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All times are CEST (UTC + 2)
| Levante – Atlético | 2:2 (end) | | | Espanyol – Real Sociedad | 2:0 (end) | | | Getafe – Villarreal | 2:2 (end) |
| Sevilla – Bilbao | 2:0 (end) | | | Valladolid – Valencia | 0:2 (end) | | | Alavés – Girona | 2:1 (end) |
| Celta Vigo – Rayo Vallecano | 2:2 (end) | | | Huesca – Leganés | 2:1 (end) |
| Bayern – Frankfurt | 5:1 (end) | | | Bremen – RB Leipzig | 2:1 (end) | | | Düsseldorf – Hannover | 2:1 (end) |
| Freiburg – Norimberk | 5:1 (end) | | | Hertha – Leverkusen | 1:5 (end) | | | Mohuč – Hoffenheim | 4:2 (end) |
| Mönchengladbach – Dortmund | 0:2 (end) | | | Schalke – Stuttgart | 0:0 (end) | | | Wolfsburg – Augsburg | 8:1 (end) |
| Heracles – Utrecht | 0:2 (end) | | | Groningen – Arnhem | 2:1 (end) |
| Charleroi – Eupen | 2:0 (end) | | | Beerschot – Oostende | 1:2 (end) | | | Sint-Truiden – Westerlo | 2:1 (end) |
| Feirense – Aves | 2:1 (end) | | | Marítimo – Boavista | 0:1 (end) | | | Setúbal – Rio Ave | 1:3 (end) |
| SL Benfica – Santa Clara | 4:1 (end) | | | Porto – Sporting | 2:1 (end) |
| Admira – Wacker | 3:2 (end) | | | Rheindorf Altach – Hartberg | 3:1 (end) | | | Mattersburg – Rapid | 1:0 (end) |
| Ufa – Orenburg | 0:2 (end) | | | CSKA Moskva – Grozny | 1:0 (end) | | | Samara – Spartak | 1:2 (end) |
| Michalovce – Slovan Bratislava | 3:3 (end) | | | Sereď – Žilina | 2:3 (end) | | | Ružomberok – Dunajská Streda | 1:0 (end) |
| Senica – Zlaté Moravce | 3:1 (end) | | | Nitra – Trnava | 0:1 (end) | | | Trenčín – Podbrezová | 4:0 (end) |
| Manchester City – Watford | 6:0 (end) |
| Antalyaspor – Yeni Malatyaspor | 3:0 (end) | | | Trabzonspor – Beşiktaş | 2:1 (end) |
Goals:
36. Soler (S. Mina), 53. Rodrigo (Parejo)
Ball possession: 50 % : 50 %.
Shots on target: 4:6. Shots off target: 7:2. Corners: 8:2. Offsides: 1:3. Fouls: 12:10.
Referees:
Attendance:
Cards: 26. B. Fernández (RVL) – 11. Gayá (VAL), 21. Diakhaby (VAL), 41. Guedes (VAL)
Penalty missed:
Ball possession: 50 % : 50 %.
Shots on target: 4:6. Shots off target: 7:2. Corners: 8:2. Offsides: 1:3. Fouls: 12:10.
Real Valladolid:
Y. Rodríguez – Antoñito, Fernández, Olivas, Delgado – B. Fernández (C) (84. F. Calero), Alcaraz (68. Míchel) – Keko (74. Ünal), D. Verde, T. Villa – Čop.
Subs: Masip – F. Calero, Míchel, Moyano, Plano, Rubio, Ünal.
Coach:
Valencia CF: Doménech – Wass, Diakhaby, Gabriel, Gayá – Soler, Parejo (C), Coquelin (59. Kondogbia), Guedes – S. Mina (68. Torres), Rodrigo (64. Gameiro).
Subs: Neto – Gameiro, Kondogbia, Piccini, Roncaglia, Sobrino, Torres.
Coach:
Subs: Masip – F. Calero, Míchel, Moyano, Plano, Rubio, Ünal.
Coach:
Valencia CF: Doménech – Wass, Diakhaby, Gabriel, Gayá – Soler, Parejo (C), Coquelin (59. Kondogbia), Guedes – S. Mina (68. Torres), Rodrigo (64. Gameiro).
Subs: Neto – Gameiro, Kondogbia, Piccini, Roncaglia, Sobrino, Torres.
Coach:
Referees:
Attendance:
Scorer is RODRIGO. Assisted by Dani Parejo.
Scorer is CARLOS SOLER. Assisted by Santiago Mina.