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All times are CEST (UTC + 2)
| Arsenal – Everton | 0:0 (post.) | | | West Ham – Newcastle | 0:0 (post.) | | | Crystal Palace – Man Utd. | 0:0 (post.) |
| Real – Mallorca | 4:1 (end) | | | Elche – Bilbao | 1:4 (end) | | | Getafe – Real Sociedad | 2:1 (end) |
| Betis – Villarreal | 1:0 (end) |
| Kolín nad Rýnem – Union Berlín | 0:1 (end) | | | Freiburg – Mönchengladbach | 0:0 (end) |
| Ostrava – Pardubice | 3:0 (end) | | | Jablonec – Hr. Králové | 3:0 (end) | | | Mladá Boleslav – Slovácko | 1:1 (end) |
| Bohemians 1905 – Liberec | 0:2 (end) | | | Slavia – Č. Budějovice | 6:1 (end) |
| Trenčín – Trnava | 0:2 (end) |
| Slaven Belupo – Istra 1961 | 0:3 (end) | | | Lokomotiva Zagreb – Varaždin | 1:2 (end) |
postponed
Arsenal FC
0:0
(-:-)
Everton FC
Goals:
Referees:
Attendance:
Penalty missed:
Arsenal FC:
Subs:
Coach:
Everton FC:
Subs:
Coach:
Subs:
Coach:
Everton FC:
Subs:
Coach:
Referees:
Attendance:
Bukayo Saka is replaced by Emile Smith-Rowe.
Olexandr Zinčenko is replaced by Kieran Tierney.
Abdoulaye Doucouré is replaced by Tom Davies.
Granit Xhaka is replaced by Fábio Vieira.
Leandro Trossard is replaced by Eddie Nketiah.
Neal Maupay is replaced by Demarai Gray.
Séamus Coleman is replaced by Ben Godfrey.
Idrissa Gueye is replaced by Mason Holgate.
Jorginho is replaced by Thomas Partey.