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All times are CEST (UTC + 2)
| Tottenham – Bournemouth | 4:0 (end) | | | Crystal Palace – Leicester | 2:2 (end) | | | Everton – Burnley | 3:1 (end) |
| Stoke – Hull City | 3:1 (end) | | | Sunderland – West Ham | 2:2 (end) | | | Watford – Swansea | 1:0 (end) |
| Southampton – Manchester City | 0:3 (end) |
| La Coruňa – Malaga | 2:0 (end) | | | Gijón – Real | 2:3 (end) | | | Atlético – Osasuna | 3:0 (end) |
| Barcelona – Real Sociedad | 3:2 (end) |
| Dortmund – Frankfurt | 3:1 (end) | | | Mohuč – Hertha | 1:0 (end) | | | Wolfsburg – Ingolstadt | 3:0 (end) |
| Augsburg – Kolín nad Rýnem | 2:1 (end) | | | Hoffenheim – Mönchengladbach | 5:3 (end) | | | RB Leipzig – Freiburg | 4:0 (end) |
| Leverkusen – Bayern | 0:0 (end) |
| Kerkrade – Sparta Rotterdam | 3:1 (end) | | | Den Haag – Eindhoven | 1:1 (end) | | | Excelsior – Arnhem | 1:0 (end) |
| Twente – Nijmegen | 3:0 (end) |
| Waasland-Beveren – Mechelen | 1:2 (end) | | | Eupen – Lokeren | 3:3 (end) | | | Roeselare – Mouscron | 3:5 (end) |
| Sint-Truiden – Lierse | 2:1 (end) |
| Arouca – Feirense | 2:0 (end) | | | Chaves – Guimarães | 2:3 (end) | | | Tondela – Rio Ave | 2:1 (end) |
| Braga – Porto | 1:1 (end) |
| Wolfsberger – Salzburg | 0:2 (end) | | | Rapid – Rheindorf Altach | 3:0 (end) | | | Admira – St. Pölten | 2:0 (end) |
| Sturm Graz – Ried | 1:0 (end) |
| Perm – Ufa | 1:1 (end) | | | CSKA Moskva – Rostov | 0:0 (end) | | | Machačkala – Samara | 1:3 (end) |
| Kazaň – FK Krasnodar | 0:1 (end) |
| Brno – Jablonec | 2:0 (end) | | | Příbram – Karviná | 4:2 (end) | | | Zlín – Teplice | 0:2 (end) |
| Mladá Boleslav – Bohemians 1905 | 1:1 (end) | | | Jihlava – Sparta | 1:0 (end) |
| Trenčín – Dunajská Streda | 0:1 (end) | | | Podbrezová – Michalovce | 1:4 (end) | | | Zlaté Moravce – Senica | 2:1 (end) |
Goals:
47. Joselu (Luisinho), 67. Mosquera (Gil)
Referees:
Attendance:
Cards: 21. Guilherme (DEP), 72. A. Arribas (DEP), 90+2. Gil (DEP) – 22. Recio (MLG), 23. L. Hernández (MLG), 73. Keko (MLG), 73. Charles (MLG)
Penalty missed:
Deportivo La Coruňa:
Lux – Juanfran, A. Arribas, Sidnei (C), Luisinho – Guilherme, C. Borges – G. Kakuta (83. John), Gil, Gama (63. Mosquera) – Joselu (59. Andone).
Subs: Tytoń – Andone, Albentosa, Colak, John, Mosquera, Laure.
Coach:
Malaga CF: Kameni – Rosales, D. Llorente, L. Hernández (60. Keko), Villanueva – Recio (70. Charles), Camacho (C) – G. Castro (60. Jony), Fornals, J. P. Carlos – Sandro Ramírez.
Subs: Bojko – Duda, Charles, Demichelis, Santos, Jony, Keko.
Coach:
Subs: Tytoń – Andone, Albentosa, Colak, John, Mosquera, Laure.
Coach:
Malaga CF: Kameni – Rosales, D. Llorente, L. Hernández (60. Keko), Villanueva – Recio (70. Charles), Camacho (C) – G. Castro (60. Jony), Fornals, J. P. Carlos – Sandro Ramírez.
Subs: Bojko – Duda, Charles, Demichelis, Santos, Jony, Keko.
Coach:
Referees:
Attendance:
Scorer is PEDRO MOSQUERA. Assisted by Carles Gil.
Scorer is JOSELU. Assisted by Luisinho.