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All times are CEST (UTC + 2)
| Southampton – Chelsea | 2:3 (end) | | | Burnley – Leicester | 2:1 (end) | | | Huddersfield Town – Watford | 1:0 (end) |
| Swansea – Everton | 1:1 (end) | | | Liverpool – Bournemouth | 3:0 (end) | | | Tottenham – Manchester City | 1:3 (end) |
| Sevilla – Villarreal | 2:2 (end) | | | Barcelona – Valencia | 2:1 (end) | | | Las Palmas – Real Sociedad | 0:1 (end) |
| Leganés – Celta Vigo | 1:0 (end) | | | Bilbao – La Coruňa | 2:3 (end) |
| Hoffenheim – Hamburg | 2:0 (end) | | | Hertha – Kolín nad Rýnem | 2:1 (end) | | | Leverkusen – Frankfurt | 4:1 (end) |
| Stuttgart – Hannover | 1:1 (end) | | | Bayern – Mönchengladbach | 5:1 (end) |
| Den Haag – Twente | 2:1 (end) | | | Arnhem – Sparta Rotterdam | 7:0 (end) | | | Venlo – Heerenveen | 0:2 (end) |
| Zwolle – Excelsior | 1:1 (end) |
| Waregem – Mouscron | 5:1 (end) | | | Lierse – Kortrijk | 0:2 (end) | | | Lokeren – Eupen | 3:0 (end) |
| Waasland-Beveren – Leuven | 0:2 (end) | | | Standard – Gent | 1:0 (end) |
| Portimonense – Estoril | 0:1 (end) | | | Aves – Feirense | 1:0 (end) | | | Boavista – Chaves | 3:3 (end) |
| Guimarães – Setúbal | 1:1 (end) |
| Sturm Graz – Mattersburg | 3:0 (end) | | | Rheindorf Altach – Wolfsberger | 2:1 (end) | | | St. Pölten – Linz | 1:3 (end) |
| Perm – Kazaň | 0:3 (end) | | | Dynamo – Lok. Moskva | 0:4 (end) | | | FC Zenit – Machačkala | 1:0 (end) |
| FK Krasnodar – Arsenal Tula | 3:0 (end) |
| Jablonec – Olomouc | 0:0 (end) | | | Ostrava – Bohemians 1905 | 2:0 (end) | | | Slovácko – Brno | 1:0 (end) |
| Dukla Praha – Liberec | 2:0 (end) |
| Slovan Bratislava – Trenčín | 1:3 (end) | | | Dunajská Streda – Žilina | 3:1 (end) | | | Michalovce – Zlaté Moravce | 2:0 (end) |
| Podbrezová – Senica | 3:1 (end) |
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85
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Villarreal CF substitution: Carlos Bacca is replaced by Enes Ünal.
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85
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Sevilla FC substitution: Sandro Ramírez is replaced by Roque.
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78
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Villarreal CF substitution: Daniel Raba is replaced by Javi Fuego.
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67
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Sevilla FC substitution: Franco Vázquez is replaced by Nolito.
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65
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Villarreal CF substitution: Denis Čeryšev is replaced by Roberto Soriano.
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54
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Sevilla FC substitution: Luis Muriel is replaced by Wissam Ben Yedder.
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Goals:
78. Nolito (Lenglet), 82. N'Zonzi (Sandro Ramírez) – 36. Raba (Castillejo), 68. Bacca (Raba)
Ball possession: 58 % : 42 %.
Shots on target: 4:4. Shots off target: 9:0. Corners: 10:2. Offsides: 2:6. Fouls: 11:23.
Referees: Fuertes – Miranda, Fernández
Attendance: 32 192
Cards: 37. Banega (SEV), 51. Sarabia (SEV), 62. Ben Yedder (SEV), 87. Escudero (SEV) – 22. Čeryšev (VLR), 55. J. Costa (VLR) 62. Ben Yedder (SEV) – 76. J. Costa (VLR)
Penalty missed: 77. Nolito (SEV), keeper Asenjo saved
Ball possession: 58 % : 42 %.
Shots on target: 4:4. Shots off target: 9:0. Corners: 10:2. Offsides: 2:6. Fouls: 11:23.
Sevilla FC:
Soria – Navas, Mercado, Lenglet, Escudero (C) – Banega, N'Zonzi – Sarabia, F. Vázquez (67. Nolito), Sandro Ramírez (85. Roque) – Muriel (54. Ben Yedder).
Subs: S. Rico – Layún, Carriço, Roque, Ben Yedder, Pizarro, Nolito.
Coach:
Villarreal CF: Asenjo – Antonio Rukavina, M. Gaspar (C), V. Ruiz, J. Costa – Trigueros, Hernández – Castillejo, Raba (78. Fuego), Čeryšev (65. R. Soriano) – Bacca (85. Ünal).
Subs: Barbosa – Ünal, N. Sansone, Fuego, R. Soriano, R. Martínez, Francisco Torres.
Coach:
Subs: S. Rico – Layún, Carriço, Roque, Ben Yedder, Pizarro, Nolito.
Coach:
Villarreal CF: Asenjo – Antonio Rukavina, M. Gaspar (C), V. Ruiz, J. Costa – Trigueros, Hernández – Castillejo, Raba (78. Fuego), Čeryšev (65. R. Soriano) – Bacca (85. Ünal).
Subs: Barbosa – Ünal, N. Sansone, Fuego, R. Soriano, R. Martínez, Francisco Torres.
Coach:
Referees: Fuertes – Miranda, Fernández
Attendance: 32 192