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All times are CEST (UTC + 2)
| West Ham – Manchester City | 1:4 (end) | | | Man Utd. – Arsenal | 2:1 (end) |
| Getafe – Girona | 1:1 (end) | | | Alavés – Atlético | 0:1 (end) | | | Valencia – Eibar | 0:0 (end) |
| La Coruňa – Barcelona | 2:4 (end) |
| Mohuč – RB Leipzig | 3:0 (end) | | | Bremen – Dortmund | 1:1 (end) |
| Feyenoord – Sparta Rotterdam | 3:1 (end) | | | Breda – Heerenveen | 3:0 (end) | | | Zwolle – Willem II | 0:1 (end) |
| Ajax – Alkmaar | 3:0 (end) | | | Heracles – Utrecht | 2:2 (end) | | | Arnhem – Twente | 5:0 (end) |
| Venlo – Kerkrade | 1:4 (end) | | | Groningen – Excelsior | 4:0 (end) | | | Den Haag – Eindhoven | 3:3 (end) |
| Beerschot – Antwerp | 0:0 (end) | | | Anderlecht – Charleroi | 3:1 (end) | | | Gent – Standard | 1:3 (end) |
| Rio Ave – Chaves | 2:1 (end) | | | Boavista – FC Ferreira | 1:0 (end) | | | Marítimo – Porto | 0:1 (end) |
| Belenenses – Braga | 0:1 (end) |
| Sturm Graz – Rapid | 4:2 (end) | | | St. Pölten – Salzburg | 0:2 (end) |
| Perm – Spartak | 0:2 (end) | | | FC Zenit – CSKA Moskva | 0:0 (end) | | | Rostov – Tosno | 2:0 (end) |
| Slavia – Slovácko | 0:0 (end) | | | Teplice – Olomouc | 1:2 (end) | | | Zlín – Bohemians 1905 | 1:1 (end) |
| Jablonec – Liberec | 2:0 (end) |
final
Manchester United
2:1
(1:0)
Arsenal FC
Goals:
16. P. Pogba, 90+1. Fellaini (Young) – 51. Mchitarjan (Xhaka)
Ball possession: 59 % : 41 %.
Shots on target: 3:3. Shots off target: 7:4. Corners: 9:0. Offsides: 2:1. Fouls: 12:7.
Referees: Friend – Bennett, Smart
Attendance:
Cards: 24. Xhaka (ARS)
Penalty missed:
Ball possession: 59 % : 41 %.
Shots on target: 3:3. Shots off target: 7:4. Corners: 9:0. Offsides: 2:1. Fouls: 12:7.
Manchester United:
de Gea – A. Valencia, Lindelöf, Smalling, Young – A. Herrera (64. Martial), N. Matić, P. Pogba – Lingard (64. Fellaini), R. Lukaku (50. Rashford), Alexis Sánchez.
Subs: Pereira – Rojo, Mata, Martial, Rashford, McTominay, Fellaini.
Coach:
Arsenal FC: Ospina – Bellerín, Mavropanos, Chambers, Kolašinac (64. Monreal) – Maitland-Niles, Xhaka – Mchitarjan (76. Willock), Nelson (64. Welbeck), Iwobi – Aubameyang.
Subs: Čech – Holding, Monreal, Welbeck, Nketiah, Osei-Tutu, Willock.
Coach:
Subs: Pereira – Rojo, Mata, Martial, Rashford, McTominay, Fellaini.
Coach:
Arsenal FC: Ospina – Bellerín, Mavropanos, Chambers, Kolašinac (64. Monreal) – Maitland-Niles, Xhaka – Mchitarjan (76. Willock), Nelson (64. Welbeck), Iwobi – Aubameyang.
Subs: Čech – Holding, Monreal, Welbeck, Nketiah, Osei-Tutu, Willock.
Coach:
Referees: Friend – Bennett, Smart
Attendance:
Manchester United substitution: Jesse Lingard is replaced by Marouane Fellaini.
Arsenal FC substitution: Sead Kolašinac is replaced by Nacho Monreal.
Arsenal FC substitution: Reiss Nelson is replaced by Danny Welbeck.