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All times are CEST (UTC + 2)
| Bournemouth – Burnley | 1:3 (end) | | | Huddersfield Town – Leicester | 1:4 (end) | | | Newcastle – Crystal Palace | 0:1 (end) |
| Girona – Espanyol | 1:2 (end) | | | Real – Eibar | 2:1 (end) | | | Rayo Vallecano – Valencia | 2:0 (end) |
| Barcelona – Atlético | 2:0 (end) |
| Hertha – Düsseldorf | 1:2 (end) | | | Leverkusen – RB Leipzig | 2:4 (end) | | | Schalke – Frankfurt | 1:2 (end) |
| Stuttgart – Norimberk | 1:1 (end) | | | Wolfsburg – Hannover | 3:1 (end) | | | Bayern – Dortmund | 5:0 (end) |
| Willem II – Ajax | 1:4 (end) | | | Den Haag – Utrecht | 5:0 (end) | | | Groningen – Excelsior | 1:0 (end) |
| Graafschap – Alkmaar | 1:1 (end) | | | Heracles – Breda | 1:0 (end) |
| Oostende – Beerschot | 2:1 (end) | | | Westerlo – Sint-Truiden | 2:2 (end) | | | St.Gilloise – Waasland-Beveren | 5:1 (end) |
| Genk – Gent | 2:1 (end) |
| Belenenses – Santa Clara | 1:1 (end) | | | Nacional – Aves | 0:0 (end) | | | Guimarães – Chaves | 4:0 (end) |
| Moreirense – Braga | 1:0 (end) |
| Wacker – Rapid | 0:2 (end) | | | Admira – Rheindorf Altach | 1:1 (end) | | | Mattersburg – Hartberg | 3:0 (end) |
| Machačkala – Dynamo | 1:1 (end) | | | FK Krasnodar – Samara | 1:0 (end) | | | Spartak – CSKA Moskva | 0:2 (end) |
| Dukla Praha – Slavia | 1:5 (end) |
| Dunajská Streda – Žilina | 1:0 (end) | | | Sereď – Ružomberok | 0:1 (end) | | | Zlaté Moravce – Podbrezová | 2:1 (end) |
| Trenčín – Senica | 2:3 (end) | | | Trnava – Nitra | 1:1 (end) |
| Sivasspor – Kayserispor | 1:3 (end) | | | Alanyaspor – Bursaspor | 1:0 (end) | | | Galatasaray AŞ – Yeni Malatyaspor | 3:0 (end) |
Goals:
32. De Tomás (A. Ba), 90+1. Mario Suárez (A. Ba)
Ball possession: 52 % : 48 %.
Shots on target: 5:3. Shots off target: 7:6. Corners: 4:7. Offsides: 1:4. Fouls: 17:10.
Referees: Alberoa – Hernández, Cerdán
Attendance: 11 320
Cards: 15. De Tomás (VLL), 55. Gálvez (VLL) – 29. Torres (VAL), 76. Roncaglia (VAL), 84. Diakhaby (VAL)
Penalty missed: 28. Parejo (VAL), keeper Alberto García saved
Ball possession: 52 % : 48 %.
Shots on target: 5:3. Shots off target: 7:6. Corners: 4:7. Offsides: 1:4. Fouls: 17:10.
Rayo Vallecano:
Alberto García (C) – Advíncula, A. Ba, Gálvez (82. Velázquez), Tito – Pozo, Mario Suárez – Bébé (73. Agbo), Embarba, Á. Moreno (66. Á. García) – De Tomás.
Subs: Dimitrievski – Guerra, Á. García, Agbo, Velázquez, Akieme, Comesaña.
Coach:
Valencia CF: Neto – Roncaglia (81. Wass), Gabriel, Diakhaby, Gayá – Torres (60. Guedes), Parejo (C), Kondogbia, Čeryšev – Rodrigo (60. Gameiro), S. Mina.
Subs: Doménech – Garay, Lato, Wass, Guedes, Soler, Gameiro.
Coach:
Subs: Dimitrievski – Guerra, Á. García, Agbo, Velázquez, Akieme, Comesaña.
Coach:
Valencia CF: Neto – Roncaglia (81. Wass), Gabriel, Diakhaby, Gayá – Torres (60. Guedes), Parejo (C), Kondogbia, Čeryšev – Rodrigo (60. Gameiro), S. Mina.
Subs: Doménech – Garay, Lato, Wass, Guedes, Soler, Gameiro.
Coach:
Referees: Alberoa – Hernández, Cerdán
Attendance: 11 320
Scorer is MARIO SUÁREZ. Assisted by Abdoulaye Ba.
Valencia CF substitution: Rodrigo is replaced by Kévin Gameiro.
Scorer is RAÚL DE TOMÁS. Assisted by Abdoulaye Ba.