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All times are CEST (UTC + 2)
| Swansea – Man Utd. | 0:4 (end) | | | Liverpool – Crystal Palace | 1:0 (end) | | | Southampton – West Ham | 3:2 (end) |
| Bournemouth – Watford | 0:2 (end) | | | Burnley – West Brom | 0:1 (end) | | | Stoke – Arsenal | 1:0 (end) |
| Valencia – Las Palmas | 1:0 (end) | | | Celta Vigo – Real Sociedad | 2:3 (end) | | | Girona – Atlético | 2:2 (end) |
| Sevilla – Espanyol | 1:1 (end) |
| Hoffenheim – Bremen | 1:0 (end) | | | Hertha – Stuttgart | 2:0 (end) | | | Hamburg – Augsburg | 1:0 (end) |
| Mohuč – Hannover | 0:1 (end) | | | Wolfsburg – Dortmund | 0:3 (end) | | | Schalke – RB Leipzig | 2:0 (end) |
| Twente – Venlo | 1:2 (end) | | | Alkmaar – Den Haag | 2:0 (end) | | | Heerenveen – Heracles | 1:1 (end) |
| Genk – Charleroi | 0:1 (end) | | | Eupen – Oostende | 2:1 (end) | | | Waasland-Beveren – Lokeren | 2:3 (end) |
| Mechelen – Antwerp | 1:2 (end) |
| Tondela – Estoril | 2:3 (end) | | | Guimarães – Sporting | 0:5 (end) | | | SL Benfica – Belenenses | 5:0 (end) |
| Rapid – Sturm Graz | 1:2 (end) | | | Wolfsberger – Admira | 2:0 (end) |
| Ural – CSKA Moskva | 0:0 (end) | | | Spartak – Lok. Moskva | 3:4 (end) | | | Kazaň – Machačkala | 6:0 (end) |
| Zlín – Karviná | 1:0 (end) | | | Ostrava – Teplice | 3:3 (end) | | | Bohemians 1905 – Slavia | 0:0 (end) |
| Mladá Boleslav – Liberec | 0:3 (end) |
| Trnava – Slovan Bratislava | 1:2 (end) | | | Trenčín – Michalovce | 1:2 (end) |
final
Southampton FC
3:2
(2:1)
West Ham United
Goals:
11. Gabbiadini (Redmond), 38. Tadić (pen.), 90+3. Ch. Austin (pen.) – 45. J. Hernández, 74. J. Hernández
Ball possession: 66 % : 34 %.
Shots on target: 5:8. Shots off target: 6:6. Corners: 7:2. Offsides: 1:0. Fouls: 18:10.
Referees: Lee Mason – Constantine Hatzidakis, Matt Wilkes
Attendance: 31 424
Cards: 15. Tadić (SOT) – 90+1. Zabaleta (WHU) 33. Arnautović (WHU)
Penalty missed:
Ball possession: 66 % : 34 %.
Shots on target: 5:8. Shots off target: 6:6. Corners: 7:2. Offsides: 1:0. Fouls: 18:10.
Southampton FC:
Forster – Soares, Stephens, Jošida, Bertrand – Lemina (65. Ward-Prowse), Romeu – S. Davis (C) (80. S. Long), Tadić, Redmond – Gabbiadini (80. Ch. Austin).
Subs: A. McCarthy – Bednarek, McQueen, Ward-Prowse, Boufal, S. Long, Ch. Austin.
Coach:
West Ham United: Hart – Zabaleta, Ogbonna, Fonte, Cresswell – Noble (C), Rice (76. Obiang) – Antonio (68. D. Sakho), A. Ayew (68. E. Fernandes), Arnautović – J. Hernández.
Subs: Adrián – Byram, Masuaku, Obiang, E. Fernandes, D. Sakho.
Coach:
Subs: A. McCarthy – Bednarek, McQueen, Ward-Prowse, Boufal, S. Long, Ch. Austin.
Coach:
West Ham United: Hart – Zabaleta, Ogbonna, Fonte, Cresswell – Noble (C), Rice (76. Obiang) – Antonio (68. D. Sakho), A. Ayew (68. E. Fernandes), Arnautović – J. Hernández.
Subs: Adrián – Byram, Masuaku, Obiang, E. Fernandes, D. Sakho.
Coach:
Referees: Lee Mason – Constantine Hatzidakis, Matt Wilkes
Attendance: 31 424
Southampton FC substitution: Steven Davis is replaced by Shane Long.
West Ham United substitution: André Ayew is replaced by Edimilson Fernandes.