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All times are CEST (UTC + 2)
| Bournemouth – Middlesbrough | 4:0 (end) | | | Hull City – Watford | 2:0 (end) | | | Swansea – Stoke | 2:0 (end) |
| West Ham – Everton | 0:0 (end) |
| Malaga – Valencia | 2:0 (end) | | | Villarreal – Leganés | 2:1 (end) | | | Osasuna – Gijón | 2:2 (end) |
| Espanyol – Atlético | 0:1 (end) |
| Bayern – Mohuč | 2:2 (end) | | | Hertha – Wolfsburg | 1:0 (end) | | | Hamburg – Darmstadt | 1:2 (end) |
| Ingolstadt – Bremen | 2:4 (end) | | | Frankfurt – Augsburg | 3:1 (end) | | | Mönchengladbach – Dortmund | 2:3 (end) |
| Nijmegen – Excelsior | 0:1 (end) | | | Zwolle – Heracles | 1:2 (end) | | | Alkmaar – Twente | 2:1 (end) |
| GA Eagles – Groningen | 2:3 (end) |
| Charleroi – Waregem | 2:0 (end) | | | Kortrijk – Eupen | 3:3 (end) | | | Lierse – Waasland-Beveren | 2:3 (end) |
| Lokeren – Roeselare | 2:1 (end) | | | Sint-Truiden – Saint-Gilloise | 0:1 (end) | | | Mechelen – Standard | 1:0 (end) |
| Marítimo – Belenenses | 3:0 (end) | | | Tondela – Nacional | 2:0 (end) | | | Estoril – Setúbal | 3:0 (end) |
| Sporting – SL Benfica | 1:1 (end) |
| Sturm Graz – Mattersburg | 0:2 (end) | | | Ried – Wolfsberger | 1:1 (end) | | | Rheindorf Altach – Admira | 0:0 (end) |
| St. Pölten – Salzburg | 1:2 (end) |
| FC Zenit – Ural | 2:0 (end) | | | Rostov – Spartak | 3:0 (end) | | | Lok. Moskva – Perm | 3:3 (end) |
| Grozny – Machačkala | 0:1 (end) |
| Brno – Mladá Boleslav | 2:3 (end) | | | Hradec Králové – Liberec | 0:1 (end) | | | Teplice – Karviná | 1:0 (end) |
| Bohemians 1905 – Zlín | 0:2 (end) |
| Trenčín – Ružomberok | 2:1 (end) | | | Michalovce – Dunajská Streda | 1:2 (end) |
| Chelsea – Tottenham | 4:2 (end) |
Goals:
36. Recio (Ontiveros), 40. Sandro Ramírez (Ricca)
Referees:
Attendance:
Cards: 13. Recio (MLG), 45+3. D. Llorente (MLG), 70. J. P. Carlos (MLG) – 39. Mangala (VAL), 62. Parejo (VAL), 70. E. Pérez (VAL)
Penalty missed:
Malaga CF:
Kameni – Rosales, D. Llorente, L. Hernández, Ricca – Camacho, Recio – Ontiveros (72. Keko), Fornals, Jony (59. J. P. Carlos) – Sandro Ramírez.
Subs: Bojko – Demichelis, J. P. Carlos, Charles, G. Castro, Keko, José Rodríguez.
Coach:
Valencia CF: Diego Alves – Cancelo, Garay (45. Orellana), Mangala, Latorre – Parejo, E. Pérez – Munir (72. Nani), Medrán (76. Zaza), Soler – S. Mina.
Subs: Doménech – Santos, Siqueira, Zaza, Montoya, Nani, Orellana.
Coach:
Subs: Bojko – Demichelis, J. P. Carlos, Charles, G. Castro, Keko, José Rodríguez.
Coach:
Valencia CF: Diego Alves – Cancelo, Garay (45. Orellana), Mangala, Latorre – Parejo, E. Pérez – Munir (72. Nani), Medrán (76. Zaza), Soler – S. Mina.
Subs: Doménech – Santos, Siqueira, Zaza, Montoya, Nani, Orellana.
Coach:
Referees:
Attendance:
Scorer is SANDRO RAMÍREZ. Assisted by Federico Ricca.
Scorer is RECIO. Assisted by Javier Ontiveros.