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| Roma – FC Sheriff | 3:0 (end) | | | Qarabağ FK – Häcken | 2:1 (end) | | | Linec – Toulouse | 1:2 (end) |
| Leverkusen – Molde | 5:1 (end) | | | Pan. Ateny – Maccabi Haifa | 1:2 (end) | | | Rennes – Villarreal | 2:3 (end) |
| St.Gilloise – Liverpool | 2:1 (end) | | | Slavia – Servette FC | 4:0 (end) | | | Ajax – AEK Atény | 3:1 (end) |
| Aris Limassol – Sparta | 1:3 (end) | | | Betis – Rangers | 2:3 (end) | | | Brighton – Marseille | 1:0 (end) |
| Olympiacos – Bačka Topola | 5:2 (end) | | | Raków – Atalanta BC | 0:4 (end) | | | Sporting – Sturm Graz | 3:0 (end) |
| West Ham – Freiburg | 2:0 (end) |
| Aberdeen – Frankfurt | 2:0 (end) | | | Fenerbahçe – Trnava | 4:0 (end) | | | Ferencváros – Fiorentina | 1:1 (end) |
| Genk – Čukarički | 2:0 (end) | | | Legia – Alkmaar | 2:0 (end) | | | Ludogorec – Nordsjaelland | 1:0 (end) |
| PAOK – Helsinki | 4:2 (end) | | | Zrinjski Mostar – Aston Villa | 1:1 (end) | | | Club Bruggy – Bodø/Glimt | 3:1 (end) |
| Dinamo Zagreb – FC Ballkani | 3:0 (end) | | | Lille – KÍ Klaksvík | 3:0 (end) | | | Lugano – Beşiktaş | 0:2 (end) |
| Maccabi Tel Aviv – Gent | 3:1 (end) | | | Slovan Bratislava – Ljubljana | 1:2 (end) | | | Plzeň – Astana | 3:0 (end) |
| Zorja Luhansk – Breiðablik | 4:0 (end) |
final
Stade Rennes 
2:3
(1:1)
Villarreal CF |
90+1
|
Yellow card for team Villarreal CF (Dani Parejo).
|
|
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45+1
|
Yellow card for team Stade Rennes FC (Steve Mandanda).
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|
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36
|
Yellow card for team Villarreal CF (Gerard Moreno).
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|
33
|
Yellow card for team Stade Rennes FC (Jeanuel Belocian).
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23
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Yellow card for team Stade Rennes FC (Benjamin Bourigeaud).
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19
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Yellow card for team Villarreal CF (Raúl Albiol).
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9
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Yellow card for team Stade Rennes FC (Christopher Wooh).
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Goals:
37. Assignon (Le Fée), 79. Blas (Matić) – 36. G. Moreno (pen.), 62. Akhomach (G. Moreno), 80. Parejo (Baena)
Ball possession: 55 % : 45 %.
Shots on target: 5:5. Shots off target: 2:3. Corners: 4:3. Offsides: 3:4. Fouls: 11:15.
Referees: Karaoglan – Sesigüzel, Komurcuoglu.
Attendance: 27761
Cards: 9. Wooh (REN), 23. Bourigeaud (REN), 33. Belocian (REN), 45+1. Mandanda (REN) – 19. Albiol (VLR), 36. G. Moreno (VLR), 90+1. Parejo (VLR)
Penalty missed:
Ball possession: 55 % : 45 %.
Shots on target: 5:5. Shots off target: 2:3. Corners: 4:3. Offsides: 3:4. Fouls: 11:15.
Stade Rennes:
Mandanda (C) – Assignon, Wooh, Belocian (69. Truffert), Theate – Bourigeaud (54. Blas), Le Fée, Matić, Nagida (69. I. Saláh) – Yıldırım (69. Gújrí), Terrier (84. Kalimuendo).
Subs: Gallon, Lembet – D. Doué, G. Doué, Omari, Rieder, Santamaría.
Coach: Julien Stéphan.
Villarreal CF: Reina – Foyth (48. Terrats), Albiol (C), Gabbia, Altimira – Akhomach (72. Coquelin), Capoue (85. Cuenca), Parejo, Baena – G. Moreno (85. Brereton Díaz), Sörloth (72. Morales).
Subs: Jörgensen, I. Álvarez – Femenía, A. Moreno, Trigueros.
Coach: Marcelino García Toral.
Subs: Gallon, Lembet – D. Doué, G. Doué, Omari, Rieder, Santamaría.
Coach: Julien Stéphan.
Villarreal CF: Reina – Foyth (48. Terrats), Albiol (C), Gabbia, Altimira – Akhomach (72. Coquelin), Capoue (85. Cuenca), Parejo, Baena – G. Moreno (85. Brereton Díaz), Sörloth (72. Morales).
Subs: Jörgensen, I. Álvarez – Femenía, A. Moreno, Trigueros.
Coach: Marcelino García Toral.
Referees: Karaoglan – Sesigüzel, Komurcuoglu.
Attendance: 27761