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All times are CEST (UTC + 2)
| Crystal Palace – Tottenham | 3:0 (end) | | | Arsenal – Norwich | 1:0 (end) | | | Leicester – Manchester City | 0:1 (end) |
| Man Utd. – Newcastle | 4:1 (end) | | | Southampton – West Ham | 0:0 (end) | | | Watford – Wolverhampton | 0:2 (end) |
| Chelsea – Aston Villa | 3:0 (end) |
| Levante – Rayo Vallecano | 1:1 (end) | | | Villarreal – Alavés | 0:0 (post.) | | | Bilbao – Mallorca | 2:0 (end) |
| Sevilla – Barcelona | 0:0 (post.) |
| Freiburg – Kolín nad Rýnem | 1:1 (end) | | | Fürth – Wolfsburg | 0:2 (end) | | | Hoffenheim – Mohuč | 0:2 (end) |
| Leverkusen – Dortmund | 3:4 (end) | | | Union Berlín – Augsburg | 0:0 (end) | | | RB Leipzig – Bayern | 1:4 (end) |
| Zlín – Bohemians 1905 | 1:3 (end) | | | Pardubice – Liberec | 2:2 (end) | | | Teplice – Ostrava | 1:2 (end) |
| Plzeň – Sparta | 3:2 (end) |
| Michalovce – Trnava | 1:2 (end) | | | Žilina – Trenčín | 1:3 (end) | | | Sereď – L. Mikuláš | 2:0 (end) |
| Dinamo Zagreb – Šibenik | 2:0 (end) | | | Rijeka – Slaven Belupo | 2:1 (end) |
postponed
Villarreal CF
0:0
(-:-)
Deportivo Alavés
Goals:
Referees:
Attendance:
Penalty missed:
Villarreal CF:
Subs:
Coach:
Deportivo Alavés:
Subs:
Coach:
Subs:
Coach:
Deportivo Alavés:
Subs:
Coach:
Referees:
Attendance:
Scorer is GERARD MORENO. Assisted by Alfonso Pedraza.
Scorer is YEREMI PINO. Assisted by Boulaye Dia.
Scorer is BOULAYE DIA. Assisted by Dani Parejo.