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All times are CEST (UTC + 2)
| Burnley – Watford | 1:3 (end) | | | Manchester City – Huddersfield Town | 6:1 (end) |
| Barcelona – Alavés | 3:0 (end) | | | Eibar – Huesca | 1:2 (end) | | | Rayo Vallecano – Sevilla | 1:4 (end) |
| Real – Getafe | 2:0 (end) |
| Utrecht – Zwolle | 2:0 (end) | | | Emmen – Alkmaar | 1:4 (end) | | | Feyenoord – Excelsior | 3:0 (end) |
| Heerenveen – Arnhem | 1:1 (end) |
| Antwerp – Club Bruggy | 1:1 (end) | | | Genk – Charleroi | 3:1 (end) | | | Eupen – Gent | 2:3 (end) |
| Sporting – Setúbal | 2:1 (end) | | | Nacional – Moreirense | 1:2 (end) | | | Rio Ave – Marítimo | 3:1 (end) |
| Belenenses – Porto | 2:3 (end) | | | Santa Clara – Braga | 3:3 (end) |
| Sturm Graz – Rheindorf Altach | 1:1 (end) | | | Austria – Admira | 4:0 (end) | | | Linz – Rapid | 2:1 (end) |
| Samara – Lok. Moskva | 0:1 (end) | | | FC Zenit – Ural | 4:1 (end) | | | Rostov – Jenisej | 4:0 (end) |
| Karviná – Plzeň | 0:1 (end) | | | Sparta – Příbram | 2:2 (end) |
| Ružomberok – Slovan Bratislava | 0:2 (end) | | | Trenčín – Dunajská Streda | 3:3 (end) |
| Steinbach – Augsburg | 1:2 (end) | | | Hastedt – Mönchengladbach | 1:11 (end) |
postponed
AC Milan
0:0
(-:-)
Genoa CFC
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