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All times are CEST (UTC + 2)
| Tottenham – Manchester City | 4:1 (end) | | | Leicester – Arsenal | 2:5 (end) | | | Liverpool – Aston Villa | 3:2 (end) |
| Stoke – Bournemouth | 2:1 (end) | | | West Ham – Norwich | 2:2 (end) | | | Man Utd. – Sunderland | 3:0 (end) |
| Southampton – Swansea | 3:1 (end) | | | Newcastle – Chelsea | 2:2 (end) |
| Barcelona – Las Palmas | 2:1 (end) | | | Real – Malaga | 0:0 (end) | | | Sevilla – Rayo Vallecano | 3:2 (end) |
| Villarreal – Atlético | 1:0 (end) | | | Eibar – Celta Vigo | 1:1 (end) |
| Wolfsburg – Hannover | 1:1 (end) | | | Stuttgart – Mönchengladbach | 1:3 (end) | | | Augsburg – Hoffenheim | 1:3 (end) |
| Bremen – Leverkusen | 0:3 (end) | | | Mohuč – Bayern | 0:3 (end) | | | Hamburg – Schalke | 0:1 (end) |
| Heerenveen – Arnhem | 0:0 (end) | | | Utrecht – Cambuur | 3:3 (end) | | | Ajax – Groningen | 2:0 (end) |
| Alkmaar – Heracles | 3:1 (end) | | | Eindhoven – Nijmegen | 2:1 (end) |
| Waasland-Beveren – Gent | 1:3 (end) | | | Mechelen – Charleroi | 0:1 (end) | | | Mouscron – Oostende | 2:2 (end) |
| Standard – Leuven | 2:2 (end) |
| SL Benfica – FC Ferreira | 3:0 (end) | | | Boavista – Sporting | 0:0 (end) |
| Ried – Rapid | 0:1 (end) | | | Salzburg – Mattersburg | 4:2 (end) | | | Rheindorf Altach – Grödig | 1:0 (end) |
| Austria – Wolfsberger | 1:0 (end) |
| CSKA Moskva – Lok. Moskva | 1:1 (end) | | | Machačkala – Ufa | 1:1 (end) | | | Spartak – FC Zenit | 2:2 (end) |
| Olomouc – Zlín | 1:1 (end) | | | Dukla Praha – Brno | 1:2 (end) | | | Příbram – Jihlava | 4:1 (end) |
| Slovácko – Bohemians 1905 | 1:0 (end) | | | Teplice – Ostrava | 1:0 (end) | | | Plzeň – Liberec | 2:1 (end) |
| Senica – Myjava | 0:1 (end) | | | Trenčín – Skalica | 3:0 (end) | | | Ružomberok – Dunajská Streda | 1:0 (end) |
Goals:
23. Gameiro (Trémoulinas), 45+1. N'Zonzi (J. A. Reyes), 86. Konopljanka – 52. Bébé, 68. Guerra
Ball possession: 49 % : 51 %.
Shots on target: 7:5. Shots off target: 4:9. Corners: 6:5. Offsides: 2:0. Fouls: 9:15.
Referees: Hernández – Sobrino, Naranjo
Attendance:
Cards: 17. Iborra (SEV) – 15. D. Llorente (VLL), 17. Amaya (VLL), 87. Trashorras (VLL) 83. Amaya (VLL)
Penalty missed:
Ball possession: 49 % : 51 %.
Shots on target: 7:5. Shots off target: 4:9. Corners: 6:5. Offsides: 2:0. Fouls: 9:15.
Sevilla FC:
S. Rico – Coke (75. Mariano), Andreolli, Kolodziejczak, Trémoulinas – Krychowiak, N'Zonzi (74. Cristóforo), Iborra (63. Konopljanka) – J. A. Reyes, Gameiro, Krohn-Dehli.
Subs: Soria – Immobile, Cristóforo, Luismi, Konopljanka, F. Llorente, Mariano.
Coach:
Rayo Vallecano: Toño – N. Martínez, Amaya, D. Llorente, Raţ – Baena, Trashorras (85. Dorado) – Bébé, Jo. Sánchez, Embarba (65. Bangoura) – Guerra (80. Manucho).
Subs: Carlos – Dorado, Fedor, Manucho, Fariña, Quini, Bangoura.
Coach:
Subs: Soria – Immobile, Cristóforo, Luismi, Konopljanka, F. Llorente, Mariano.
Coach:
Rayo Vallecano: Toño – N. Martínez, Amaya, D. Llorente, Raţ – Baena, Trashorras (85. Dorado) – Bébé, Jo. Sánchez, Embarba (65. Bangoura) – Guerra (80. Manucho).
Subs: Carlos – Dorado, Fedor, Manucho, Fariña, Quini, Bangoura.
Coach:
Referees: Hernández – Sobrino, Naranjo
Attendance:
Antonio Amaya (Rayo Vallecano) is shown a yellow card.