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All times are CEST (UTC + 2)
| Levante – Atlético | 2:2 (end) | | | Espanyol – Real Sociedad | 2:0 (end) | | | Getafe – Villarreal | 2:2 (end) |
| Sevilla – Bilbao | 2:0 (end) | | | Valladolid – Valencia | 0:2 (end) | | | Alavés – Girona | 2:1 (end) |
| Celta Vigo – Rayo Vallecano | 2:2 (end) | | | Huesca – Leganés | 2:1 (end) |
| Bayern – Frankfurt | 5:1 (end) | | | Bremen – RB Leipzig | 2:1 (end) | | | Düsseldorf – Hannover | 2:1 (end) |
| Freiburg – Norimberk | 5:1 (end) | | | Hertha – Leverkusen | 1:5 (end) | | | Mohuč – Hoffenheim | 4:2 (end) |
| Mönchengladbach – Dortmund | 0:2 (end) | | | Schalke – Stuttgart | 0:0 (end) | | | Wolfsburg – Augsburg | 8:1 (end) |
| Heracles – Utrecht | 0:2 (end) | | | Groningen – Arnhem | 2:1 (end) |
| Charleroi – Eupen | 2:0 (end) | | | Beerschot – Oostende | 1:2 (end) | | | Sint-Truiden – Westerlo | 2:1 (end) |
| Feirense – Aves | 2:1 (end) | | | Marítimo – Boavista | 0:1 (end) | | | Setúbal – Rio Ave | 1:3 (end) |
| SL Benfica – Santa Clara | 4:1 (end) | | | Porto – Sporting | 2:1 (end) |
| Admira – Wacker | 3:2 (end) | | | Rheindorf Altach – Hartberg | 3:1 (end) | | | Mattersburg – Rapid | 1:0 (end) |
| Ufa – Orenburg | 0:2 (end) | | | CSKA Moskva – Grozny | 1:0 (end) | | | Samara – Spartak | 1:2 (end) |
| Michalovce – Slovan Bratislava | 3:3 (end) | | | Sereď – Žilina | 2:3 (end) | | | Ružomberok – Dunajská Streda | 1:0 (end) |
| Senica – Zlaté Moravce | 3:1 (end) | | | Nitra – Trnava | 0:1 (end) | | | Trenčín – Podbrezová | 4:0 (end) |
| Manchester City – Watford | 6:0 (end) |
| Antalyaspor – Yeni Malatyaspor | 3:0 (end) | | | Trabzonspor – Beşiktaş | 2:1 (end) |
Goals:
44. Ben Yedder, 90+2. Munir (Ben Yedder)
Ball possession: 47 % : 53 %.
Shots on target: 3:1. Shots off target: 5:6. Corners: 2:3. Offsides: 4:0. Fouls: 14:19.
Referees:
Attendance:
Cards: 36. Rog (SEV), 60. Gnagnon (SEV), 60. Navas (SEV) – 19. Dani García (ATB), 29. Raúl García (ATB)
Penalty missed:
Ball possession: 47 % : 53 %.
Shots on target: 3:1. Shots off target: 5:6. Corners: 2:3. Offsides: 4:0. Fouls: 14:19.
Sevilla FC:
Vaclík – Navas, Kjaer, Mercado, Escudero – Rog (46. Gnagnon), Amadou – Aleix Vidal (81. Nolito), F. Vázquez (69. Gil), Munir – Ben Yedder.
Subs: Arana, Gil, Gnagnon, Sergi Gómez, Nolito, Promes.
Coach:
Athletic Bilbao: Herrerín – Capa, Yeray, I. Martínez, Balenziaga (56. I. Gómez) – Beñat, Dani García (76. San José) – Muniain, Raúl García, Berchiche – I. Williams (76. Aduriz).
Subs: Simón – Aduriz, I. Córdoba, de Marcos, I. Gómez, Núñez, San José.
Coach:
Subs: Arana, Gil, Gnagnon, Sergi Gómez, Nolito, Promes.
Coach:
Athletic Bilbao: Herrerín – Capa, Yeray, I. Martínez, Balenziaga (56. I. Gómez) – Beñat, Dani García (76. San José) – Muniain, Raúl García, Berchiche – I. Williams (76. Aduriz).
Subs: Simón – Aduriz, I. Córdoba, de Marcos, I. Gómez, Núñez, San José.
Coach:
Referees:
Attendance:
Athletic Bilbao substitution: Dani García is replaced by Mikel San José.