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| Qarabağ FK – Molde | 1:0 (end) | | | Linz – Liverpool | 1:3 (end) | | | Leverkusen – Häcken | 4:0 (end) |
| Panathinaikos – Villarreal | 2:0 (end) | | | Rennes – Maccabi Haifa | 3:0 (end) | | | St.Gilloise – Toulouse | 1:1 (end) |
| Servette FC – Slavia | 0:2 (end) | | | FC Sheriff – Roma | 1:2 (end) | | | Ajax – Marseille | 3:3 (end) |
| Atalanta BC – Raków | 2:0 (end) | | | Brighton – AEK Atény | 2:3 (end) | | | Olympiacos – Freiburg | 2:3 (end) |
| Rangers – Betis | 1:0 (end) | | | Sparta – Aris Limassol | 3:2 (end) | | | Sturm Graz – Sporting | 1:2 (end) |
| West Ham – Bačka Topola | 3:1 (end) |
| Fenerbahçe – Nordsjaelland | 3:1 (end) | | | Ferencváros – Čukarički | 3:1 (end) | | | Frankfurt – Aberdeen | 2:1 (end) |
| Genk – Fiorentina | 2:2 (end) | | | Helsinki – PAOK | 2:3 (end) | | | Legia – Aston Villa | 3:2 (end) |
| Ludogorec – Trnava | 4:0 (end) | | | Zrinjski Mostar – Alkmaar | 4:3 (end) | | | Club Bruggy – Beşiktaş | 1:1 (end) |
| Dinamo Zagreb – Astana | 5:1 (end) | | | Lugano – Bodø/Glimt | 0:0 (end) | | | Maccabi Tel Aviv – Breiðablik | 3:2 (end) |
| Slovan Bratislava – KÍ Klaksvík | 2:1 (end) | | | Plzeň – FC Ballkani | 1:0 (end) | | | Zorja Luhansk – Gent | 1:1 (end) |
final
Olympiacos FC 
2:3
(1:2)
SC Freiburg |
88
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Yellow card for team Olympiacos FC (Daniel Podence).
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69
|
Yellow card for team SC Freiburg (Roland Sallai).
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|
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52
|
Yellow card for team SC Freiburg (Kenneth Schmidt).
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35
|
Yellow card for team Olympiacos FC (Ayoub El Kaabi).
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26
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Yellow card for team SC Freiburg (Lucas Höler).
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22
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Yellow card for team Olympiacos FC (Diego Martinez).
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Goals:
40. El Kaabi (Rodinei), 75. El Kaabi (Fortunis) – 9. Sallai, 45+7. Grifo (pen.), 86. Philipp
Ball possession: 52 % : 48 %.
Shots on target: 4:6. Shots off target: 13:6. Corners: 8:5. Offsides: 2:0. Fouls: 13:12.
Referees: Lindhout – Honig, Inia
Attendance: 30056
Cards: 22. Diego Martinez (OLY), 35. El Kaabi (OLY), 88. Podence (OLY) – 26. Höler (FRE), 52. K. Schmidt (FRE), 69. Sallai (FRE)
Penalty missed:
Ball possession: 52 % : 48 %.
Shots on target: 4:6. Shots off target: 13:6. Corners: 8:5. Offsides: 2:0. Fouls: 13:12.
Olympiacos FC:
Paschalakis – Rodinei, Retsos, Freire, Ortega (78. Quini) – Hezze (25. Iborra), Camara – Masouras (61. Jovetić), Biel (46. Podence), Fortunis (C) (79. Solbakken) – El Kaabi.
Subs: Tzolakis – El Arabi, Alexandropoulos, Ntoi, Porozo, Scarpa, Vrousai.
Coach: Diego Martinez
SC Freiburg: Atubolu – Kübler, Günter, Lienhart, K. Schmidt (54. Sildillia) – Eggestein, Höfler – Doan (90+2. Adamu), Sallai (76. Philipp), Grifo (C) (76. Weißhaupt) – Höler (90+2. Keitel).
Subs: Müller – Breunig, Makengo, Röhl.
Coach: Christian Streich
Subs: Tzolakis – El Arabi, Alexandropoulos, Ntoi, Porozo, Scarpa, Vrousai.
Coach: Diego Martinez
SC Freiburg: Atubolu – Kübler, Günter, Lienhart, K. Schmidt (54. Sildillia) – Eggestein, Höfler – Doan (90+2. Adamu), Sallai (76. Philipp), Grifo (C) (76. Weißhaupt) – Höler (90+2. Keitel).
Subs: Müller – Breunig, Makengo, Röhl.
Coach: Christian Streich
Referees: Lindhout – Honig, Inia
Attendance: 30056