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All times are CEST (UTC + 2)
| Gijón – Betis | 2:2 (end) | | | Leganés – Alavés | 1:1 (end) | | | La Coruňa – Las Palmas | 3:0 (end) |
| Sevilla – Osasuna | 5:0 (end) |
| Bayern – Freiburg | 4:1 (end) | | | Dortmund – Bremen | 4:3 (end) | | | Mönchengladbach – Darmstadt | 2:2 (end) |
| Hertha – Leverkusen | 2:6 (end) | | | Kolín nad Rýnem – Mohuč | 2:0 (end) | | | Hamburg – Wolfsburg | 2:1 (end) |
| Ingolstadt – Schalke | 1:1 (end) | | | Hoffenheim – Augsburg | 0:0 (end) | | | Frankfurt – RB Leipzig | 2:2 (end) |
| Utrecht – Heerenveen | 2:1 (end) | | | Alkmaar – Groningen | 4:1 (end) |
| Roeselare – Eupen | 3:2 (end) | | | Lokeren – Genk | 1:1 (end) | | | Mouscron – Kortrijk | 0:1 (end) |
| Rio Ave – Belenenses | 2:0 (end) | | | FC Ferreira – Marítimo | 0:0 (end) | | | Nacional – Setúbal | 1:2 (end) |
| Guimarães – Feirense | 0:1 (end) | | | Boavista – SL Benfica | 2:2 (end) |
| Ried – St. Pölten | 1:1 (end) | | | Salzburg – Admira | 2:0 (end) | | | Wolfsberger – Austria | 2:1 (end) |
| Mattersburg – Rheindorf Altach | 1:0 (end) |
| Jihlava – Příbram | 1:1 (end) | | | Mladá Boleslav – Slavia | 1:2 (end) | | | Brno – Plzeň | 0:1 (end) |
| Dukla Praha – Zlín | 1:0 (end) | | | Jablonec – Teplice | 0:0 (end) | | | Bohemians 1905 – Karviná | 2:0 (end) |
| Sparta – Hr. Králové | 3:2 (end) | | | Slovácko – Liberec | 0:1 (end) |
Goals:
71. Weiser (Kalou), 86. Allagui (pen.) – 5. J. Hernández, 31. Havertz (J. Hernández), 45+1. Havertz (Brandt), 64. Kießling (pen.), 81. Aránguiz (pen.), 90. Pohjanpalo (D. da Costa)
Referees:
Attendance:
Cards: 12. Allan (HER), 36. Ibišević (HER), 63. Darida (HER) – 41. Henrichs (LEV), 60. Wendell (LEV)
Penalty missed:
Hertha BSC:
Almenning Jarstein – Pekarík, Brooks (46. Langkamp), Torunarigha, Plattenhardt – Weiser, Darida, Allan (46. Skjelbred), Esswein (69. Allagui) – Ibišević, Kalou.
Subs: Kraft – Skjelbred, Stark, Allagui, Duda, Langkamp, Haraguči.
Coach:
Bayer 04 Leverkusen: Leno – Henrichs, Tah, Jedvaj, Wendell (71. D. da Costa) – Havertz, Baumgartlinger, Aránguiz, Brandt – J. Hernández (79. Bailey), Kießling (73. Pohjanpalo).
Subs: R. Özcan – Dragović, Bailey, Mehmedi, Pohjanpalo, V. Jurčenko, D. da Costa.
Coach:
Subs: Kraft – Skjelbred, Stark, Allagui, Duda, Langkamp, Haraguči.
Coach:
Bayer 04 Leverkusen: Leno – Henrichs, Tah, Jedvaj, Wendell (71. D. da Costa) – Havertz, Baumgartlinger, Aránguiz, Brandt – J. Hernández (79. Bailey), Kießling (73. Pohjanpalo).
Subs: R. Özcan – Dragović, Bailey, Mehmedi, Pohjanpalo, V. Jurčenko, D. da Costa.
Coach:
Referees:
Attendance:
Scorer is JOEL POHJANPALO. Assisted by Danny da Costa.
Scorer from a penalty shot is SAMI ALLAGUI..
Scorer from a penalty shot is CHARLES ARÁNGUIZ..
Scorer is MITCHELL WEISER. Assisted by Salomon Kalou.
Scorer from a penalty shot is STEFAN KIEßLING..