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All times are CEST (UTC + 2)
| Arsenal – Everton | 0:0 (post.) | | | West Ham – Newcastle | 0:0 (post.) | | | Crystal Palace – Man Utd. | 0:0 (post.) |
| Real – Mallorca | 4:1 (end) | | | Elche – Bilbao | 1:4 (end) | | | Getafe – Real Sociedad | 2:1 (end) |
| Betis – Villarreal | 1:0 (end) |
| Kolín nad Rýnem – Union Berlín | 0:1 (end) | | | Freiburg – Mönchengladbach | 0:0 (end) |
| Ostrava – Pardubice | 3:0 (end) | | | Jablonec – Hr. Králové | 3:0 (end) | | | Mladá Boleslav – Slovácko | 1:1 (end) |
| Bohemians 1905 – Liberec | 0:2 (end) | | | Slavia – Č. Budějovice | 6:1 (end) |
| Trenčín – Trnava | 0:2 (end) |
| Slaven Belupo – Istra 1961 | 0:3 (end) | | | Lokomotiva Zagreb – Varaždin | 1:2 (end) |
postponed
West Ham United
0:0
(-:-)
Newcastle United
Goals:
Referees:
Attendance:
Penalty missed:
West Ham United:
Subs:
Coach:
Newcastle United:
Subs:
Coach:
Subs:
Coach:
Newcastle United:
Subs:
Coach:
Referees:
Attendance:
Kieran Trippier is replaced by Javier Manquillo.
Daniel Burn is replaced by Matt Targett.
Jacob Murphy is replaced by Joe Willock.
Allan Saint-Maximin is replaced by Anthony Gordon.
Callum Wilson is replaced by Alexander Isak.
Saïd Benrahma is replaced by Maxwel Cornet.
Tomáš Souček is replaced by Flynn Downes.
Michail Antonio is replaced by Danny Ings.
Thilo Kehrer is replaced by Vladimír Coufal.