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All times are CEST (UTC + 2)
| Tottenham – Arsenal | 1:1 (end) | | | Bournemouth – Manchester City | 0:1 (end) | | | Burnley – Crystal Palace | 1:3 (end) |
| Man Utd. – Southampton | 3:2 (end) | | | West Ham – Newcastle | 2:0 (end) |
| Espanyol – Valladolid | 3:1 (end) | | | Villarreal – Alavés | 1:2 (end) | | | Huesca – Sevilla | 2:1 (end) |
| Real – Barcelona | 0:1 (end) |
| Frankfurt – Hoffenheim | 3:2 (end) | | | Hertha – Mohuč | 2:1 (end) | | | Leverkusen – Freiburg | 2:0 (end) |
| Norimberk – RB Leipzig | 0:1 (end) | | | Schalke – Düsseldorf | 0:4 (end) | | | Mönchengladbach – Bayern | 1:5 (end) |
| Heracles – Utrecht | 1:5 (end) | | | Excelsior – Eindhoven | 0:2 (end) | | | Arnhem – Breda | 4:1 (end) |
| Charleroi – Genk | 1:1 (end) | | | Oostende – Waasland-Beveren | 1:1 (end) | | | Club Bruggy – Sint-Truiden | 1:0 (end) |
| Nacional – Tondela | 3:2 (end) | | | Moreirense – Setúbal | 1:1 (end) | | | Porto – SL Benfica | 1:2 (end) |
| Rheindorf Altach – Admira | 0:1 (end) | | | Salzburg – Wolfsberger | 3:0 (end) | | | St. Pölten – Rapid | 0:4 (end) |
| Ural – FC Zenit | 0:1 (end) | | | Arsenal Tula – CSKA Moskva | 2:0 (end) | | | Lok. Moskva – Samara | 2:2 (end) |
| Kazaň – Grozny | 1:0 (end) |
| Dukla Praha – Olomouc | 0:4 (end) | | | Příbram – Karviná | 2:1 (end) | | | Slovácko – Mladá Boleslav | 1:1 (end) |
| Plzeň – Jablonec | 1:0 (end) | | | Liberec – Sparta | 0:1 (end) |
| Trenčín – Podbrezová | 1:1 (end) | | | Ružomberok – Michalovce | 0:0 (end) | | | Nitra – Sereď | 0:2 (end) |
| Dunajská Streda – Senica | 1:0 (end) | | | Žilina – Zlaté Moravce | 2:1 (end) |
final
Manchester United
3:2
(0:1)
Southampton FC
Goals:
53. Pereira (Dalot), 59. R. Lukaku (Pereira), 88. R. Lukaku – 26. Valery (Ch. Austin), 75. Ward-Prowse
Ball possession: 64 % : 36 %.
Shots on target: 6:3. Shots off target: 10:6. Corners: 9:7. Offsides: 2:0. Fouls: 7:10.
Referees: Attwell – Hatzidakis, West
Attendance: 74459
Cards: 89. R. Lukaku (MAN), 90+6. P. Pogba (MAN) – 39. Bertrand (SOT)
Penalty missed: 90+5. P. Pogba (MAN), keeper Gunn saved
Ball possession: 64 % : 36 %.
Shots on target: 6:3. Shots off target: 10:6. Corners: 9:7. Offsides: 2:0. Fouls: 7:10.
Manchester United:
de Gea – Young (C), Smalling, Lindelöf, Shaw – McTominay, Pereira (82. Fred), P. Pogba – Rashford (90+5. Chong), R. Lukaku, Alexis Sánchez (52. Dalot).
Subs: Grant – Bailly, Rojo, Dalot, Fred, Gomes, Chong.
Coach:
Southampton FC: Gunn – Bednarek, Jošida (90. Gallagher), Vestergaard – Valery, Ward-Prowse, Romeu, P.-E. Höjbjerg (C), Bertrand – Redmond, Ch. Austin (63. Armstrong).
Subs: A. McCarthy – Stephens, Targett, M. Elyounoussi, Armstrong, Slattery, Gallagher.
Coach:
Subs: Grant – Bailly, Rojo, Dalot, Fred, Gomes, Chong.
Coach:
Southampton FC: Gunn – Bednarek, Jošida (90. Gallagher), Vestergaard – Valery, Ward-Prowse, Romeu, P.-E. Höjbjerg (C), Bertrand – Redmond, Ch. Austin (63. Armstrong).
Subs: A. McCarthy – Stephens, Targett, M. Elyounoussi, Armstrong, Slattery, Gallagher.
Coach:
Referees: Attwell – Hatzidakis, West
Attendance: 74459
Scorer is ROMELU LUKAKU.
Scorer is ROMELU LUKAKU. Assisted by Andreas Pereira.
Scorer is ANDREAS PEREIRA. Assisted by Diogo Dalot.