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All times are CEST (UTC + 2)
| Crystal Palace – Tottenham | 3:0 (end) | | | Arsenal – Norwich | 1:0 (end) | | | Leicester – Manchester City | 0:1 (end) |
| Man Utd. – Newcastle | 4:1 (end) | | | Southampton – West Ham | 0:0 (end) | | | Watford – Wolverhampton | 0:2 (end) |
| Chelsea – Aston Villa | 3:0 (end) |
| Levante – Rayo Vallecano | 1:1 (end) | | | Villarreal – Alavés | 0:0 (post.) | | | Bilbao – Mallorca | 2:0 (end) |
| Sevilla – Barcelona | 0:0 (post.) |
| Freiburg – Kolín nad Rýnem | 1:1 (end) | | | Fürth – Wolfsburg | 0:2 (end) | | | Hoffenheim – Mohuč | 0:2 (end) |
| Leverkusen – Dortmund | 3:4 (end) | | | Union Berlín – Augsburg | 0:0 (end) | | | RB Leipzig – Bayern | 1:4 (end) |
| Zlín – Bohemians 1905 | 1:3 (end) | | | Pardubice – Liberec | 2:2 (end) | | | Teplice – Ostrava | 1:2 (end) |
| Plzeň – Sparta | 3:2 (end) |
| Michalovce – Trnava | 1:2 (end) | | | Žilina – Trenčín | 1:3 (end) | | | Sereď – L. Mikuláš | 2:0 (end) |
| Dinamo Zagreb – Šibenik | 2:0 (end) | | | Rijeka – Slaven Belupo | 2:1 (end) |
postponed
Villarreal CF
0:0
(-:-)
Deportivo Alavés
Goals:
Referees:
Attendance:
Penalty missed:
Villarreal CF:
Subs:
Coach:
Deportivo Alavés:
Subs:
Coach:
Subs:
Coach:
Deportivo Alavés:
Subs:
Coach:
Referees:
Attendance:
Scorer is GERARD MORENO. Assisted by Alfonso Pedraza.
Scorer is YEREMI PINO. Assisted by Boulaye Dia.
Scorer is BOULAYE DIA. Assisted by Dani Parejo.
Scorer is BOULAYE DIA. Assisted by Manu Trigueros.
Scorer is GERARD MORENO. Assisted by Dani Parejo.