, Correa.
Subs: Soria – Iborra, Vietto, Ben Yedder, N'Zonzi, Escudero, Ganso.
Coach:
CD Leganés: Herrerín – Bustinza, Mantovani (C), Siovas, Tito – Morán, R. Pérez – El Zhar, Gabriel (90. Insua), Szymanowski (63. Machís) – Guerrero (68. Luciano).
Subs: Champagne – Machís, Díaz, Insua, Unai López, Samu García, Luciano.
Coach:
Subs: Soria – Iborra, Vietto, Ben Yedder, N'Zonzi, Escudero, Ganso.
Coach:
CD Leganés: Herrerín – Bustinza, Mantovani (C), Siovas, Tito – Morán, R. Pérez – El Zhar, Gabriel (90. Insua), Szymanowski (63. Machís) – Guerrero (68. Luciano).
Subs: Champagne – Machís, Díaz, Insua, Unai López, Samu García, Luciano.
Coach:
Referees: González – Sánchez, Martínez
Attendance:
Scorer is STEVAN JOVETIĆ. Assisted by Franco Vázquez.