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All times are CEST (UTC + 2)
| Bournemouth – Burnley | 1:3 (end) | | | Huddersfield Town – Leicester | 1:4 (end) | | | Newcastle – Crystal Palace | 0:1 (end) |
| Girona – Espanyol | 1:2 (end) | | | Real – Eibar | 2:1 (end) | | | Rayo Vallecano – Valencia | 2:0 (end) |
| Barcelona – Atlético | 2:0 (end) |
| Hertha – Düsseldorf | 1:2 (end) | | | Leverkusen – RB Leipzig | 2:4 (end) | | | Schalke – Frankfurt | 1:2 (end) |
| Stuttgart – Norimberk | 1:1 (end) | | | Wolfsburg – Hannover | 3:1 (end) | | | Bayern – Dortmund | 5:0 (end) |
| Willem II – Ajax | 1:4 (end) | | | Den Haag – Utrecht | 5:0 (end) | | | Groningen – Excelsior | 1:0 (end) |
| Graafschap – Alkmaar | 1:1 (end) | | | Heracles – Breda | 1:0 (end) |
| Oostende – Beerschot | 2:1 (end) | | | Westerlo – Sint-Truiden | 2:2 (end) | | | St.Gilloise – Waasland-Beveren | 5:1 (end) |
| Genk – Gent | 2:1 (end) |
| Belenenses – Santa Clara | 1:1 (end) | | | Nacional – Aves | 0:0 (end) | | | Guimarães – Chaves | 4:0 (end) |
| Moreirense – Braga | 1:0 (end) |
| Wacker – Rapid | 0:2 (end) | | | Admira – Rheindorf Altach | 1:1 (end) | | | Mattersburg – Hartberg | 3:0 (end) |
| Machačkala – Dynamo | 1:1 (end) | | | FK Krasnodar – Samara | 1:0 (end) | | | Spartak – CSKA Moskva | 0:2 (end) |
| Dukla Praha – Slavia | 1:5 (end) |
| Dunajská Streda – Žilina | 1:0 (end) | | | Sereď – Ružomberok | 0:1 (end) | | | Zlaté Moravce – Podbrezová | 2:1 (end) |
| Trenčín – Senica | 2:3 (end) | | | Trnava – Nitra | 1:1 (end) |
| Sivasspor – Kayserispor | 1:3 (end) | | | Alanyaspor – Bursaspor | 1:0 (end) | | | Galatasaray AŞ – Yeni Malatyaspor | 3:0 (end) |
Goals:
26. Isak (pen.) – 15. van de Beek, 42. Heerkens (own), 53. Veltman, 70. Zijach
Ball possession: 45 % : 55 %.
Shots on target: 4:5. Shots off target: 4:4. Corners: 3:1. Offsides: 0:1. Fouls: 10:15.
Referees:
Attendance:
Cards: 13. Crowley (WLM), 29. Lewis (WLM)
Penalty missed:
Ball possession: 45 % : 55 %.
Shots on target: 4:5. Shots off target: 4:4. Corners: 3:1. Offsides: 0:1. Fouls: 10:15.
Willem II Tilburg:
Wellenreuther – Lewis, Heerkens, Peters (C), Palacios – Anita, Crowley, Llonch – Vrousai (76. Dankerlui), Isak (84. Coulibaly), Pavlidis (90+1. Saddiki).
Subs: Brand, Woud – Akkaynak, Dankerlui, Coulibaly, Meißner, Ogenia, Saddiki, van den Bogert.
Coach:
Ajax Amsterdam: Onana – Veltman, de Ligt (C), Blind, Tagliafico – Schöne (75. de Wit), van de Beek, F. de Jong (84. Sinkgraven) – Zijach, Tadić (75. Huntelaar), Neres.
Subs: Lamprou, B. Varela – de Wit, Dolberg, Huntelaar, Kristensen, Magallán, Lang, Sinkgraven.
Coach:
Subs: Brand, Woud – Akkaynak, Dankerlui, Coulibaly, Meißner, Ogenia, Saddiki, van den Bogert.
Coach:
Ajax Amsterdam: Onana – Veltman, de Ligt (C), Blind, Tagliafico – Schöne (75. de Wit), van de Beek, F. de Jong (84. Sinkgraven) – Zijach, Tadić (75. Huntelaar), Neres.
Subs: Lamprou, B. Varela – de Wit, Dolberg, Huntelaar, Kristensen, Magallán, Lang, Sinkgraven.
Coach:
Referees:
Attendance:
AFC Ajax substitution: Frenkie de Jong is replaced by Daley Sinkgraven.
AFC Ajax substitution: Lasse Schöne is replaced by Dani de Wit.