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| Man Utd. – Manchester City | 1:2 (end) | | | Bournemouth – West Brom | 1:0 (end) | | | Arsenal – Southampton | 2:1 (end) |
| Burnley – Hull City | 1:1 (end) | | | Middlesbrough – Crystal Palace | 1:2 (end) | | | Stoke – Tottenham | 0:4 (end) |
| West Ham – Watford | 2:4 (end) | | | Liverpool – Leicester | 4:1 (end) |
| Celta Vigo – Atlético | 0:4 (end) | | | Real – Osasuna | 5:2 (end) | | | Malaga – Villarreal | 0:2 (end) |
| Sevilla – Las Palmas | 2:1 (end) | | | Barcelona – Alavés | 1:2 (end) |
| Leverkusen – Hamburg | 3:1 (end) | | | Wolfsburg – Kolín nad Rýnem | 0:0 (end) | | | Ingolstadt – Hertha | 0:2 (end) |
| Darmstadt – Frankfurt | 1:0 (end) | | | Freiburg – Mönchengladbach | 3:1 (end) | | | RB Leipzig – Dortmund | 1:0 (end) |
| Alkmaar – Willem II | 2:0 (end) | | | Zwolle – Utrecht | 1:1 (end) | | | Nijmegen – Eindhoven | 0:4 (end) |
| Heerenveen – Twente | 3:1 (end) | | | Excelsior – Heracles | 3:1 (end) |
| Eupen – Oostende | 2:1 (end) | | | Kortrijk – Westerlo | 4:1 (end) | | | Mechelen – Sint-Truiden | 2:0 (end) |
| Mouscron – Waregem | 1:5 (end) |
| Belenenses – Nacional | 2:1 (end) | | | Sporting – Moreirense | 3:0 (end) | | | Porto – Guimarães | 3:0 (end) |
| Sturm Graz – Rapid | 1:1 (end) | | | Austria – Wolfsberger | 4:1 (end) | | | Rheindorf Altach – Mattersburg | 2:1 (end) |
| St. Pölten – Ried | 2:3 (end) |
| Perm – Tomsk | 1:0 (end) | | | Orenburg – Machačkala | 0:0 (end) | | | CSKA Moskva – Grozny | 3:0 (end) |
| Sparta – Mladá Boleslav | 2:2 (end) | | | Hradec Králové – Příbram | 2:0 (end) | | | Karviná – Jihlava | 3:0 (end) |
| Liberec – Plzeň | 1:2 (end) |
| Trenčín – Trnava | 3:3 (end) | | | Slovan Bratislava – Myjava | 1:2 (end) | | | Michalovce – Žilina | 0:2 (end) |
| Senica – Ružomberok | 1:1 (end) |
Goals:
1. Karami, 19. Koolwijk, 22. Fredy – 66. Vermeij
Referees: Manschot – Balder, Kleinjan
Attendance:
Cards: 53. Bruins (EXC), 71. Hadouir (EXC), 80. Ondaan (EXC) – 37. Bruns (HRC)
Penalty missed:
SBV Excelsior:
Muyters – Karami, H. Drost, Mattheij, Kuipers – Koolwijk, Vermeulen (83. Faik), Bruins – Fredy, Hasselbaink (67. Hadouir), Elbers (69. Ondaan).
Subs: Kurto, Havekotte – Owusu, Hadouir, Ondaan, Arghus, Massop, Faik, Pantić.
Coach:
Heracles Almelo: B. Castro – Droste (72. Armenteros), te Wierik, Hoogma, Gosens – Bruns, Pelupessy, Vujičević (46. Fledderus) – Navrátil (46. Kuwas), Vermeij, Darri.
Subs: Fij, Brouwer – Breukers, R. Pröpper, Armenteros, L. Duarte, Kada, Kuwas, van Ooijen, van Mieghem, Fledderus.
Coach:
Subs: Kurto, Havekotte – Owusu, Hadouir, Ondaan, Arghus, Massop, Faik, Pantić.
Coach:
Heracles Almelo: B. Castro – Droste (72. Armenteros), te Wierik, Hoogma, Gosens – Bruns, Pelupessy, Vujičević (46. Fledderus) – Navrátil (46. Kuwas), Vermeij, Darri.
Subs: Fij, Brouwer – Breukers, R. Pröpper, Armenteros, L. Duarte, Kada, Kuwas, van Ooijen, van Mieghem, Fledderus.
Coach:
Referees: Manschot – Balder, Kleinjan
Attendance:
Heracles Almelo substitution: Dario Vujičević is replaced by Mark-Jan Fledderus.