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| Tottenham – Bournemouth | 4:0 (end) | | | Crystal Palace – Leicester | 2:2 (end) | | | Everton – Burnley | 3:1 (end) |
| Stoke – Hull City | 3:1 (end) | | | Sunderland – West Ham | 2:2 (end) | | | Watford – Swansea | 1:0 (end) |
| Southampton – Manchester City | 0:3 (end) |
| La Coruňa – Malaga | 2:0 (end) | | | Gijón – Real | 2:3 (end) | | | Atlético – Osasuna | 3:0 (end) |
| Barcelona – Real Sociedad | 3:2 (end) |
| Dortmund – Frankfurt | 3:1 (end) | | | Mohuč – Hertha | 1:0 (end) | | | Wolfsburg – Ingolstadt | 3:0 (end) |
| Augsburg – Kolín nad Rýnem | 2:1 (end) | | | Hoffenheim – Mönchengladbach | 5:3 (end) | | | RB Leipzig – Freiburg | 4:0 (end) |
| Leverkusen – Bayern | 0:0 (end) |
| Kerkrade – Sparta Rotterdam | 3:1 (end) | | | Den Haag – Eindhoven | 1:1 (end) | | | Excelsior – Arnhem | 1:0 (end) |
| Twente – Nijmegen | 3:0 (end) |
| Waasland-Beveren – Mechelen | 1:2 (end) | | | Eupen – Lokeren | 3:3 (end) | | | Roeselare – Mouscron | 3:5 (end) |
| Sint-Truiden – Lierse | 2:1 (end) |
| Arouca – Feirense | 2:0 (end) | | | Chaves – Guimarães | 2:3 (end) | | | Tondela – Rio Ave | 2:1 (end) |
| Braga – Porto | 1:1 (end) |
| Wolfsberger – Salzburg | 0:2 (end) | | | Rapid – Rheindorf Altach | 3:0 (end) | | | Admira – St. Pölten | 2:0 (end) |
| Sturm Graz – Ried | 1:0 (end) |
| Perm – Ufa | 1:1 (end) | | | CSKA Moskva – Rostov | 0:0 (end) | | | Machačkala – Samara | 1:3 (end) |
| Kazaň – FK Krasnodar | 0:1 (end) |
| Brno – Jablonec | 2:0 (end) | | | Příbram – Karviná | 4:2 (end) | | | Zlín – Teplice | 0:2 (end) |
| Mladá Boleslav – Bohemians 1905 | 1:1 (end) | | | Jihlava – Sparta | 1:0 (end) |
| Trenčín – Dunajská Streda | 0:1 (end) | | | Podbrezová – Michalovce | 1:4 (end) | | | Zlaté Moravce – Senica | 2:1 (end) |
final
Atlético Madrid
3:0
(1:0)
CA Osasuna
Goals:
30. Ferreira-Carrasco (Luís), 47. Ferreira-Carrasco (Gaitán), 61. Luís (Á. Correa)
Referees: Melero – Torre, J. Martínez
Attendance:
Cards: 25. J. Giménez (ATM) – 43. Kodro (OSS), 54. Oier (OSS), 90. De las Cuevas (OSS), 90. Fuentes (OSS)
Penalty missed: 89. Ferreira-Carrasco (ATM), keeper Sirigu saved, 90. Partey (ATM), keeper Sirigu saved
Atlético Madrid:
Oblak – Torres Juanfran, Godín, Hernández, Luís (67. Savić) – Ferreira-Carrasco, J. Giménez, Partey, Gaitán (76. Cerci) – F. Torres (72. Tiago), Á. Correa.
Subs: Moreira – Tiago, Griezmann, Saúl, Cerci, Savić, Bare.
Coach:
CA Osasuna: Sirigu – Berenguer, D. García, Oier, Fuentes, C. Clerc (57. Buñuel) – Olavide (57. De las Cuevas), Čaušić, Fausto (77. R. Torres) – León, Kodro.
Subs: N. Pérez – O. Riera, R. Torres, De las Cuevas, Vujadinović, Mérida, Buñuel.
Coach:
Subs: Moreira – Tiago, Griezmann, Saúl, Cerci, Savić, Bare.
Coach:
CA Osasuna: Sirigu – Berenguer, D. García, Oier, Fuentes, C. Clerc (57. Buñuel) – Olavide (57. De las Cuevas), Čaušić, Fausto (77. R. Torres) – León, Kodro.
Subs: N. Pérez – O. Riera, R. Torres, De las Cuevas, Vujadinović, Mérida, Buñuel.
Coach:
Referees: Melero – Torre, J. Martínez
Attendance:
Scorer is FILIPE LUÍS. Assisted by Ángel Correa.