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All times are CEST (UTC + 2)
| Crystal Palace – Stoke | 2:1 (end) | | | Newcastle – Watford | 0:3 (end) | | | Swansea – Bournemouth | 0:0 (end) |
| Tottenham – West Brom | 1:1 (end) | | | Liverpool – Chelsea | 1:1 (end) |
| Alavés – Eibar | 1:2 (end) | | | Real – Malaga | 3:2 (end) | | | Betis – Girona | 2:2 (end) |
| Levante – Atlético | 0:5 (end) |
| Dortmund – Schalke | 4:4 (end) | | | RB Leipzig – Bremen | 2:0 (end) | | | Freiburg – Mohuč | 2:1 (end) |
| Frankfurt – Leverkusen | 0:1 (end) | | | Augsburg – Wolfsburg | 2:1 (end) | | | Mönchengladbach – Bayern | 2:1 (end) |
| Venlo – Willem II | 3:3 (end) | | | Heracles – Breda | 2:1 (end) | | | Groningen – Feyenoord | 0:2 (end) |
| Heerenveen – Zwolle | 1:2 (end) |
| Antwerp – Mechelen | 0:0 (end) | | | Oostende – Eupen | 1:0 (end) | | | Sint-Truiden – Lokeren | 0:0 (end) |
| Waasland-Beveren – Charleroi | 0:2 (end) |
| Portimonense – Tondela | 2:0 (end) | | | Boavista – Moreirense | 1:0 (end) | | | Aves – Porto | 1:1 (end) |
| Sturm Graz – Linec | 1:0 (end) | | | Rheindorf Altach – St. Pölten | 3:0 (end) | | | Admira – Mattersburg | 2:0 (end) |
| Tosno – Arsenal Tula | 3:2 (end) | | | Grozny – Ufa | 2:1 (end) |
| Ostrava – Karviná | 2:1 (end) |
| Zlaté Moravce – Michalovce | 0:1 (end) | | | Trenčín – Ružomberok | 1:2 (end) | | | Podbrezová – Slovan Bratislava | 1:1 (end) |
| Trnava – Žilina | 0:3 (end) |
Goals:
5. Suárez Pier (Gameiro) (own), 29. Gameiro, 59. Gameiro (Griezmann), 65. Griezmann (Gameiro), 68. Griezmann (Gameiro)
Ball possession: 44 % : 56 %.
Shots on target: 2:11. Shots off target: 10:3. Corners: 2:3. Offsides: 0:5. Fouls: 11:14.
Referees: Trujillo – Escuela, Martín
Attendance: 21 540
Cards: 52. Chema (LVN), 54. Morales (LVN) – 90+2. Koke (ATM)
Penalty missed:
Ball possession: 44 % : 56 %.
Shots on target: 2:11. Shots off target: 10:3. Corners: 2:3. Offsides: 0:5. Fouls: 11:14.
Levante UD:
Olazábal – Moore, Chema, Suárez Pier, Toňo – Doukouré, Campaña (70. Nano) – Jason (52. López), E. Bardi, Morales (77. Samuel) – Ünal.
Subs: Fernández – López, Postigo, Nano, Cabaco, Pedro López, Samuel.
Coach:
Atlético Madrid: Oblak – Partey, Savić, Godín, Luís – Á. Correa (66. Ferreira-Carrasco), Gabi, Saúl Ñíguez (73. Augusto Fernández), Koke – Griezmann, Gameiro (70. F. Torres).
Subs: Moyà – F. Torres, Ferreira-Carrasco, Augusto Fernández, Vietto, Hernández, J. Giménez.
Coach:
Subs: Fernández – López, Postigo, Nano, Cabaco, Pedro López, Samuel.
Coach:
Atlético Madrid: Oblak – Partey, Savić, Godín, Luís – Á. Correa (66. Ferreira-Carrasco), Gabi, Saúl Ñíguez (73. Augusto Fernández), Koke – Griezmann, Gameiro (70. F. Torres).
Subs: Moyà – F. Torres, Ferreira-Carrasco, Augusto Fernández, Vietto, Hernández, J. Giménez.
Coach:
Referees: Trujillo – Escuela, Martín
Attendance: 21 540
Atlético Madrid substitution: Kévin Gameiro is replaced by Fernando Torres.