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All times are CEST (UTC + 2)
| Burnley – Watford | 1:3 (end) | | | Manchester City – Huddersfield Town | 6:1 (end) |
| Barcelona – Alavés | 3:0 (end) | | | Eibar – Huesca | 1:2 (end) | | | Rayo Vallecano – Sevilla | 1:4 (end) |
| Real – Getafe | 2:0 (end) |
| Utrecht – Zwolle | 2:0 (end) | | | Emmen – Alkmaar | 1:4 (end) | | | Feyenoord – Excelsior | 3:0 (end) |
| Heerenveen – Arnhem | 1:1 (end) |
| Antwerp – Club Bruggy | 1:1 (end) | | | Genk – Charleroi | 3:1 (end) | | | Eupen – Gent | 2:3 (end) |
| Sporting – Setúbal | 2:1 (end) | | | Nacional – Moreirense | 1:2 (end) | | | Rio Ave – Marítimo | 3:1 (end) |
| Belenenses – Porto | 2:3 (end) | | | Santa Clara – Braga | 3:3 (end) |
| Sturm Graz – Rheindorf Altach | 1:1 (end) | | | Austria – Admira | 4:0 (end) | | | Linz – Rapid | 2:1 (end) |
| Samara – Lok. Moskva | 0:1 (end) | | | FC Zenit – Ural | 4:1 (end) | | | Rostov – Jenisej | 4:0 (end) |
| Karviná – Plzeň | 0:1 (end) | | | Sparta – Příbram | 2:2 (end) |
| Ružomberok – Slovan Bratislava | 0:2 (end) | | | Trenčín – Dunajská Streda | 3:3 (end) |
| Steinbach – Augsburg | 1:2 (end) | | | Hastedt – Mönchengladbach | 1:11 (end) |
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90
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Dave Bulthuis (SC Heerenveen) is shown a yellow card.
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64
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Maikel van der Werff (SBV Vitesse Arnhem) is shown a yellow card.
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44
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Sam Lammers (SC Heerenveen) is shown a yellow card.
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40
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Bryan Linssen (SBV Vitesse Arnhem) is shown a yellow card.
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Goals:
26. Vlap – 81. Matavž
Ball possession: 36 % : 64 %.
Shots on target: 2:4. Shots off target: 3:12. Corners: 1:8. Offsides: 0:0. Fouls: 17:15.
Referees:
Attendance:
Cards: 44. S. Lammers (HEE), 90. Bulthuis (HEE) – 40. Linssen (ARN), 64. van der Werff (ARN)
Penalty missed:
Ball possession: 36 % : 64 %.
Shots on target: 2:4. Shots off target: 3:12. Corners: 1:8. Offsides: 0:0. Fouls: 17:15.
SC Heerenveen:
Hahn – Woudenberg, Höegh, Bulthuis, Pierie – Kobajaši, R. Kongolo, Vlap (80. van Amersfoort) – Zeneli (59. B. Rienstra), S. Lammers, Mihajlović (74. Bruijn).
Subs: Bednarek, Doornbusch – Bruijn, Drkusić, Hornkamp, Naess, Rojas, van Amersfoort, B. Rienstra.
Coach:
SBV Vitesse Arnhem: Eduardo – V. Karavajev, van der Werff (66. Darfalou), Clarke-Salter, Büttner – Serero, Bero (66. Darfalou), Foor – Beerens (88. van Bergen), Matavž, Linssen.
Subs: Pasveer – Bruns, Clark, Darfalou, Karami, Thelander, van Bergen.
Coach:
Subs: Bednarek, Doornbusch – Bruijn, Drkusić, Hornkamp, Naess, Rojas, van Amersfoort, B. Rienstra.
Coach:
SBV Vitesse Arnhem: Eduardo – V. Karavajev, van der Werff (66. Darfalou), Clarke-Salter, Büttner – Serero, Bero (66. Darfalou), Foor – Beerens (88. van Bergen), Matavž, Linssen.
Subs: Pasveer – Bruns, Clark, Darfalou, Karami, Thelander, van Bergen.
Coach:
Referees:
Attendance: