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All times are CEST (UTC + 2)
| West Ham – Manchester City | 1:4 (end) | | | Man Utd. – Arsenal | 2:1 (end) |
| Getafe – Girona | 1:1 (end) | | | Alavés – Atlético | 0:1 (end) | | | Valencia – Eibar | 0:0 (end) |
| La Coruňa – Barcelona | 2:4 (end) |
| Mohuč – RB Leipzig | 3:0 (end) | | | Bremen – Dortmund | 1:1 (end) |
| Feyenoord – Sparta Rotterdam | 3:1 (end) | | | Breda – Heerenveen | 3:0 (end) | | | Zwolle – Willem II | 0:1 (end) |
| Ajax – Alkmaar | 3:0 (end) | | | Heracles – Utrecht | 2:2 (end) | | | Arnhem – Twente | 5:0 (end) |
| Venlo – Kerkrade | 1:4 (end) | | | Groningen – Excelsior | 4:0 (end) | | | Den Haag – Eindhoven | 3:3 (end) |
| Beerschot – Antwerp | 0:0 (end) | | | Anderlecht – Charleroi | 3:1 (end) | | | Gent – Standard | 1:3 (end) |
| Rio Ave – Chaves | 2:1 (end) | | | Boavista – FC Ferreira | 1:0 (end) | | | Marítimo – Porto | 0:1 (end) |
| Belenenses – Braga | 0:1 (end) |
| Sturm Graz – Rapid | 4:2 (end) | | | St. Pölten – Salzburg | 0:2 (end) |
| Perm – Spartak | 0:2 (end) | | | FC Zenit – CSKA Moskva | 0:0 (end) | | | Rostov – Tosno | 2:0 (end) |
| Slavia – Slovácko | 0:0 (end) | | | Teplice – Olomouc | 1:2 (end) | | | Zlín – Bohemians 1905 | 1:1 (end) |
| Jablonec – Liberec | 2:0 (end) |
final
West Ham United
1:4
(1:2)
Manchester City
Goals:
42. Cresswell – 13. Sané (Sterling), 27. Zabaleta (own), 53. Jesus (Sterling), 64. Fernandinho (Sterling)
Ball possession: 25 % : 75 %.
Shots on target: 1:7. Shots off target: 2:7. Corners: 0:7. Offsides: 4:1. Fouls: 5:11.
Referees:
Attendance: 56 904
Cards: 37. Otamendi (MAC)
Penalty missed:
Ball possession: 25 % : 75 %.
Shots on target: 1:7. Shots off target: 2:7. Corners: 0:7. Offsides: 4:1. Fouls: 5:11.
West Ham United:
Adrián – Rice, Ogbonna, Cresswell – Zabaleta, Kouyaté, Noble (C), Evra (66. Masuaku) – E. Fernandes (65. Mário), Lanzini (66. J. Hernández) – Arnautović.
Subs: Trott – Masuaku, Mário, Cullen, Carroll, Hugill, J. Hernández.
Coach:
Manchester City: Ederson – Walker (61. Danilo), Otamendi, Laporte, Delph – De Bruyne, Fernandinho (C), Gündoğan (71. Y. Touré) – Sané, Jesus (80. Nmecha), Sterling.
Subs: Bravo – Danilo, Mendy, B. Silva, Y. Touré, Nmecha, Foden.
Coach:
Subs: Trott – Masuaku, Mário, Cullen, Carroll, Hugill, J. Hernández.
Coach:
Manchester City: Ederson – Walker (61. Danilo), Otamendi, Laporte, Delph – De Bruyne, Fernandinho (C), Gündoğan (71. Y. Touré) – Sané, Jesus (80. Nmecha), Sterling.
Subs: Bravo – Danilo, Mendy, B. Silva, Y. Touré, Nmecha, Foden.
Coach:
Referees:
Attendance: 56 904
West Ham United substitution: Manuel Lanzini is replaced by Javier Hernández.